cGMP-dependent protein kinase
Natural variation in food acquisition mediated via a Drosophila cGMP dependent protein kinase
... quality can change drastically over time, animals must continuously alter their food acquisition strategies. Although genetic variation contributes to this plasticity, the specific genes involved and their interactions ...
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Expression of type II cGMP dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression
... messenger cGMP normally increase natriuresis and diuresis, and regulate renin release; however, the severe pathological state of cardiac heart failure is characterized by elevated levels of atrial natriuretic ...
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Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMP
... of cGMP-dependent protein kinase (PKG) in the modu- lation of vascular smooth muscle cell (SMC) prolifera- tion and apoptosis in ...augment kinase activity in cultured rat pulmonary ...
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Endogenous expression of type II cGMP dependent protein kinase mRNA and protein in rat intestine Implications for cystic fibrosis transmembrane conductance regulator
... increase cGMP, and elicit life-threatening secretory ...of cGMP actions has not been ...II cGMP dependent protein kinase (cGK II) which is highly enriched in intestinal ...and ...
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cGMP-dependent protein kinase Iα associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake
... In RN46A cells, we established using qualitative and quantitative approaches that endogenous PKGI and SERT colocalize. Although PKGII could not be detected by RT- PCR, low levels of PKGII immunoreactivity were evident ...
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Phosphorylation of GSK 3β by cGMP dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
... vitro kinase assay using a serine/threo- nine kinase substrate ...polo-like kinase (PLK), 90-kDa ribo- somal protein S6 kinase (p90RSK), eNOS, GSK-3β, vasodilator-stim- ulated ...
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Phosphoinositide Metabolism Links cGMP- Dependent Protein Kinase G to Essential Ca (2+) Signals at Key Decision Points in the Life Cycle of Malaria Parasites
... In this study we demonstrate that PKG is the cGMP effector kinase that regulates gliding of P. berghei ookinetes downstream of GCb and PDEd. Ookinetes are relatively tractable cells by both biochemical and ...
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Haas, Bernd-Bodo (2008): Role of cGMP-dependent protein kinase in brown fat cell differentiation. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... However, protein synthesis-dependent late phase of LTP was impaired after multiple episodes of strong theta burst stimulation in adult hippocampus-specific PKGI knock out mice (Kleppisch et ...
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Activation of HIV 1 expression and replication by cGMP dependent protein kinase type 1 β (PKG1β)
... To verify more physiologically the above LTR-reporter assay, we next checked the effect of PKG1β on an HIV-1 infectious molecular clone, pNL 4-3 (Figure 1B). Here, increasing amounts of PKG1β-plasmid were transfected ...
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cGMP dependent changes in phototaxis: a possible role for the foraging gene in honey bee division of labor
... a cGMP- dependent protein kinase ...and cGMP treatment (which increases PKG activity) causes precocious ...and cGMP treatment caused a precocious onset of positive phototaxis. ...
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Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L ): cloning, tissue expression and comparative aspects
... cAMP/cGMP-dependent protein kinase phosphorylation motif close to membrane-spanning domain IX (found in all vertebrate sequences with the exception of the human) and the adjacent ...
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The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans
... the cGMP-dependent protein kinase ...EGL-4 kinase is activated by cGMP (Stansberry et ...that cGMP produced by the GCY-12 guanylyl cyclase activates EGL-4 in ...the ...
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Modulation of basal nitric oxide dependent cyclic GMP production by ambient glucose, myo inositol, and protein kinase C in SH SY5Y human neuroblastoma cells
... Possible mechanisms linking AR activation to NO deficiency include competition between AR and NOS for NADPH cofac- tor (13), and/or d -glucose–induced alterations in PKC activity, which in turn appears to modulate NOS. ...
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Endothelial nitric oxide synthase: a potential therapeutic target for cerebrovascular diseases
... /calmodulin-dependent protein kinase kinase- β ; Cav-1: caveolin-1; CBF: cerebral blood flow; cGMP: cyclic guanosine monophosphate; DCI: delayed cerebral ischemia; eNOS: endothelial ...
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Toxoplasma gondii Cyclic AMP Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development
... is dependent on a TgPKAc3 ...cAMP- dependent tachyzoite maintenance was ...the protein lysate from parental parasite Pru ⌬ ku80 ⌬ hxgprt (Parent), knockout clone Pru ⌬ ku80 ⌬ pkac3 (PKAc3KO), and ...
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Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... demonstrated that doxycycline withdrawal resulted in suppression of mir-155 expression and subsequent tumor shrinkage [89]. In this mouse model, anti-miR- 155 treatment resulted in decreased tumor burden, indi- cating ...
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An investigation into the mecanisms mediating calcium ion stimulated ACTH secretion from AtT 20 anterior pituitary tumour cells
... concentration- dependent manner becoming significantly greater than control secretion at concentrations above lO’^M (figure ...GTP-binding protein (or proteins) contributes to ACTH secretion from AtT-20 ...
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Stimulation of porcine jejunal ion secretion in vivo by protein kinase C activators
... calcium dependent, cyclic nucleotide independent pathway that is postulated to involve protein kinase C activation, we measured protein kinase C activity and phorbol ester binding in ...
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Plasmodium falciparum Calcium Dependent Protein Kinase 2 Is Critical for Male Gametocyte Exflagellation but Not Essential for Asexual Proliferation
... (KO-C1) and clone C13 (KO-C13) parasite (iii) is shown. A common forward oligonucleotide (F3) specific to the 5=-UTR of PfCDPK2 was used for all of the amplifications. Reverse oligonucleotide R1 specific for the deleted ...
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Wörner, René (2006): Mechanismen der cGMP-induzierten Relaxation der Mausaorta. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Die cGMP-abhängige Proteinkinase (cGK) gehört zur Familie der Serin/ Threonin- Kinasen, welche die Aminosäuren Serin und Threonin eines Substrats spezifisch ...die cGMP-abhängige Proteinkinase Typ I (cGKI) ...
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