Chemical compounds selected from high-throughput screening
High throughput biodegradation screening test to prioritize and evaluate chemical biodegradability
... Analysis. High through- put biodegradation tests may also enable the generation of extensive and reliable biodegradation half-life data that could be used to develop and validate in silico ...for selected ...
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High-Throughput Chemical Screening for Antivirulence Developmental Phenotypes in Trypanosoma brucei
... molecules from throughout the signaling cascade, including kinases, phosphata- ses, and at least one predicted RNA binding protein ...outputs from high-throughput small-compound screens such ...
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Advances in high-throughput screening: better compounds, novel targets, enhanced sensors
... assay from individual tests performed by micropipette to a high-throughput method employing automated robotic liquid handlers introduced additional complications of signal variation and ...signal ...
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A high throughput screening of a chemical compound library in ovarian cancer stem cells
... a chemical compound library assembled during the COST CM1106 action to search for compound classes active in targeting ovarian stem ...the high-throughput screening assay in two ovarian cancer ...
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A high-throughput screening of a chemical compound library in ovarian cancer stem cells
... most high-grade serous ovarian cancer (~80%) originates in the ovarian fimbriae [10, ...shed from papillary tufts, and may implant on the surface of the ...of high-grade serous carcinoma (HGSC) ...
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A High Throughput Screening Platform for Skin Tuning Properties from Natural Products: Identification of Skin Tanning Compounds
... originated from two different communities, the two areas share a same goal—skin colour ...safe compounds with skin colour tuning activities are ...bioactive compounds, which have been used in Asian ...
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High-Throughput Microsomal Stability Assay for Screening New Chemical Entities in Drug Discovery
... Several attempts have been made to overcome this limita- tion, such as cassette dosing, pooling analysis, and 2-time- points methods, among others. 10,11 Cassette dosing consists of pooling different drugs in the same ...
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Identification of thyroid hormone receptor active compounds using a quantitative high-throughput screening platform.
... quantitative high-throughput screening (qHTS) platform, we miniaturized the reporter gene assay to a 1536-well plate ...chemicals from the Library of Phar- macologically Active ...
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High throughput screening in niche based assay identifies compounds to target preleukemic stem cells
... for high drug attri- tion rates when it comes to efficacy in clinical trials ...this high attrition rate, our results suggest that cell line–based screen- ing as well as 2-dimensional screening ...
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High-content, high-throughput screening for the identification of cytotoxic compounds based on cell morphology and cell proliferation markers.
... if compounds with cytotoxic characteristics were identified during primary compound ...of high-content imaging in primary screening is becoming more widespread, and by utilising phenotypic approaches ...
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A Mechanistic Framework for Integrating Chemical Structure and High-Throughput Screening Results to Improve Toxicity Predictions
... gathered from the ...NR from Mellor et ...assay from the final hit-call ...each chemical and; 4) a number of chemical ...those chemical with a defined structure and corresponding ...
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Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes
... cost-effective high- throughput reporter gene assay to identify compounds active against late-stage (stage IV and V) ...10,000 compounds from three chemically diverse librar- ies. The ...
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Bacterial Microcolonies in Gel Beads for High-throughput Screening.
... cells from the same bead. The chemical would also enter neighboring beads, where the molecule is not ...separated from the free bacteria might become ...
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High throughput screening (hts) assays: uses and formats
... of high throughput screening (HTS) assays, the time taken to evaluate the potential bioactivity and usefulness of compounds to act on target molecules and become drugs to act to ameliorate ...
High-Throughput Screening: Effective Tool in Drug Discovery
... and High-Throughput Screening or HTS allows a researcher to quickly conduct millions of biochemical, genetic or pharmacological reactions or ...HTS screening libraries or "decks" can contain ...
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Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection.
... of compounds is known to confound the perform- ance of ...conditions, from the same compound stocks, Figure 1. Phenotypic screening cascade of the compound ...000 compounds. Subsequent pro ...
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High-throughput screening to enhance oncolytic virus immunotherapy
... sensitizer compounds – including anagrelide, ebselen, flu- phenazine, and indirubin – were identified that synergistically enhanced oncolytic activity across gCSC ...sensitizer compounds were further ...
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Intein mediated high throughput screening for bispecific antibodies
... derived from early stage screening campaigns are based on a scFv, VHH or Fab format selected by for example yeast surface display or phage display derived from bacterial ...Functional ...
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High-Throughput Screening for Phase-Change Memory Materials
... materials selected from 124 515 samples after searching all the four ...is from the elements in IVA, VA, VIA ...sources from the ever reported PCM mate- rials as listed in Table S1, Supporting ...
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Development of a high-throughput method of analysis for selected neonicotinoids
... the screening of analytes in environmental ...the high temperature metastable gas causes thermal desorption of analytes from the thin-film surface, the analytes are then ionized and introduced into ...
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