Chemotherapeutic Agent
Lapatinib promotes the incidence of hepatotoxicity by increasing chemotherapeutic agent accumulation in hepatocytes
... plus chemotherapeutic agent were significantly higher than those in the group of single chemotherapeutic agent such as paclitaxel or ...
15
Resveratrol alleviates oxidative damage in enteric neurons and associated gastrointestinal dysfunction caused by chemotherapeutic agent oxaliplatin
... Oxaliplatin is a first-line chemotherapeutic agent used for the treatment of colorectal cancer. Its use is associated with severe gastrointestinal (GI) side-effects, associated with oxidative damage and ...
15
Cetuximab enhanced the efficacy of chemotherapeutic agent in ABCB1/P-glycoprotein-overexpressing cancer cells
... substrate chemotherapeutic agent in a concentrationdependent manner, but did not potentiate the cytotoxicity of non substrate chemotherapeutic agent such as ...of chemotherapeutic ...
16
A model of hematopoietic stem cell proliferation under the influence of a chemotherapeutic agent in combination with a hematopoietic inducing agent
... The model and accompanying analysis bring forth an interesting question that has ramifications in the field of oncology: Is concurrent administration of a HIA during chemotherapy a prudent approach for reducing toxicity ...
14
Role of L-Asparaginase as an Effective Chemotherapeutic agent for Acute Lymphoblastic Leukemia in Children’s
... Acute lymphoblastic leukemia is more common in children, accounting for 85% of childhood leukemias. The incidence of this disease is highest in the three to four year old age group, falling off by ten years. ...
11
Osmotic blood brain barrier disruption Computerized tomographic monitoring of chemotherapeutic agent delivery
... Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated therapeutic levels of drug in the ipsilat[r] ...
6
CHEMOTHERAPEUTIC AGENT-INDUCED OVARIAN GONADOTOXICITY Mona AM Helal
... Paclitaxel is effective against a variety of human tumours, including ovarian carcinomas (Wiseman & Spencer, 1998). Paclitaxel is classified as a "plant alkaloid," a "taxane" and an ...
9
The chemotherapeutic agent bortezomib induces the formation of stress granules
... McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ: Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiatio[r] ...
10
METFORMIN - A HYPOGLYCEMIC DRUG, AS AN EFFECTIVE CHEMOTHERAPEUTIC AGENT: A REVIEW
... The results indicate that metformin therapy was associated with an estimated reductionof 37% in the risk of colorectal cancer among patients with type 2 diabetes.In vi[r] ...
6
Modification of polyethylene glycol onto solid lipid nanoparticles encapsulating a novel chemotherapeutic agent (PK-L4) to enhance solubility for injection delivery
... Aims: To utilize solid lipid nanoparticles (SLNs) modified with polyethylene glycol (PEG) to improve the delivery of PK-L4 and investigate its biodistribution behavior after intravenous[r] ...
11
Gastric cancer vaccines synthesized using a TLR7 agonist and their synergistic antitumor effects with 5 fluorouracil
... Since T7 − MB was the most effective vaccine in this study, the synergistic effects of T7 − MB and 5-FU (a typical chemotherapeutic agent) on tumor challenge were further examined in vivo. Substantially ...
13
Synergistic effect of paclitaxel and epigenetic agent phenethyl isothiocyanate on growth inhibition, cell cycle arrest and apoptosis in breast cancer cells
... Breast cancer is the most commonly diagnosed cancer among women, accounting for more than 1 in 4 cancers [16]. After lung cancer, breast cancer is the leading cause of cancer death in women. Chemotherapy is a mainstay in ...
8
LncRNA HOTAIR induces sunitinib resistance in renal cancer by acting as a competing endogenous RNA to regulate autophagy of renal cells
... Autophagy, an intra-cellular self-defense mechanism can be used by tumor cells as a defense apoptotic cell death, which enhance the resistance of tumor cells to chemotherapeutic agent[r] ...
14
Hoffmann, Ruth (2010): Investigation of helenalin-induced cell death in Bcl-2 overexpressing Jurkat cells. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... As shown in Figure 7, helenalin induces cell death and abrogates clonogenic survival despite of elevated Bcl-2 levels in both cell lines, whereas other classical chemotherapeutic agent[r] ...
96
DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway
... Additional clinical features included microcephaly, vitiligo and hypoplasia of the testes [8]. After nearly four decades another article reported an accumulation of large number of chromatid breaks in the blood ...
10
MAGNETIC DRUG DELIVERY IN THERAPEUTICS
... a chemotherapeutic agent which could be selectively localized by applying an external magnetic field to specific target ...anticancer agent, methyl CCNU (1-(2-chloroethyl)-3- ...
11
Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles
... anticancer and antimicrobial effects of sulphated zirconia nanoparticles. The main purpose of this study was to prepare sulphated zirconia superacidic nanoparticles for use as a chemotherapeutic agent ...
10
“Chemotherapy of Breast Cancer by Heterocyclic Compounds” by Salam A. Mohammed, Firas Hassan, Anil K. Philip, Ayah Abdul Hameed, Emad Yousif, Sultanate of Oman.
... to chemotherapeutic agent is first-rate problem in the clinical handling of cancer; so a wide array of selective and potent compounds is required to fit the growth problems related to cancer 22 ...Most ...
7
Journal of Applied Pharmaceutical Science
... significant chemotherapeutic agent against DMBA induced skin cancer in wistar rats compared to that of paclitaxel by analyzing the lipid profile and lipid metabolizing enzymes and marker ...
5
Gold nanoparticles enhance TRAIL sensitivity through Drp1-mediated apoptotic and autophagic mitochondrial fission in NSCLC cells
... to chemotherapeutic agent, Calu-1 cells were incubated with TRAIL alone and in combination with AuNPs, and mitochondria were stained with MitoTracker Green FM, then the changes in mitochondrial network ...
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