cerebellar purkinje response cell
Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death
... tive response to misfolded protein stress in the nervous system, other data indicate that dysfunctional autophagy can contribute to neurodegeneration and neuron cell death ...of cell death (type II ...
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Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse
... granule cell prolifera- tion is delayed in Car8 wdl mice and that a large precursor pool is likely present at P5 and available to reconstitute the ...of cerebellar morphogenesis in the Car8 wdl model. ...
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Purkinje cell injury, structural plasticity and fusion in patients with Friedreich’s ataxia
... controlling Purkinje cell fusion in response to injury; however, inflammatory cues are known to play a physiologically significant ...between Purkinje cells and BMDCs occurs ordinarily at low ...
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A new Purkinje cell antibody (anti-Ca) associated with subacute cerebellar ataxia: immunological characterization
... normal cell count and persistent intrathecal IgG ...closed cerebellar atrophy at month 4 (Figure ...right cerebellar hemisphere. The exaggerated startle response was stabilized by lorazepam ...
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Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression
... In several other cell signaling studies such an ‘activity increase window’ has been proposed to explain surpris- ing results [53,54]. For instance, neutrophils derived from rheumatoid arthritis patients show ...
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‘Medusa head ataxia’: the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII
... group I mGluRs, IP3 receptors, ryanodine receptors and Shank proteins. Homer-3 is thought to cross-link the cyto- plasmic C-terminus of mGluR1 (especially the mGluR1a isoform [42, 43]) to ITPR1, both of which contain a ...
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Modification of Synaptic-Input Clustering by Intrinsic Excitability Plasticity on Cerebellar Purkinje Cell Dendrites
... the cerebellar nuclei (Wang et al., 2018), but also in cerebellar cortex as the modulated excitability ...the response pattern, memory storage, and animal behaviors via branch- specific IP induction ...
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Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA damage response in Purkinje neuron progenitors
... the cerebellar primordium, especially flanking the ...for cerebellar development ( inter alia , see Aldinger et ...the cerebellar VZ, which contains PC precursors, progenitor cell bodies known ...
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Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse
... Analysis. All recordings were analyzed using WinWCP (as described above). To obtain average peak amplitudes of evoked synaptic currents, at least 50 consecutive currents were averaged, including any failures. The ...
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The sodium potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron
... the Purkinje cell response to ouabain (real or simulated), the duration of the trimodal pattern’s silent periods became shorter until firing was continuous ...
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Factors shaping excitatory synaptic currents in cerebellar Purkinje cells
... the response to D-aspartate if it had been produced by glutamate-gated ...in cerebellar Purkinje cells when glutamate analogues activating metabotropic glutamate receptors were ...the cell on ...
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Immunolocalization of Ephexin 1 in the Developing Canine Cerebellum
... of cerebellar development until ...of Purkinje cells is thought to be a prerequisite for cerebellar motor ...of Purkinje cells with the maturation of the actin nucleator, Cobl ...ephexin-1, ...
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Results: Glia cells and Purkinje cells colocalized with dystrophin, however,
... With the NeuN labelling, the neuronal cells were not distinguishable. The cell density seems to be very high and the cells blurry. This could be caused by the use of a widefield fluorescence microscope, BX51, so ...
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Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells
... in Purkinje cells (PCs) of the cerebellum as well as other neurons in the central nervous system, and the formation of intracellular polyglutamine aggregates result in the loss of neurons as well as deterioration ...
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Does Intake of Ethanol and Khat (Catha Edulis Forsk) Affect the Total Number of Purkinje Neurons in Early Postnatal Rats?
... of Purkinje neurons and volume of cerebellar cortex, animals of postnatal day 6 were ...of cerebellar cortex and numerical density of Purkinje neurons, ...of Purkinje neurons was ...
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Brain Neurotransmitters and Neuromodulators in Pediatrics
... GABA, the most prevalent inhibitory neurotransmitter in the brain, is located in stellate neurons within all layers of the. cortex as well as in cerebellar Purkinje neurons.#{176}’9’[r] ...
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Calbindin in cerebellar Purkinje cells is a critical determinant of the precision of motor coordination
... in Purkinje cells and acts here as a powerful Ca 2⫹ buffer (Fierro and Llano, 1996; Airaksinen et ...the Purkinje cell-specific calbindin null ...of cerebellar synaptic ...3 Purkinje ...
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Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model
... ebellar Purkinje cells, but also in cerebellar Golgi ...ule cell inhibition is specifically manipulated (38), we hypothesize that tonic Golgi cell inhibition of cerebellar granule cells ...
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Neuroprotection by taurine in ethanol-induced apoptosis in the developing cerebellum
... Two major apoptotic pathways have been established: the death-receptor-mediated and the mitochondrial- mediated apoptosis [28], also known as the “ extrinsic ” and as “ intrinsic ” apoptotic pathways, respectively [30]. ...
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Estimation of Purkinje cell quantification and volumetry in the cerebellum using a stereological technique
... Estimating total cell numbers may give valu- able information on cell population dynamics dur- ing development or specific pathological circum- stances. Considering the clinical and laboratory experiences ...
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