Ceramide synthase
Targeting ceramide synthase 6–dependent metastasis prone phenotype in lung cancer cells
... while ceramide synthase 2 (CERS2) and CERS6 expres- sion levels were found to be increased in cancerous breast tissues as compared with those in normal breast tissues ...on ceramide, as CERS6 ...
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Differential Regulation of Ceramide Synthase Components LAC1 and LAG1 in Saccharomyces cerevisiae
... Along with membrane transporters such as Pdr5p, the IPT1 gene encoding the enzyme inositol phosphotransferase has been found by recent experiments to be transcriptionally reg- ulated by Pdr1p and Pdr3p (23). IPT1 ...
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Ceramide synthase 5 mediates lipid induced autophagy and hypertrophy in cardiomyocytes
... specific ceramide N-acyl chain length in this process and demon- strated a requirement for (dihydro)ceramide synthase 5 in cardiomyocyte autophagy and myristate-mediated ...
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By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Stichoposide D inhibits growth of leukemia xenografts
... Stichoposide D (STD) is a marine triterpene glycoside isolated from sea cucumbers. We examined the molecular mechanisms underlying the antitumor activity of STD in human leukemia cells. The role of Fas (CD95), ...
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Ceramide/Long-Chain Base Phosphate Rheostat in Saccharomyces cerevisiae: Regulation of Ceramide Synthesis by Elo3p and Cka2p
... ␣⬘ catalytic subunit of the CK2 kinase, thus indicating that CK2 kinase is a novel determinant of a fully functional ceramide synthase. Deletion of DPL1 was previously demonstrated to be lethal in strains ...
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Rheumatoid arthritis reprograms circadian output pathways
... S7. Ceramide synthesis pathway gene expression ...18). Ceramide synthase gene expression was determined by ...(F) Ceramide synthetic pathway gene expression in liver and limb from CIA and ...
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TAP independent self peptides enhance T cell recognition of immune escaped tumors
... We previously isolated a CD8+ T cell clone LnB5 that specifically recognizes a TEIPP antigen from TRH4, a housekeeping ceramide synthase, presented by the MHC-I molecule Db on TAP-defici[r] ...
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Role of ceramide in diabetes mellitus: evidence and mechanisms
... of ceramide in mesangial cell ...When ceramide generation was inhibited using SPT inhibitors and ceramide synthase inhibitors, a reduction in tubular epithelial cell death was observed ...
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Daunorubicin activates NFkappaB and induces kappaB dependent gene expression in HL 60 promyelocytic and Jurkat T lymphoma cells
... by ceramide via enhanced ceramide synthase ...of ceramide has been directly linked with the activation of the transcription factor, NF k B, this was investigated as a novel target for the ...
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The therapeutic potential of modulating the ceramide/sphingomyelin pathway
... novo ceramide biosynthesis requires coordinate action of serine palmitoyl transferase and ceramide synthase to generate ...by ceramide synthase to generate ...to ceramide by ...
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Involvement of Ceramide in the Propagation of Japanese Encephalitis Virus
... membranes. Ceramide is one of the intermediates of sphingo- lipids and plays roles in cell differentiation, regulation of apop- tosis and protein secretion, induction of cellular senescence, and other processes ...
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Ceramide Suppresses Influenza A Virus Replication In Vitro
... (19). Ceramide is a central intermediate in sphingolipid ...(21–27). Ceramide is produced through three distinct metabolic pathways: de novo biosynthesis, sphingomyelin (SM) hydrolysis, and salvage ...by ...
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Obesity associated steatotic liver exhibits aberrant or altered sphingolipid composition and preferentially accumulates ceramide species containing long chain fatty acids
... LC-MS analysis of SPH revealed that there is a trend towards up-regulation of SPH in obese tissue, although the results for lean and obese rats do not differ signifi- cantly. Though SPH is a bioactive lipid that is ...
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Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase
... glucosylceramide synthase have been proposed in connection with this so-called substrate deprivation approach, including 1-phenyldecanoylamino-3-morpholino-1-propanol and its analogue ...
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Role of Ceramide Kinase in Breast Cancer Progression
... by ceramide synthase is also subject to tight regulation involving a complex balance between the six isoforms ...regulation, ceramide synthase activity was recently found to be modulated by ...
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Investigations of carbocyclisation reactions in prodiginine alkaloid biosynthesis
... Analysis of cluster 15 identified by antiSMASH, which shows 53% similarity to the gene cluster that directs the biosynthesis of ECO-02301, suggested it directs the production of a novel metabolite (Figure 4.8). ECO-02301 ...
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Plasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women
... methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) are genes that en- code enzymes involved in the folate and Hcy metabolic pathway, which are ...
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Squalene synthase cloning and functional identification in wintersweet plant (Chimonanthus zhejiangensis)
... Isolation of squalene synthase genes from wintersweet The full-length sequences of squalene synthase from C. salicifolius, C. zhejiangensis, C. grammalus were first identified by transcriptomic sequencing ...
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Sphingolipid and ceramide homeostasis : potential therapeutic targets
... IPC synthase and inositol-based sphingolipids in mammalian cells, highlights the therapeutic potential of inhibitors tar- geting fungal IPC ...IPC synthase is a valid target for antiprotozoal compounds ...
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Anti Plasmodium activity of ceramide analogs
... these ceramide analogs do not inhibit parasite growth through modifica- tions of infected-erythrocyte membrane ...permeabilities. Ceramide is at the parting of different ways of sphingoli- pid ...ferent ...
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