cellular senescence
miR-125b induces cellular senescence in malignant melanoma
... We have previously shown by miRNA array approach that miR-125b is expressed in primary cutaneous MM [26,41]. By comparing metastasizing and non-metastasizing stage T2 cutaneous MM we detected an overall decrease in ...
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Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence
... To further confirm accelerated ageing due to the re- duced expression of spindle checkpoint genes, we ana- lyzed several molecular markers including p21 and p16 that are frequently linked to cellular ...
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p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia
... Here we examined the relative influence of p19ARF or p53 loss on the ability of MYC inactivation to elicit sustained tumor regression in a conditional transgenic mouse model of T-ALL. The loss of p19ARF or p53 completely ...
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Jumonji C Demethylases in Cellular Senescence
... during cellular senescence, and this may in part help maintain the CDKN2A locus (encoding p14 ARF and p16 INK4A ) in a demethylated and activated state (39, ...
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Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control
... of cellular senescence, the state of irreversible G1 cell cycle arrest provoked by diverse oncogenic ...cells, senescence cell cycle arrest can be reversed by subsequent inactivation of pRb, ...
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Spy1 Regulation of the DNA Damage Response; Checkpoint Activation and Cellular Senescence
... Cellular senescence is a programmed response triggered in normal cells experiencing various types of stimuli, including telomere erosion [1-3], DNA damage [4], induction of oncogenes [5] and oxidative ...
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Is cellular senescence involved in cystic fibrosis?
... supporting senescence biogenesis ...sociated cellular senescence might be involved in CF and that the correction of CFTR function can also ameliorate senescence ...mitochondrial-induced ...
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Induction of Cellular Senescence As A Novel Therapeutic Strategy for Melanoma Treatment
... Oncogene-induced senescence (OIS) is a well-documented phenomenon both in vitro and in vivo as a tumor- suppression ...repress cellular senescence to facilitate its ...oncogene-induced ...
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Potential role of cellular senescence on coronavirus infections
... role cellular senescence plays in the disparity observed in COVID-19 ...to cellular senescence, and individuals with any of these conditions are at increased risk of COVID-19 ...to ...
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Dissecting cellular senescence and SASP in Drosophila
... Cellular senescence has been considered to be a major defense mechanism against carcinogenesis through the induction of stable cell cycle arrest [1 – ...oncogene-induced senescence (OIS) can block ...
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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
... targeting cellular senescence and the SASP Potential strategies for mitigating the deleterious effects of senes- cent cells include interfering with pathways that lead to senes- cence-associated growth ...
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Cellular senescence in cancer treatment: friend or foe?
... trophe, cellular senescence, or simply necrosis — raises the question of whether additional stimuli or specific contextual scenarios determine the ultimate cell ...premature senescence as a quan- ...
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Interplay of Id and INK4 proteins in cellular senescence
... In vivo overexpression studies have shown that the Cip/Kip proteins prevent normal fibroblasts from entering S phase (Harper et al., 1993; Lee et al., 1995b; Matsuoka et al., 1995; Polyak et al., 1994a), suggesting a ...
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The ING tumor suppressors in cellular senescence and chromatin
... A common structural feature of ING factors is the conserved plant homeodomain (PHD), which can bind directly to the histone mark trimethylated lysine of histone H3 (H3K4me3). PHD mutants lose the ability to undergo ...
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HMGA2 expression in white adipose tissue linking cellular senescence with diabetes
... ample evidence that a gain of fat cells depends on the activation of HMGA2. First, the constitutive activation of HMGA2, e.g., by chromosomal rearrangements causes lipomas, i.e., benign adipocytic tumors (Ashar et al. ...
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Cellular senescence in tissue repair: every cloud has a silver lining
... that cellular senescence has positive roles in wound healing and tissue repair suggest the possibility that it could also play a role in natural ...of cellular senescence contributes to ...of ...
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Mechanisms and functions of cellular senescence
... Cellular senescence was initially considered to be a cell-intrinsic ...termed senescence-associated secretory phenotype (SASP) or senescence-messaging secretome (58, ...
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Strategies targeting cellular senescence
... Upcoming challenges of strategies to target cellular senescence. The main question that still remains in the field is the efficiency of dif- ferent senotherapies in different tissues of human patients. Many ...
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Progesterone and FOXO1 signaling : harnessing cellular senescence for the treatment of ovarian cancer
... lished ovarian cancer cell lines of different histological subtypes to show that progestins activate nuclear PR, leading to elevated FOXO1 expression and ultimately cellular senescence. senescence is ...
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The immunoregulatory effects of CMV-infection in human fibroblasts and the impact on cellular senescence
... the cellular microenvir- ...imitating senescence-related inflammation CMV induces a robust inflammatory response in fibroblasts, which may contribute to age-related inflammation later in ...with ...
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