Chemokine signaling
Cxcl12/Cxcr4 chemokine signaling is required for placode assembly and sensory axon pathfinding in the zebrafish olfactory system
... Cxcl12/Cxcr4 signaling may play a role in olfactory ...Cxcl12/Cxcr4 signaling mediates the assembly of olfactory placodal precursors into a compact cluster to form the olfactory placode in ...Cxcl12/Cxcr4 ...
10
Chemokine signaling in embryonic cell migration: a fisheye view
... Another effect of chemokines on cell migration involves their control of integrin-mediated adhesion (Ley et al., 2007; Luo et al., 2007). This effect is considered to be mediated by the rapid modulation of the affinity ...
7
Chemokine signaling in development and disease
... that chemokine signaling also guides the migration of neurons, neural crest cells and germ cells during embryonic development, regulates the patterning and remodeling of the vascular system, and attracts ...
7
Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis
... follow chemokine gradients, which direct the cells toward the site of ...the chemokine signaling pathway (CCL4/CCR5/c-Jun and c-Fos/CCL2) play a role in chemoattractants for PB leukocytes into joint ...
9
Arterial venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling
... Notch signaling, in controlling ...that chemokine signaling specifically controls arterial-venous network formation in the ...the chemokine receptor cxcr4a or its ligand cxcl12b establish a ...
10
CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms
... Accumulating evidence has shown that both cancer invasion and metastasis are directly linked to activation of cofilin, which is regulated by phosphorylation status on Ser3 [43]. Cofilin and ADF (actin-depolymerization ...
14
Sonic hedgehog is indirectly required for intraretinal axon pathfinding by regulating chemokine expression in the optic stalk
... Hh signaling was shown to promote the expression of chemokine pathway components at the level of cxcl12 and cxcr4 in cholangiocyes, endothelial progenitor cells and medulloblastoma (Omenetti et ...between ...
10
G protein coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts
... targeting chemokine signaling hold promise for the management of several malignancies characterized by aberrant ...in chemokine-dependent tumor angiogenesis is a topic under intense investigation, ...
28
Serum cytokine profiling analysis for zheng differentiation in chronic hepatitis B
... and chemokine signaling pathway overlapped between LGDH and LKYD, whereas Toll‑like receptor signaling pathway, intestinal immune network for IgA production, NOD‑like receptor signaling ...
10
Activation of IL-8 and its participation in cancer in schizophrenia patients: new evidence for the autoimmune hypothesis of schizophrenia
... and cancer, specifically genes coding for IL-8, PTGS2, TPR, JUN, CXCL1, CXCL3, CXCL5 and PARD3, all of which showed increased expression in schizophrenia patients. Furthermore, we also observed that cancer- and ...
11
The Genetic, Molecular, And Cellular Bases Of Unidentified Primary Immunodeficiencies
... for chemokine mediated leukocyte migration as well as regulating development, inflammation, and metabolism in the immune system and ...impaired chemokine signaling and chemotaxis in addition to ...
172
Convergence of signaling pathways underlying habenular formation and axonal outgrowth in zebrafish
... the chemokine ligand Cxcl12a (Class II ...Cxcr4b- chemokine signaling pathway is not required for the generation of dHb neurons, it is necessary for the correct outgrowth of their efferent ...
11
Replicon Particles of Venezuelan Equine Encephalitis Virus as a Reductionist Murine Model for Encephalitis
... The model has unequivocally identified neurons as the major target of VEE infection in the CNS, has begun to elucidate the pattern of intercellular cytokine and chemokine signaling in in[r] ...
12
Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity
... the chemokine Cxcl12a and the Rho GTPase Rac1, ...that signaling mediated by G protein subunits G is required to regulate cell ... signaling failed to polarize, and developed multiple protrusions ...
6
The Carboxy-Terminal Tail of Human Cytomegalovirus (HCMV) US28 Regulates both Chemokine-Independent and Chemokine-Dependent Signaling in HCMV-Infected Cells
... The cytoplasmic carboxy-terminal region of US28 has been identified as an important regulator of US28 signaling (36, 40, 53). This 40-amino-acid carboxy-terminal region contains sev- eral clusters of Ser/Thr ...
12
The effect of caveolin-1 knockdown on interleukin-1β-induced chemokine (C-C motif) ligand 2 expression in synovial fluid-derived fibroblast-like synoviocytes from patients with rheumatoid arthritis
... Looking at all the research conducted on animal mod- els, it can be concluded that CCL2 expression is CAV1- dependent, but only to a certain extent. Our results sug- gest that CCL2 secretion by sfd-FLSs obtained from RA ...
7
Chemokine CXCL12 activates dual CXCR4 and CXCR7 mediated signaling pathways in pancreatic cancer cells
... show signaling through either pathway leads to an increase in cell proliferation upon exposure to ...CXCL12 signaling in pancreatic cancer should be focused at the level of the ligand to account for both ...
9
Differential signaling mechanisms regulate expression of CC chemokine receptor-2 during monocyte maturation
... of chemokine receptors CCR1-CCR9 and CXCR1-CXCR5 by PCR using primers designed ...for chemokine receptors CCR1-CCR9, CXCR1-CXCR5 and ...in chemokine receptor expression by flow ...
14
Rabies Virus-Induced Activation of Mitogen-Activated Protein Kinase and NF-κB Signaling Pathways Regulates Expression of CXC and CC Chemokine Ligands in Microglia
... M each) and infected with CVS-11 virus. At 24 h postinfection, the cells were fixed, and the percentages of virus plating were determined with reference to the values for the drug-untreated control. (D) I B–NF- B ...
12
Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
... Fig. 1 Analyses of potential alterations in key inflammatory targets in the peripheral blood mononuclear cells (PBMCs) of Parkinson ’ s disease (PD) patients relative to healthy donors (HDs). a Schematic depicting ...
5