checkpoint inhibitors
Checkpoint inhibitors in hematological malignancies
... immune checkpoint inhibitors in patients with hematologic cancers are under ...immune checkpoint inhibitors in patients with certain cancers, not all patients respond to immune ...
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Systemic inflammation in a melanoma patient treated with immune checkpoint inhibitors—an autopsy study
... Case presentation: This autopsy case illustrates that clinically overt irAEs may represent only a fraction of the total spectrum of immune-related organ pathology in patients treated with immune checkpoint ...
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A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors
... immune checkpoint inhibitors ...to checkpoint inhibitors in GC ...immune checkpoint inhibitors may be useful for the treatment of diffuse-type C-II GCs, but may not good for C-I ...
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Checkpoint inhibitors for malignant melanoma: a systematic review and meta-analysis
... and/or checkpoint inhibitors, were not original research, were not available in English, or had a clearly inappropriate study design accord- ing to the inclusion and exclusion criteria were ...
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Emerging Role of Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
... immune checkpoint inhibitors, the addition of immune checkpoint inhibitors after resection or during locoregional therapy, immune checkpoint inhibitors in addition to kinase ...
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Immune checkpoint inhibitors of PD-L1 as cancer therapeutics
... immune checkpoint inhibitors including ate- zolizumab are only effective in a subset of patients, and some patients who respond initially show a subsequent rapid disease progression due to primary and ...
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Immune checkpoint inhibitors in the treatment of virus-associated cancers
... immune checkpoint inhibitors (ICIs) in recent years has opened a new door to cancer ...of checkpoint inhibitors in the treatment of virus-related cancers is ...
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Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer
... Although several immune-checkpoint inhibitors are now available in clinical practice, the place of cancer immuno- therapy is unclear. It is not often evident which patients will benefit from immune ...
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Cardiotoxicity of immune checkpoint inhibitors
... Immune checkpoint inhibitors are a novel class of anticancer drugs, distinct from targeted or tumour type-specific ...immune checkpoint blockers (ie, monoclonal antibodies targeting cytotoxic T ...
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Gut microbiome modulates efficacy of immune checkpoint inhibitors
... Immune checkpoint inhibitors (ICIs) therapy is a novel strategy for cancer treatments in recent years. However, it was observed that most patients treated with ICIs could not get benefit from the therapy, ...
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Management of pulmonary toxicity associated with immune checkpoint inhibitors
... death-1 inhibitors in lung cancer, melanoma, renal cell carcinoma, Hodgkin ’ s lymphoma, bladder, head and neck ...immune-checkpoint inhibitors, the incidence of immune toxicity will continue to ...
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Advances in Research on Immunological Checkpoint Inhibitors in Immunotherapy of Liver Cancer
... immunological checkpoint inhibitors can be combined with hepatic artery embolization chemotherapy or as an adjuvant therapy after surgical resection or radiofrequency ...
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Prospect of the use of checkpoint inhibitors in hepatocellular cancer treatments
... immune checkpoint inhibitors (cytotoxic T-lymphocyte antigen 4, programmed death 1, and programmed death-ligand 1) has opened a new horizon for cancer ...immune checkpoint inhibitors, cancer ...
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Antibiotic therapy and outcome from immune-checkpoint inhibitors
... Immune-checkpoint inhibitors; LPS: Lipopolysaccharide; MHC: Major Histocompatibility Complex; NOD1: Nucleotide-binding oligomerization domain-containing protein 1; NSCLC: Non-small Cell Lung Cancer; ORR: ...
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Checkpoint inhibitors in the treatment of urological malignancies
... in checkpoint inhibitors in the treatment of mUC and mRCC, the majority of patients are still not experiencing any bene- fits, while others have achieved long-term ...
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Immunotherapy and checkpoint inhibitors for gliomas
... with checkpoint inhibitors may provide a more robust response with better survival ...with checkpoint inhibitors, and will hopefully elucidate the benefit of these combined therapies ...
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Oncolytic viruses and checkpoint inhibitors: combination therapy in clinical trials
... Current-generation oncolytic viral vectors can be engi- neered to target specific types of cancer cells, selectively replicate within them, and locally express a transgene [11]. The tumor tropism of a virus is a key ...
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Combination systemic therapies with immune checkpoint inhibitors in pancreatic cancer: overcoming resistance to single-agent checkpoint blockade
... Immune checkpoint inhibitors have demonstrated broad single-agent antitumor activity and a favorable safety profile that render them attractive agents to combine with other systemic anticancer ...of ...
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Cancer immunotherapy beyond immune checkpoint inhibitors
... Indoleamine 2,3-dioxygenase (IDO) is an enzyme that converts tryptophan to kynurenines. These latter pro- mote the formation of Tregs, increase the number of MDSCs, and decrease the activity of CD8 T cells with a ...
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Budesonide treatment for microscopic colitis from immune checkpoint inhibitors
... Immune checkpoint inhibitors (CPIs) are highly effective against a range of advanced malignancies, but are also associated with treatment-limiting inflammatory toxic- ities termed “immune-related adverse ...
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