chitinase-like protein-3
Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice
... complementary 3’-UTR sequences of Chi3l1 wild-type and ...(F) protein in IL-6-stimulated iMAECs in the presence of miR-342-3p mimic (50 nM) or control-miR were ...= 3) and cell proliferation (n = 5) ...
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Diagnosis of cardiac surgery-associated acute kidney injury: differential roles of creatinine, chitinase 3-like protein 1 and neutrophil gelatinase-associated lipocalin: a prospective cohort study
... C-reactive protein; LOS: length of stay; SE: standard error; AKIN: Acute Kidney Injury Network; OR: odds ratio; RIFLE: risk, injury, failure, loss and end-stage; HR: hazard ratio; TIMP-2: tissue inhibitor of ...
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Promoter polymorphisms in the chitinase 3 like 1 gene influence the serum concentration of YKL 40 in Danish patients with rheumatoid arthritis and in healthy subjects
... 40 protein is still largely elusive. YKL-40 is a trans- membrane protein in which cleavaged components bind to an unidentified receptor and the expression of YKL-40 is regulated by various inflammatory ...
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Urinary chitinase 3 like protein 1 for early diagnosis of acute kidney injury: a prospective cohort study in adult critically ill patients
... this protein is secreted by mac- rophages within the kidney [46], while NGAL is secreted by specific cells of the distal nephron ...this protein has an apparent molecular weight of ±39–40 kDa [52, 53], and ...
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Chitinase 3–like–1 and its receptors in Hermansky Pudlak syndrome–associated lung disease
... The fibrotic response in BLOC-3 HPS patients resembles that of IPF (3, 10, 35). Studies from our laboratory and others have demonstrated that injury and apoptosis are prerequisites for the development of ...
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Chitinase 3 like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria
... CHI3L1 is a relatively new biomarker of AKI or altered renal function that has been investigated in the con- text of critical illness [32, 33], and sepsis [34]. However, CHI3L1 has been predominantly investigated as a ...
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Molecular biomarkers in multiple sclerosis
... CHI3L1: Chitinase-3-like-1; CIS: Clinically isolated syndrome; CNS: Central nervous system; CSF: Cerebrospinal fluid; CXCL13: C- X-C motif chemokine-13; DNA: Deoxyribonucleic acid; Ds: ...
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Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients
... reactive protein (CRP) serum levels, and with the levels of some proinflamma- tory cytokines, such as IL-6 and p40, which is the common subunit of IL12 and ...
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Screening and identification of resistance related proteins from apple leaves inoculated with Marssonina coronaria (EII. & J. J. Davis)
... by chitinase and beta-1, 3-glucanase can be significantly in- duced by infection, as shown in several pathosystems ...Thaumatine-like protein (L22), a class 5-PR protein (PR-5), has ...
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Development of robust targeted proteomics assays for cerebrospinal fluid biomarkers in multiple sclerosis
... per protein and the corresponding isotopically heavy labelled versions were ...one protein (chitinase-3-like protein 1), more than three heavy peptides were ordered given that ...
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Chitinase 3 like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25 Dihydroxyvitamin D3
... as chitinase 3-like 1 (CHI3L1), breast regression protein 39 (BRP- 39, murine analog) or human cartilage glycoprotein 39 ...Although chitinase-like, YKL-40 does not exhibit ...
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YKL-40 (Chitinase 3-like I) is expressed in a subset of astrocytes in Alzheimer’s disease and other tauopathies
... For quantification analysis of IHC stains, full-section scans were obtained with Pannoramic MIDI II (3DHis- tech, Budapest, Hungary). Cortical grey matter of each case was delimited blinded to clinical phenotypes. An ...
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A chitinase like protein from Sarcoptes scabiei as a candidate anti mite vaccine that contributes to immune protection in rabbits
... The protective effects of the rSsCLP5-based vaccine were assessed by grading the inflammatory response and measurement of the lesion area after challenge. Five days post-challenge, inflammation in most of the infested ...
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Koller, Barbara (2009): The role of the chitinase-like protein BRP-39 in allergic asthma. Dissertation, LMU München: Medizinische Fakultät
... Indergen, New York, NY) or alumn alone. This process was repeated 5 days later. After an additional seven days, the animals received three aerosol challenges (40 min a day, 3 consecutive days) with 1% OVA (w/v) in ...
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The Novel Sigma Factor Like Regulator RpoQ Controls Luminescence, Chitinase Activity, and Motility in Vibrio fischeri
... control chitinase activity in ...showed chitinase activity that was significantly lower (about 50%) than that of the wild type ...showed chitinase activity that was ...elevates chitinase ...
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Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1
... USF1 protein was significantly increased in both siChi3L1-treated A549 and H460 cell lines (Figure ...and protein levels were investigated after treatment of A549 and H460 cell lines with ...and ...
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Cerebrospinal fluid phosphorylated tau, visinin like protein 1, and chitinase 3 like protein 1 in mild cognitive impairment and Alzheimer’s disease
... The disorder of calcium homeostasis is considered to be one of the main characteristics of the pathophysi- ology of AD, and the pathogenesis of AD is closely re- lated to the calcium signaling pathway [27]. Therefore, ...
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Pivotal regulators of tissue homeostasis and cancer: macrophages
... (chitinase 3-like protein 1) protein specifically bound to the interleukin (IL)-13 receptor α2 chain (IL-13Rα2) of gastric and breast can- cer cells, thus promoting cancer metastasis ...
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Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40
... by chitinase-3-like 1 protein (CHI3L1), expressed in astrocytes and associ- ated with neuroinflammatory ...CSF protein levels, further studies are ne- cessary to find ways to improve ...
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Role of genetic variations of chitinase 3-like 1 in bronchial asthmatic patients
... in chitinase knockout mice were associated with increased eosinophil apop- tosis ...regression protein (BRP)-39, which is the murine equivalent of YKL-40, was induced by cigarette smoke exposure in a mouse ...
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