Cellular Senescence and Apoptosis
Effect of kidney ischemia/reperfusion injury on proliferation, apoptosis, and cellular senescence in acute kidney injury in mice
... of apoptosis which also occurs in the interstitial area in the extension ...on cellular senescence The expression of p16 mRNA in the I/R group also had differences compared with the control ...
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Dissecting cellular senescence and SASP in Drosophila
... or apoptosis? Apart from cellular senescence, apoptosis also acts as a major defense mechanism against tumorigenesis ...[139]. Apoptosis is an active cell death program executed by ...
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Strategies targeting cellular senescence
... certain senescence epitopes might be also expressed to some extent in nonsenescent cells, such as stressed cells or secretory ...of senescence. The senescence program contributes to embryogenesis, ...
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Inhibitory effect of phytol on cellular senescence
... induces apoptosis, was reduced in a concentration-dependent manner, confirming that phytol protected cells from ...-induced senescence in a concentration- dependent manner, and the cellular ...
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Is cellular senescence involved in cystic fibrosis?
... In fact, primary bronchial epithelial cells obtained from 9 patients with CF showed increased levels of p16 and DNA damage response markers, such as phospho-histone 2AX and phospho-checkpoint kinase 2 [23]. In the same ...
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Cellular Senescence in Idiopathic Pulmonary Fibrosis
... Conceptually, CS is a mechanism to counteract malignant transformation; over time, cells inevitably accumulate irrepa- rable damage and, in response, may either undergo apoptosis or senescence to prevent ...
A pro longevity role for cellular senescence
... Cellular senescence is a fundamental process that may play positive or detrimental roles for the ...undergo senescence when challenged with DNA damage than cells derived from short-lived ...response, ...
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Jumonji C Demethylases in Cellular Senescence
... 56. Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IWF, Houtsmuller AB, Pothof J, de Bruin ...
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New strategies for the treatment of cellular senescence
... of cellular senescence in accelerating aging phenotypes and support the hypothesis that healthspan and tissue dysfunction can be delayed by removal of senescent ...of cellular senescence could ...
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Cellular senescence: immunosurveillance and future immunotherapy
... During apoptosis, oxidatively modified lipids on the surface of cell membranes can function as pattern recognition ligands promoting macrophage recognition and phagocytosis via the scavenger receptor CD36 (Hazen, ...
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Small Molecular Weight Modulators of Apoptosis and Senescence
... In the second part of the study, we investigated the ability WS-CoQ 10 to lower the unusually high levels of endogenous oxidative stress generated by PS-1 mutated AD fibroblasts and its effect on cellular ...
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The ING tumor suppressors in cellular senescence and chromatin
... many cellular pathways linked to cancer and cell proliferation such as cell cycle regulation, cellular senescence, DNA repair, apoptosis, inhibition of angiogenesis and modulation of ...
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Cellular senescence in cancer treatment: friend or foe?
... premature senescence as a quan- titative response to anticancer agents in vivo (1, ...premature senescence when apopto- sis was blocked by overexpression of the strictly anti- apoptotic mediator Bcl2 ...
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Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond
... Figure 2. Mechanisms underlying an aging skeleton and potential therapeutic options. Bone formation which entails recruitment of BMSCs to the bone surface, differentiation into osteoblasts and mineraliza- tion by the ...
The emerging role of cellular senescence in renal diseases
... benefit of removing senescent cells has not been completely clari- fied by these experiments. Feasibility of this treatment for each kid- ney disease should also be evaluated. Kidney transplantation may be a suitable ...
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Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
... and cellular senescence in mammalian cells (reviewed in Balaban et ...The senescence of mouse em- bryonic fibroblasts (MEFs), which have long telomeres, is likely to occur via accumulation of ROS ...
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miR-125b induces cellular senescence in malignant melanoma
... Abstract Background: Micro RNAs (miRs) have emerged as key regulators during oncogenesis. They have been found to regulate cell proliferation, differentiation, and apoptosis. Mir-125b has been identified as an ...
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Expression of Senescence and Apoptosis Biomarkers in Synchronous
... ously in the same patient [1,2]. Despite its relatively improbable occurrence, SBBC pro‐ vides an avenue to study treatment outcomes and associated cellular and molecular pro‐ cesses in a uniform pharmacokinetic ...
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CELLULAR replicative senescence or cell senescence
... numerous cellular processes and extracellular matrix ...in cellular senescence, but whether ILK is the cause of senescence or an accompanying phenomenon still remains to be ...of ...
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Mechanisms and functions of cellular senescence
... the senescence program, such as the SASP, to enter into a second step of “full ...of senescence progression may help account for the heterogeneity of senescent cells and their associated phenotypes in ...
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