Chemotherapeutic Agents
Effect of ceritinib (LDK378) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo
... doxorubicin and paclitaxel (both are ABCB1 substrates) in KBv200 cells and MCF-7/adr cells but did not alter the cytotoxicity of cisplatin which is not an ABCB1 substrate. The similar results were observed in the stably ...
17
Inhibition of HIV replication in vitro by clinical immunosuppressants and chemotherapeutic agents
... the chemotherapeutic, cytarabine, are potent antiretroviral agents at clinically relevant ...and chemotherapeutic agents may act combinatorially to inhibit HIV ...
6
Cell-based high-throughput screens for the discovery of chemotherapeutic agents
... To address this need, our laboratory recently developed the ATAD5-luciferase HTS assay [9], which exploits the stabilization of the ATAD5 protein following DNA damage [10]. This assay is robust and reproducible in a ...
5
Curcumin and its derivatives as chemotherapeutic agents
... A popular Indian spice, turmeric (Curcuma longa) has been used for centuries in herbal medicines for the treatment of a variety of disorders such as rheumatism, diabetic ulcers, anorexia, cough and sinusitis. Curcumin ...
18
CHITOSAN MICROSPHERES FOR THE DELIVERY OF CHEMOTHERAPEUTIC AGENTS: PACLITAXEL AS A MODEL
... the chemotherapeutic agents, especially those with unfavorable pharmacokinetic features, like paclitaxel (PTX), can potentially alleviate the systemic cytotoxicity as well as directing therapy to the ...
5
Phospholipid prodrug conjugates of insoluble chemotherapeutic agents for ultrasound targeted drug delivery
... Liposomes cannot typically be visualized using ultrasound and are primarily utilized as drug delivery vehicles. Liposomes can encapsulate various types of drugs (both hydrophilic and hydrophobic) within an aqueous core ...
17
SENSITIVITY OF SERUM ENZYME INHIBITORS TO A VARIETY OF CANCER CHEMOTHERAPEUTIC AGENTS
... As in Case 1, the enzyme inhibitor responses consistently preceded changes in the cell count of the peripheral blood, but in this more acute form of the disease the lag was only 24 to 48[r] ...
12
Chemotherapy-related complications in the kidneys and collecting system: an imaging perspective
... therapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrex- ate, semustine, streptozocin, mithramycin, and ...tain chemotherapeutic ...
9
Evaluation of Efficacy of L-Glutamine in the Management of Acute Radiation Induced Mucositis in Head and Neck Cancer Patients
... neoadjuvant chemotherapeutic drug regimen commonly used are TPF regimen [docetaxel 75 mg/m 2 , day 1; cisplatin 75 mg/m 2 , day 1; 5-fluorouracil 500 mg/ (m 2 ...alkylating agents, antimetabolites and ...
124
Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer
... We have demonstrated here and elsewhere [42] that co- delivery of reovirus with chemotherapeutic agents with a variety of modes of actions is able to enhance in vitro cyto- toxicity in a synergistic manner. ...
9
Synergy between histone deacetylase inhibitors and DNA- damaging agents is mediated by histone deacetylase 2 in colorectal cancer
... DNA-targeted chemotherapeutic agents and HDAC inhibitors (HDACis) on two TP53-mutated colorectal adenocarcinoma CRC cell lines (SW480 and HT-29) and on the TP53-wild type carcinoma cell line (HCT116 p53+/+) ...
17
Burstin, von, Vivian Annaluise (2011): PKC isozymes in the control of fate of prostate cancer cells. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Cleaved PKC δ can also translocate to the nucleus in response to chemotherapeutic agents, which is due to the exposure of a cryptic nuclear localization signal (NLS) locate[r] ...
147
Cancer stem cell–associated miRNAs serve as prognostic biomarkers in colorectal cancer
... confers chemotherapeutic resistance in CRC, and this effect was in part attributable to CSC-like character- ...to chemotherapeutic agents and that these cells exhibit a unique miRNA profile, which ...
16
Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP 1049C) in patients with advanced cancer
... weeks; chemotherapeutic agents, experimental drugs or radiation therapy (other than local radiotherapy not involving bone marrow reserves) within the 4 weeks prior to therapy; mitomycin C or nitrosoureas ...
7
<p>Novel Tumor Suppressor lncRNA Growth Arrest-Specific 5 (GAS5) In Human Cancer</p>
... to chemotherapeutic agents; interestingly, GAS5 promoted the apoptosis of triple-negative and oestrogen receptor-positive cells in the presence of dual PI3K/mTOR inhibitor, such as imati- nib, which may ...
16
Management of patients with end-stage renal disease undergoing chemotherapy: recommendations of the Associazione Italiana di Oncologia Medica (AIOM) and the Società Italiana di Nefrologia (SIN)
... of chemotherapeutic agents can be found at ...Those agents that mainly bind to plasma proteins are poorly dialysable due to the high molecular weight and structure assumed by the complex ...15 ...
8
The cytotoxic effect of typhonium flagelliforme and clinacanthus nutans on breast cancer cell line
... and chemotherapeutic agents; although they were found to be less effective with low survival rate of breast cancer patient and potential of long-term negative side effects (Rates, 2001; Moongkarndi et ...
33
Stress-induced endocytosis and degradation of epidermal growth factor receptor are two independent processes
... Consistent with our specula- tion, Zwang and Yarden [ 27 ] observed that p38 mediated stress-induced endocytosis of EGFR augmented cyto- toxicity produced by chemotherapeutic agents in [r] ...
10
Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo
... unrelated chemotherapeutic drugs and this significantly decreases the efficacy of can- cer chemotherapy ...numerous chemotherapeutic drugs out from cancer cells, thereby attenuating the efficacy of ...
16
Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway
... toward chemotherapeutic agents, including cisplatin, doxorubicin and epirubicin, are negatively regulated by overexpression of GSTP1 ...to chemotherapeutic agents or ...to ...
14