Chloride channel
Original Article Contribution of calcium-activated chloride channel to elevated pulmonary artery pressure in pulmonary arterial hypertension induced by high pulmonary blood flow
... calcium-activated chloride channel (CaCC) and pulmonary arterial hypertension (PAH) induced by high pulmonary blood flow remains ...following chloride channel blocker niflumic acid (NFA) ...
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Characterization of the target of ivermectin, the glutamate gated chloride channel, from Anopheles gambiae
... AgGluCl-b encodes a rapidly activating glutamate-gated chloride channel sensitive to micromolar concentrations of glutamate and requires cooperative glutamate binding for activity. These characteristics are ...
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Functional repair of a mutant chloride channel using a trans splicing ribozyme
... of chloride channel ...ion channel for repair, we can direct- ly assess restored protein activity in single cells using electrophysiological ...record chloride currents in T268M-stable cells ...
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The Insecticide Avermectin Bla Activates A Chloride Channel in Crayfish Muscle Membrane
... Results Reversible effects of AVM We have recently shown that the three transmitters, GABA, glutamate and acetylcholine, activate a chloride channel in excised outside-out patches of cra[r] ...
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Expression of the chloride channel CLC K in human airway epithelial cells
... ClC channel types, these currents actually reflect the ensemble activity of sev- eral different channel types, among which ClC-K channels play a dominant ...detect chloride channel ...
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The swelling activated chloride channel ClC 2, the chloride channel ClC 3, and ClC 5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells
... additional chloride channels: ClC-2, ClC-3 and ClC-5, in the adult rat ...ClC-2 chloride channel can be regulated by changes in the osmolality of the environment ...ClC-3 chloride ...
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Localization and functional characterization of rat kidney specific chloride channel, ClC K1
... Expressed chloride current in Xenopus oocytes by ClC-K1 cRNA was regulated by extracellular pH and extracellular ...of chloride transport in ...transepithelial chloride transport in ...
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Requirement for Chloride Channel Function during the Hepatitis C Virus Life Cycle
... level in parental Huh7 cells (gray bars), consistent with an FIG 1 Assessment of ion channel modulators on HCV replication. SGR–Feo–JFH-1 cells stably expressing a luciferase subgenomic replicon (genotype 2a) were ...
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Chloride channel diseases resulting from impaired transepithelial transport or vesicular function
... ClC-K/barttin: basolateral chloride channels in kidney and inner ear epithelia The importance of the Cl– channels ClC-Ka/barttin ClC-K1/barttin in rodents and ClC-Kb/barttin ClC-K2/bartt[r] ...
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Requirement for chloride channel function during the hepatitis C virus life cycle
... Given these data, we investigated the molecular identity of the Cl ⫺ channel(s) required during the HCV life cycle. To date, nearly 40 different genes that, when expressed, increase Cl ⫺ conductance have been ...
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Overexpression of chloride channel-3 predicts unfavorable prognosis and promotes cellular invasion in gastric cancer
... In this study, the clinical significance and biological func- tion of CLC-3 in gastric cancer was investigated and it was demonstrated that 1) CLC-3 was upregulated in gastric cancer t[r] ...
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Permeation through the CFTR chloride channel
... the channel, without affecting gating properties, and (ii) that the engineered cysteines that react with the water-soluble reagent do so because they line the water-filled permeation pathway, rather than lining a ...
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Identification and regulation of the cystic fibrosis transmembrane conductance regulator generated chloride channel
... Cystic fibrosis transmembrane conductance regulator (CFTR) generates cAMP-regulated Cl- channels; mutations in CFTR cause defective Cl- channel function in cystic fibrosis epithelia. We used the patch-clamp ...
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A Novel Natural Product Compound Enhances cAMP-Regulated Chloride Conductance of Cells Expressing CFTRΔF508
... Using the yeast two-hybrid system (29), we tested whether CFTR NBD1, in the absence of other CFTR domains, could form homodimers and thereby acti- vate transcription of the HIS3 reporter gene. CFTR NBD1 and the upstream ...
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Role of ClC-2 and NHE transport proteins in Intestinal Mucosal Barrier
... The Chloride channel ClC-2 and sodium hydrogen exchanger NHE2 are members of large ClC and NHE families respectively, and their physiological function are not yet fully ...
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A novel missense mutation in the CLCN7 gene linked to benign autosomal dominant osteopetrosis: a case series
... the Chloride Channel 7 gene in the index patient (Case 1), whereas other mutations were not detected in the associated genes TCIRG1, OSTM1, RANK, and ...
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Chloride channels of intracellular organelles and their potential role in cystic fibrosis
... If CFTR is the chloride channel or a closely associated protein, then we would expect the trans Golgi and other vesicles to contain CFTR in normal cells and their acidification should be[r] ...
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Elevated expression of chloride intracellular channel 1 is correlated with poor prognosis in human gliomas
... As a member of the CLIC family, CLIC1 functions as a real chloride channel in plasma and nuclear mem- branes [19]. The distribution of intracellular CLIC1 ex- pression varies depending on the cell types, ...
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Activation of endogenous deltaF508 cystic fibrosis transmembrane conductance regulator by phosphodiesterase inhibition
... epithelial chloride channels due to mutations in the CFTR gene (reviewed in ref- erence ...purine-activated chloride channels ...residual channel ac- tivity that can be induced by stimulating the ...
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Pharmacology of skeletal muscle GABA gated chloride channels in the cockroach Periplaneta americana
... GABA-gated chloride channel in locust (Locusta migratoria) flexor tibiae ...GABA-gated chloride channels (Cull-Candy and Miledi, 1981; Cull-Candy, ...GABA-gated chloride channel, ...
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