Cell Penetrating Peptide Function
Rational design and application of a new cell-penetrating peptide targeting mitochondria
... altered function of many metabolic enzymes in the mitochondrial matrix as well as in the electron transport ...loses function upon oxidation is SOD, which would further compromise antioxidant capacity and ...
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PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy
... lung function; highlighting the need to develop formulations with improved gene transfer potency and the desirable physiochemical characteristics for e ffi cacious ...novel cell penetrating ...
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A cell penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment
... a cell-penetrating ARF 26–44 peptide inhibitor of FoxM1 ...tumor cell proliferation and angiogenesis and a significant increase in apoptosis within the HCC region but not in the adjacent ...
14
The Telomerase-Derived Anticancer Peptide Vaccine GV1001 as an Extracellular Heat Shock Protein-Mediated Cell-Penetrating Peptide
... TAT peptide, GV1001 enables the cytosolic delivery of such macromolecules as proteins, DNA and siRNA via eHSP90 or eHSP70 ...CPP function may explain its increased anticancer immune response relative to ...
7
Enhancing cellular uptake of activable cell-penetrating peptide–doxorubicin conjugate by enzymatic cleavage
... Activable cell-penetrating peptides (ACPPs) containing polycationic CPPs, enzyme-sensitive substrate, and poly- anionic inhibitory domains have been developed by Tsien’s group as molecular imaging probes in ...
9
Evaluating the efficacy of HTL001, a cell penetrating peptide that targets the HOX/PBX interaction in ovarian cancer.
... biological function of the peptide (Figure ...Cleaving Peptide from Equine Rhinitis A virus) [141, ...the peptide in human reticulocytes, precursors of lineage blood cells without ...
232
<p>Enhanced Efficacy of Photodynamic Therapy by Coupling a Cell-Penetrating Peptide with Methylene Blue</p>
... Several studies have reported photodynamic cell death mediated by MB as measured by flow cytometry and fluorescence microscopy. Some studies have shown that, in cells incubated with MB, MB entered the cyto- ...
9
Targeted gene silencing in human embryonic stem cells using cell-penetrating peptide PepFect 14
... siB2M triggered modest and short-term reduction of mRNA and protein levels of B2M confirming that RNAi was indeed achieved through mRNA degradation, rather than by interfering with translation, which is the mech- anism ...
14
Intracellular delivery of cell-penetrating peptide-transcriptional factor fusion protein and its role in selective osteogenesis
... At day 3, it increased ALP and Runx2 expression, resulting in further stimulation of the late markers OCN and OPN. The primary biological function of ALP in bone formation is associated with calcification of the ...
14
Antitumor activity of tripterine via cell-penetrating peptide-coated nanostructured lipid carriers in a prostate cancer model
... Our results for spleen and thymus index determination indicate that tripterine could inhibit immune function via its immunosuppressive action. Nevertheless, CT-NLC and T-NLC had less significant immunosuppressive ...
12
<p>Cell penetrating peptide-modified nanoparticles for tumor targeted imaging and synergistic effect of sonodynamic/HIFU therapy</p>
... immunomodulatory function and etc. 26,27 F3 peptide is known for mediating dual-target- ing delivery to speci fi c tumor cells and tumor angiogenesis by selectively binding to nucleolin, which is expressed ...
20
Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptide-modified liposomal system
... not cell or tissue specific, and their transloca- tion across the cell membrane occurs in nearly all cell types by means of heparan sulfates and other ...activatable cell-penetrating ...
21
Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer
... CPP, cell-penetrating peptide; ELP, elastin-like ...the peptide to a mac- romolecular carrier, such as ELP. The p21 peptide, origi- nally described in Mutoh et al, used here is derived ...
10
Photodynamic therapy by conjugation of cell-penetrating peptide with fluorochrome
... as cell-penetrating peptides, have membrane-translocating and nuclear-localizing activities, which have led to their application in various drug delivery ...arginine-rich peptide with membrane- ...
12
Synthesis and study of cell-penetrating peptide-modified gold nanoparticles
... nanoparticles, cell-penetrating peptide, cysteine, fibroblast Introduction In nanomedicine, gold nanoparticles (AuNPs) have provided many solutions for the treatment of a variety of diseases, ...
7
Conjugation of an oligonucleotide to Tat, a cell penetrating peptide, via click chemistry
... have produced oligonucleotide peptide conjugates (OPCs) using click chemistry, 18 we.. 30..[r] ...
6
Synthesis and Antiproliferative Activities of Conjugates of Paclitaxel and Camptothecin with a Cyclic Cell-Penetrating Peptide
... Cyclic Peptide [W(RW) 4 K(βAla)] (P1) The linear peptide with protected side chains was prepared using Fmoc/tBu ...The peptide sequence was assembled on the H-Trp(Boc)-2-chlorotrityl resin (513 mg, ...
15
Investigation of Cell-Penetrating Peptide Transformation in Two Regenerable Tissue Culture Systems
... the cell on its own before it can carry along a cargo ...of penetrating both cell types ...developed cell wall, which may constrain the movement of the CPP into the ...
91
A branched TAT cell-penetrating peptide as a novel delivery carrier for the efficient gene transfection
... Background: Cell penetrating peptides (CPPs) as one class of non-viral vectors, have been widely explored as a delivery tool due to their cell-penetrating capability with low ...TAT ...
8
The effect of dexamethasone/cell-penetrating peptide nanoparticles on gene delivery for inner ear therapy
... Dex. BDNF has been reported to be involved in both the development and maintenance of spiral ganglion neurons. 21 Furthermore, BDNF is also expressed in hair cells, as well as in the supporting cells of the organ of ...
12