Cervical Carcinogenesis
MDM2 SNP309 (rs2279744) and p53 Codon Arg72Pro (rs1042522) SNP in Cervical Carcinogenesis
... with cervical carcinogenesis in a Japanese population particularly in high-risk HPV ...of cervical neoplasias in a setting of longitudinal cohort study and for the determination of appropriate ...
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An amino bisphosphonate targets MMP 9–expressing macrophages and angiogenesis to impair cervical carcinogenesis
... established cervical cancer so as to elicit stasis or regression rather than progression and ...in cervical tumors by targeting both macrophage expres- sion and proteolytic activity of an MMP, ...and ...
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Original Article The expressions of DNA methyltransferase 1 (DNMT1) and cyclin A1 (CCNA1) in cervical carcinogenesis
... The expressions of DNMT1 and CCNA1 mRNA in the process of cervical carcinogenesis was measured by qPCR (Figure 6). The amplification product was single and had a strong specificity. As shown in Table 5, the ...
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RETRACTED ARTICLE: Molecular mechanisms in progression of HPV-associated cervical carcinogenesis
... in cervical cancer patients showed that differ- ent doses of hydralazine treatment was well-tolerated and effective to demethylate and reactivate the ex- pression of eight tumor suppressor genes without af- ...
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Cytokeratin7 and cytokeratin19 expression in high grade cervical intraepithelial neoplasm and squamous cell carcinoma and their possible association in cervical carcinogenesis
... During HPV life cycle, the viral replication and the ex- pression of viral genes are closely tied to the differenti- ation program of host epithelial cell [1]. In this process, CK network appears to be reorganized and ...
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The association between methylated <em>CDKN2A</em> and cervical carcinogenesis, and its diagnostic value in cervical cancer: a meta-analysis
... model was applied to calculate the association of methylated CDKN2A with cervical cancer. Our results indicated that the frequency of methylated CDKN2A in cervical cancers was significantly higher than in ...
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Original Article The functional role of RNF113A in cervical carcinogenesis
... The tumor suppressor protein p53 is encoded by the TP53 gene the function of which is to induce cell cycle arrest and apoptosis with sev- eral target genes, including p21, BAX and Fas [18]. The half-life of p53 is very ...
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Ubiquitin specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis
... with cervical cancer, and the levels of these 2 factors positively correlated with each ...of cervical cancers are associated with HPV infection, the incorporation of which results in a defective G 1 /S ...
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circ_0084927 promotes cervical carcinogenesis by sponging miR-1179 that suppresses CDK2, a cell cycle-related gene
... circ_0084927 was selected as the circRNA of interest in CC We analyzed the GSE102686 data series using the GEO2R algorithm and identified 21 differentially expressed genes (DEGs). The top five most significantly up-regu- ...
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Identification of Candida Species in the Clinical Laboratory: A Review of Conventional, Commercial and Molecular Techniques
... Education also promotes several habits which further established as risk factors such as age at first sexual intercourse (AFSI), early age at first pregnancy and high parity. In addition to these, next factor abortion is ...
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Identification of lysine acetylome in cervical cancer by label-free quantitative proteomics
... in cervical cancer tissues compared with adjacent normal tissues (Fold change > 2 and P < ...viral carcinogenesis, RNA trans- port, and Jak-STAT, which play an important role in tumor ...in ...
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Human beta-defensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-κB signaling
... in cervical cancer samples and correlates with disease stages, we speculated that hBD3 may contribute to the cervical ...of cervical cancer cells by an overexpression ...these cervical cancer ...
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Identification of a long non-coding RNA NR_026689 associated with lung carcinogenesis induced by NNK
... lung carcinogenesis induced by NNK, we selected 3 pairs of rat lung tumor samples and matched normal lung tissues and 2 blood samples from the control and NNK treatment group in the 95th week, and determined the ...
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Hypermutability in Carcinogenesis
... If one assumes that expected frequency of a newly arising mutation in a tumor might be, considering that a sufficient number among the tumors with multiple p53 mutations, silent.. mutati[r] ...
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Esophageal Carcinogenesis
... b-1 Normal esophageal squamous epithelium; b-2 Squamous cell hyperplasia; b-3 Mild dysplasia; b-4 moderate dysplasia; b-5 Severe dysplasia; b-6 Squamous cell papilloma; b-7 Squamous cell[r] ...
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NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration, and Chemoresistance
... Since tobacco is a well characterized risk factor for oral cancer, we investigated whether NGAL is regulated by tobacco carcinogens. The main carcinogens characterized from tobacco smoke include benzo[a]pyrene, ...
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Original Article Expression of aquaporin 8 and phosphorylation of Erk1/2 in cervical epithelial carcinogenesis: correlation with clinicopathological parameters
... than cervical carcinoma, and lowest in normal tis- sues at both transcription and translation lev- ...in cervical carcinoma with clinicopath- ological ...
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Genetic Determination of Susceptibility to Estrogen-Induced Mammary Cancer in the ACI Rat
... susceptibility to 7,12-dimethylbenz[a]anthracene (DMBA)- early and contributory event in E2-induced mammary induced mammary cancer have been mapped to RNO1, carcinogenesis (B. Xie and J. D. Shull, unpublished -2, ...
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Original Article Low expression of long non-coding RNA LET inhibits carcinogenesis of cervical cancer
... in cervical cancer, cor- relation between lncRNA LET expression and clinicopathological features such as age, tumor size, histology, tumor differentiation, FIGO stage, lymph node metastasis and depth of ...
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Mammary stem cells, self renewal pathways, and carcinogenesis
... There is increasing evidence that both stem and progenitor cells may be the targets of transformation during carcinogenesis. As described above, normal stem cells and cancer cells share several important ...
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