chloroquine-resistant (CQR)
Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine
... of chloroquine-resistant parasites circulat- ing in children four years after the change in policy for the treatment of uncomplicated malaria from CQ to ...of chloroquine in the general population by ...
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Phenylurenyl benzamide analogues as a new antimalarial chemotype that potently kill chloroquine resistant parasite
... The growing resistance against current anti-malarial drugs represents a major health challenge, thus necessitating the development of new chemotypes targeting the malaria parasite at different stages of development. We ...
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Return of chloroquine sensitive Plasmodium falciparum parasites and emergence of chloroquine resistant Plasmodium vivax in Ethiopia
... The finding of this study does not support a previous study conducted in Ethiopia that reported a 100% fre- quency of the pfcrt T76 mutation, and an 81% frequency of the mutation pfmdr1 Y86 in P. falciparum [41] . How- ...
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Interaction between rifampicin, amodiaquine and artemether in mice infected with chloroquine resistant Plasmodium berghei
... Rifampicin is an antitubercular drug with potent anti- malarial activity against Plasmodium vivax in humans [21], Plasmodium chabaudi in rodents and chloroquine resistant P. falciparum in vitro [22]. ...
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Effective treatment with a tetrandrine/chloroquine combination for chloroquine resistant falciparum malaria in Aotus monkeys
... of chloroquine (CQ)-resistant fal- ciparum malaria has evoked a search for new drugs ef- fective against this drug-resistant ...drug resistant parasite with the use of racemic verapamil ...
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Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
... (CQ resistant) isolates ...for resistant vivax cases in a study in Myanmar ...CQ resistant vivax was relatively rare (only 20%) in isolates from the Thai-Myanmar border [17], but was present in 97% ...
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Chloroquine sensitivity: diminished prevalence of chloroquine resistant gene marker pfcrt 76 13 years after cessation of chloroquine use in Msambweni, Kenya
... The current study has identified an encouraging increase in the prevalence of CQS parasites in the said study area. This could be attributed to a number of fac- tors, chief among which is the reduction or absence of drug ...
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Chloroquine resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia
... In Ethiopia, there is a surveillance system for assessing the efficacy of first line drug for the treatment of P. falciparum. However, there have been no systematic studies for P. vivax. The present data confirmed the ...
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Antiplasmodial activity of chloroquine analogs against chloroquine resistant parasites, docking studies and mechanisms of drug action
... to chloroquine, in the case of ...falciparum chloroquine resistance transporter (pfcrt) gene, which alters the transport and accumulation of the drug in the digestive vacuole (DV) of the parasite ...
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Drug resistance genes: pvcrt o and pvmdr 1 polymorphism in patients from malaria endemic South Western Coastal Region of India
... falciparum. Chloroquine (CQ) is the first-line treatment for blood stage ...multidrug resistant gene ...falciparum chloroquine resistant and multi-drug resistant genes (pvcrt-o and ...
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GENETIC POLYMORPHISMS ASSOCIATED WITH CHLOROQUINE RESISTANCE AMONG PLASMODIUM FALCIPARUM ISOLATES FROM ALJUNAYNAH DISTRICT, WEST DARFUR STATE, SUDAN
... 2000, chloroquine resistance was present in almost all countries with falciparum ...of chloroquine resistant forms of falciparum malaria in Sudan was initially suggested by Omer, in central ...of ...
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Evaluation of single nucleotide polymorphisms of pvmdr1 and microsatellite genotype in Plasmodium vivax isolates from Republic of Korea military personnel
... fers chloroquine resistance to malaria provides useful information regarding the efficacy of drugs in treating ...for chloroquine-resistant ...and chloroquine-resistant phenotype in ...
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Plasmodium vivax trophozoites insensitive to chloroquine
... of chloroquine shown in this study of chloroquine sensitive ...to chloroquine resistant ...to chloroquine are; firstly an inefficient haem polymerase binding site for ...
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In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai Burmese border
... to chloroquine and lumefantrine were ...[12]. Chloroquine is believed to act by concentrating in the parasite digestive vacuole and pre- venting the conversion of toxic heme to haemozoin, lead- ing to ...
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Pharmacological Investigation of Solanum Incanum Against P. Falciparum, L. infantum, T. cruzi and T. brucei : A Role of Antioxidant Effect and Clinical overview
... The in vitro antiprotozoal and cytotoxic activity of the Solanum incanum leaves and fruit extract of Albaha region was assessed against Plasmodium falciparum (chloroquine resistant K1 strain), Leishmania ...
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Synthesis of 1-Aryloxy-2-hydroxy-3-substituted Aminocyclohexane and its Analogues for Possible Antimalarial Activity
... of Chloroquine-resistant strains of Plasmodium falciparum has dramatically reduced the Chemotherapeutic ...against Chloroquine-sensitive strain of Plasmodium falciparum invitro and ...
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PHYTO-PHARMACOLOGICAL PROFILE OF AILANTHUS EXCELSA
... drug resistant strain of Plasmodium falciparum and in vivo against Plasmodium berghei in ...for chloroquine, the toxicity was found to be very high 26 ...against chloroquine-resistant and ...
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Synthesis, Antimalarial Activity Evaluation and Drug likeness Study of Some New Quinoline-Lawsone Hybrids
... both chloroquine sensitive (RKL-2) and chloroquine resistant (RKL-9) strains of Plasmodium falciparum which was considerably less as compared to the standard drug, ...against resistant strain ...
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Indian Anti Malaria OMARIA Is Effective Against African Drug Resistant P falciparum Field Isolates and Laboratory Strains; without Toxicity
... extracts at Franceville, Gabon), we found that, OMARIA is highly selectively active against P. falciparum CQ resistant and CQ sensitive strains. This activity is consis- tent with previous data observed in Cuba ...
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A Multiplex Ligase Detection Reaction Fluorescent Microsphere Assay for Simultaneous Detection of Single Nucleotide Polymorphisms Associated with Plasmodium falciparum Drug Resistance
... Incomplete malaria control efforts have resulted in a worldwide increase in resistance to drugs used to treat the disease. A complex array of mutations underlying antimalarial drug resistance complicates efficient ...
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