Central Carbon Metabolism
Deep refactoring of central carbon metabolism in the soil bacterium Pseudomonas putida
... sole carbon source, indicating that the genetic manipulations in strain GC1 do not significantly affect bacterial growth through ...the central carbon ...
171
Development of an accurate kinetic model for the central carbon metabolism of Escherichia coli
... tral metabolism have been ...of central metabolic ...the central carbon metabolism, including glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway, the ...
19
Recent advances in engineering the central carbon metabolism of industrially important bacteria
... the central carbon metabolism and of the flux distribution at metabolic branch points, provide detailed information not only for single reactions but also for whole pathways of a variety of ...the ...
13
The potential for non-adaptive origins of evolutionary innovations in central carbon metabolism
... a metabolism viable on a carbon source if its biomass synthesis rate is more than 1 % of the biomass synthesis rate of the network formed by all N=51 reactions in central carbon ...
16
Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism
... Nutan Gupta 1*† , Shweta Duggal 1† , Ajay Kumar 1 , Najmuddin Mohd Saquib 1 and Kanury V. S. Rao 1,2 Abstract Objective: Signal transduction not only initiates entry into the cell cycle, but also reprograms the cell’s ...
6
Intracellular Staphylococcus aureus Modulates Host Central Carbon Metabolism To Activate Autophagy
... ABSTRACT Staphylococcus aureus is a facultative intracellular pathogen that invades and replicates within many types of phagocytic and nonphagocytic cells. During in- tracellular infection, S. aureus is capable of ...
16
Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism
... with central carbon metabolism, and in the brain, glucose is the primary energy ...Glucose metabolism has been shown to be altered in different neurodegenerative ...and metabolism is ...
84
Palbociclib and fulvestrant act in synergy to modulate central carbon metabolism in breast cancer cells
... in central carbon metabolism: The tricarboxylic acid (TCA) cycle, PPP, and purine ...succinate metabolism possibly through inhibition of succinate dehydrogenase ...in central ...
15
Diversity of flux distribution in central carbon metabolism of S. cerevisiae strains from diverse environments
... Then, we considered the biological variance between strains to identify the more robust and variable fluxes of the central carbon metabolism by studying the indi- vidual flux distributions (Fig. 1) ...
13
Exercise inhibits tumor growth and central carbon metabolism in patient-derived xenograft models of colorectal cancer
... and metabolism in each of these models in the presence and absence of exercise was markedly differ- ent, lending further appreciation to our understanding of the metabolic diversity in ...moral central ...
11
The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum
... IMPORTANCE The malaria parasite has a voracious appetite, requiring large amounts of glucose and nutrients for its rapid growth and proliferation inside hu- man red blood cells. The host cell is resource rich, but this ...
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THESIS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY. Metabolic Engineering of Central Carbon Metabolism in Saccharomyces cerevisiae MARTA PAPINI
... and carbon dioxide at high flux, its amenability to genetic modification and the presence of extensive knowledge ...The central carbon metabolism of ...cellular metabolism and its ...
84
Genetic response to metabolic fluctuations: correlation between central carbon metabolism and DNA replication in Escherichia coli
... Although it was observed previously that regulation of DNA replication may depend on bacterial cell metabo- lism, it was generally assumed that this dependency is indirect. For example, it might result from different ...
11
The Transcription Factor StuA Regulates Central Carbon Metabolism, Mycotoxin Production, and Effector Gene Expression in the Wheat Pathogen Stagonospora nodorum
... sole carbon source restored the growth rate defect observed on glucose, although sporulation remained ...regulating central carbon metabolism, with glycolysis, the TCA cycle, and amino acid ...
9
Regulation of PTS systems and their interplay with central carbon metabolism in Pseudomonas putida
... as carbon source is due to inherent fructose contamination on glucose preparations From β-galactosidase activity measurements a higher activity of the fructose operon promoter on glucose (23 ± 8 U Miller) was ...
183
Regulatory Tasks of the Phosphoenolpyruvate Phosphotransferase System of Pseudomonas putida in Central Carbon Metabolism
... regulating central carbon catabolism has been investigated by measuring the metabolic fluxes of isogenic strains bearing nonpolar mutations in PTS Fru or PTS Ntr genes and grown on either fructose (a PTS ...
9
Central Carbon Metabolism and Electron Transport in Chlamydomonas reinhardtii: Metabolic Constraints for Carbon Partitioning between Oil and Starch
... glucose metabolism and hydrogen photopro- duction by the sole insertion of a hexose uptake protein (hexose uptake protein 1 [HUP1]) in the plasma membrane of Chlamy- domonas (46) suggests that cytosolic glucose ...
18
Structure-guided Inhibitor Design of Mycobacterium Tuberculosis Drug Targets from Central Carbon Metabolism
... 18 Another major problem of using rifamycins in TB treatment is its susceptibility to drug-drug interactions due to its ability to induce drug transporter proteins, P- glycoproteins and drug-metabolising enzymes, ...
210
Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli
... as carbon source, this sugar is imported by the phosphoenolpyruvate (PEP):sugar phosphotransfer- ase system (PTS) that couples the transfer of the phos- phate group from PEP to this sugar, thus generating as ...
13
CceR and AkgR Regulate Central Carbon and Energy Metabolism in Alphaproteobacteria
... in central carbon metabolism, the vast majority of CceR sites were found upstream of genes pre- dicted to be involved in the transport or metabolism of plant- derived carbon sources, ...
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