cell receptor signaling
HIV-1 Nef: a multifaceted modulator of T cell receptor signaling
... T-cell receptor signaling and IL-2 production by virtue of an ITAM motif not present in any other Nef protein ...TCR signaling by HIV-1 ...immortalized cell lines rather than primary ...
11
Viral Modulation of T-Cell Receptor Signaling
... TcR signaling in EBV-infected T cells is disrupted via the action of the latent membrane protein 2A ...TcR signaling; the relative contributions of decreased overall TcR expression versus se- questration of ...
11
B cell activator PAX5 promotes lymphomagenesis through stimulation of B cell receptor signaling
... lymphoma cell lines, Myc5- M5 and Myc5-M12, which spontaneously silence ...Pax5–tamoxifen receptor fusion protein (Pax5ERTAM) increased neoplastic growth in a hormone-dependent ...B cell ...
10
Targeting early B-cell receptor signaling induces apoptosis in leukemic mantle cell lymphoma
... BCR-induced cell survival (Figure ...BCR signaling in mediating survival signals in MCL cells and point out to the effi- ciency of dasatinib in suppressing cell survival signal em- anating from the ...
14
Racial differences in B cell receptor signaling pathway activation
... B cell subset frequencies and BCR-mediated signaling pathway activation were found amongst AA and EA ...B cell subpopulation frequencies and BCR signaling in additional ethnic ...immune ...
7
T cell receptor signaling for γδT cell development
... γδΤ17 cell phenotype at the expense of the γδΤ1 cell phenotype ...γδT1 cell development also requires costimulation via CD27, a TNF receptor superfamily protein expressed in γδT1 cells, but ...
11
Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics
... B cell receptor signaling pathway, G-protein coupled purinergic nucle- otide receptor signaling pathway, regulation of immune response, ...nucleotide receptor activity, ...
11
Drug Modulators of B Cell Signaling Pathways and Epstein-Barr Virus Lytic Activation
... These results parallel values reported in the literature for inhibition of BTK, PI3K ␦ , and LYN enzymatic activities (8–10). As shown in Fig. 2B, these agents block anti-Ig-induced phosphorylation of downstream B ...
13
Correlations of gene expression with ratings of inattention and hyperactivity/impulsivity in tourette syndrome: a pilot study
... B cell development, antigen presentation pathway, cardiac β-adrenergic signaling, B cell receptor signaling, primary immunodeficiency sig- naling and GM-CSF signaling (Table 1, ...
8
Oncogenic Protein Kinase D3 Regulating Networks in Invasive Breast Cancer
... tumor cell transformation of colon cancer and modulate cancer related STAT-β-catenin pathway ...T cell antigen receptor (TCR) is essential for thymocyte development and effector T cell ...
11
Emerging role of Toll-like receptor 4 in hepatocellular carcinoma
... tumor cell survival by activating the TLR4 expressed on tumor cells and subsequently upregulating nuclear factor-kappa B (NF- κ B) signaling and antiapoptotic ...
7
Ion channel TRPV1 dependent activation of PTP1B suppresses EGFR associated intestinal tumorigenesis
... factor receptor (EGFR), a known mediator of proliferation, and the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), in intestinal epithelial cells ...epithelial cell ...
15
The Role of STAT3 in the Pathogenesis of Chronic Lymphocytic Leukaemia
... chemokine receptor signalling pathways and integrin activation, which function in cell migration and adhesion (de Gorter et ...CLL cell proliferation and survival (Krysov et ...nuclear ...
250
GLP 1 receptor agonists show neuroprotective effects in animal models of diabetes
... GLP-1 receptor activation not only normalizes insulin signaling, but the impaired signaling of several other key growth factors, such as insulin-like growth factor 1 (IGF-1) (Moloney et ...GLP-1 ...
20
Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development
... III receptor (Blobe et ...kinase receptor TrkA (Lou et ...1 receptor (IGF1R) (Booth et ...lutropin receptor (Hirakawa et ...myeloid cell-surface marker CD93 (Bohlson et ...cultured ...
10
In silico identification of potential key regulatory factors in smoking-induced lung cancer
... Toll-like receptor, ErbB, and insulin signaling; purine and ether lipid metabolism; adherens junctions; regulation of autophagy; snare interactions in vesicular transport; and cell cycle) have been ...
11
Identification of LCK as a key mediator of B cell receptor (BCR)signalling in chronic lymphocytic leukaemia (CLL)
... Evidence that BCR is engaged on CLL cells whilst in vivo is suggested in studies showing increased expression of BCR target genes and low expression of surface IgM in freshly isolated CLL cells 80 105-106 . Moreover, a ...
197
Epidermal Growth Factor Receptor PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells
... other cell lines, including Vero, MRC-5, and HeLa, to determine whether EGFR activation was required for HSV-1 ...3 Receptor tyrosine kinases and PI3K are involved in cofilin ...the cell lysates were ...
15
The CD4 Receptor: An Indispensable Protein in T Cell Activation and A Promising Target for Immunosuppression
... CD4 receptor enhances T cell sensitivity The adhesion and signaling function of the CD4 receptor stress its importance in T cell ...T cell responsiveness and that it may be ...
18
Original Article Folate receptor alpha promotes endometrial carcinoma cell proliferation and inhibits apoptosis by regulating the ERK signaling pathway
... folate receptor alpha (FRα) ...coupled receptor can phosphorylate ERK in ...ERK signaling pathway through the non-receptor tyrosine kinase ...ERK signaling pathway in the pathogenesis ...
8