cellular response to DNA damage
Phosphatases in the cellular response to DNA damage
... the cellular response to DNA damage. The DNA damage response network is composed of a large number of proteins with different functions that detect and signal the presence ...
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<p>Digital Immune-Related Gene Expression Signatures In High-Grade Serous Ovarian Carcinoma: Developing Prediction Models For Platinum Response</p>
... is DNA damage, different DNA-damage repair systems stand in the focus of research for the prediction of platinum response, 5,30 including nucleotide excision repair, mis- match repair, ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... similar response and share many of the same proteins as DNA damage-induced breaks, repair mechanisms like non-homologous end joining (NHEJ) are able to join any two dysfunctional chromosomal ends and ...
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Serotype-Specific Inactivation of the Cellular DNA Damage Response during Adenovirus Infection
... of DNA ligase IV by Ad5 requires the activity of Cul5 ...Similarly, DNA ligase IV degradation appears not to involve cullin 2 or ...and DNA ligase IV degradation will have to await further ...
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Structure of the Herpes Simplex Virus 1 Genome: Manipulation of Nicks and Gaps Can Abrogate Infectivity and Alter the Cellular DNA Damage Response
... HSV-1 DNA stimulates replication protein A (RPA) phos- phorylation in transfected cells but not infected ...virion DNA is linear, it has ends that may be recognized as double- strand breaks by ...HSV ...
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Scorpins in the DNA Damage Response
... intricate cellular networks responsible for DNA repair, cell cycle arrest, disposal of potentially damaged organelles or protein aggregates upon DDR activation and cell ...
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Bocavirus Infection Induces a DNA Damage Response That Facilitates Viral DNA Replication and Mediates Cell Death
... a response by either nonspecific nicking of the cellular DNA by Rep78 (9) or NS1-induced reactive oxygen species (ROS) as a DNA damage agent ...of DNA replication achieved by ...
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SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells
... regulate cellular NHEJ repair and acquisition of genetic mutations in cancer cells in response to DNA damage or therapeutic stress, a phenotype consistent with their opposing interaction with ...
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LKB1 is a DNA damage response protein that regulates cellular sensitivity to PARP inhibitors
... in DNA repair is increased radiation sensitivity, and hence extensive apoptotic cell death following ...physiological response against DNA damage and repair of SSB-induced DNA ...
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The Papillomavirus E1 Helicase Activates a Cellular DNA Damage Response in Viral Replication Foci
... double-stranded DNA viruses that infect cutaneous and mucosal epithelial cells of ...double-stranded DNA, which typically contains seven to eight ...viral DNA replication (reviewed in reference ...
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DNA repair deficiency and senescence in concussed professional athletes involved in contact sports
... in response to injury or infection ...of cellular senescence in endothelial ...senescence. Cellular sen- escence is therefore a powerful mechanism affecting mainly glial cells and capable of inducing ...
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p16 and ARF: activation of teenage proteins in old age
... in response to several cellular stresses (15), it is still considered to be one of the best markers of senescence available ...of DNA-damage foci is a more specific marker for senescence. ...
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The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF kappaB activation
... upon cellular stimulation allowing active NF- κ B to enter the nucleus and stimulate the transcription of specific genes ...the DNA damage response (DDR) is also known to result in the ...
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Role and Regulation of CIEBPa in Response to DNA Damage
... C/EBPα contains several putative phosphorylation sites suggesting regulation of C/EBPα by post-translational modifications. In AML patients, activated Fms-like tyrosine kinase 3 (Flt3) inhibits C/EBPα function by ...
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The Smc complexes in DNA damage response
... the cellular DNA damage ...in DNA repair and their cell cycle regulation by posttranslational modifications, such as acetylation, phosphorylation, and ...promote DNA repair and genomic ...
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Roles of Ubiquitination and SUMOylation in DNA Damage Response
... Notably, each ubiquitin contains seven lysine residues. Addition of a ubiquitin to a prior ubiqui- tin molecule can be linked through each of seven lysine residues in ubiquitin, or through a head-to- toe ligation, ...
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Moser, Christina (2017): Novel treatment strategies and mechanisms of actin binding compounds in cancer therapy. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Natural compounds, which influence the cellular cytoskeleton, have been used very successfully for decades in cancer treatment. Microtubule manipulating substances such as paclitaxel, epothilone or colchicine, are ...
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A Synthetic Circuit For Control Of The Bacterial Dna Damage Response Without Dna Damage
... error-prone DNA repair in response to DNA ...a DNA damaging event, the damage sensor RecA activates LexA to undergo a self-cleavage reaction that results in LexA dissociation from SOS ...
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checkpoint following DNA damage by doxorubicin during transient mitotic arrest
... from DNA damage is critical for cell survival. The serious damage is not able to be repaired during checkpoint and finally induces cell death to prevent abnormal cell ...serious DNA ...
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14 Electromagnetic Waves.pdf
... At the molecular level, exposure of ionisation radiation on human tissues may damage proteins and DNA. At the sub-cellular level, ionising radiation can damage chromosomes which are [r] ...
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