chloroquine-sensitive (CQS)
In Vivo Anti-Malarial Activity of Heracleum persicum Fruit Extract, in Combination with Chloroquine against Chloroquine–Sensitive Strain of Plasmodium berghei
... and chloroquine individually against chloroquine sensitive ...for chloroquine and two control group (positive and negative) were considered for determination of ...and chloroquine also ...
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Selection for chloroquine sensitive Plasmodium falciparum by wild Anopheles arabiensis in Southern Zambia
... of chloroquine-sensitive malaria parasites following withdrawal of drug use, as observed initially in Hainan Province of China [50] and subsequently Malawi [23,24] and other areas, including the site of the ...
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Reemergence of chloroquine sensitive pfcrt K76 Plasmodium falciparum genotype in southeastern Cameroon
... In the present study, a significant increase in the pro- portion of parasites carrying the wild-type pfcrt K76 hap- lotype was observed in Messok, but the proportion of mutant and mixed alleles was still relatively high ...
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Antiplasmodial activity of methanol leaf extract of Salacia senegalensis Lam (Dc) in Albino Mice infected with chloroquine-sensitive Plasmodium berghei berghei (NK65)
... with chloroquine-sensitive Plasmodium berghei berghei (NK65) in order to justify or otherwise its use as antimalarial remedy in Nigeria folk ...of chloroquine -which had percentage suppression of ...
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Antimalarial Activity of Otostegia integrefolia Leaf Extracts against Chloroquine Sensitive Strain of Plasmodium berghei in Mic
... In the attempt to search for new plant based source of antimalarial drugs, the present study aimed at testing crude extracts from the leaves of Otostegia integrefolia against chloroquine (CQ) sensitive ...
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Return of chloroquine sensitive Plasmodium falciparum parasites and emergence of chloroquine resistant Plasmodium vivax in Ethiopia
... were sensitive to ...were sensitive to ...carried sensitive alleles, whereas the investigated F1076 (Phe1076Leu) carried no drug resistant mutants Table ...
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In vitro anti malarial efficacy of chalcones: cytotoxicity profile, mechanism of action and their effect on erythrocytes
... antiplasmodial activity with promising outcomes [17, 18]. Although several mechanisms have been postulated for various chalcones [15, 19–22], the exact mode of action still remains unclear. Besides, these chalcones are ...
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Synthesis, Antimalarial Activity Evaluation and Drug likeness Study of Some New Quinoline-Lawsone Hybrids
... both chloroquine sensitive (RKL-2) and chloroquine resistant (RKL-9) strains of Plasmodium falciparum which was considerably less as compared to the standard drug, ...against sensitive strain ...
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Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents
... against chloroquine-sensitive malaria parasite Plasmodium falciparum (3D7) and antimicrobial activity against Gram positive bacteria ...than chloroquine and clotrimazole, the standard ...
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Prevalence of Plasmodium falciparum anti malarial resistance associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to introduction of artemisinin combination therapy
... for chloroquine resistance was most prevalent in this study and was significantly as- sociated with the pfmdr1 -YYNY ...of chloroquine sensitive ...where chloroquine use was ...
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PHYTO-PHARMACOLOGICAL PROFILE OF AILANTHUS EXCELSA
... for chloroquine, the toxicity was found to be very high 26 ...against chloroquine-resistant and chloroquine sensitive strains of Plasmodium falciparum and Plasmodium vinckei petteri in ...
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In vitro and in vivo anti malarial activity of Boerhavia elegans and Solanum surattense
... In vitro activity of 10 plant extracts against CQ-sensitive (CY27) and -resistant (K1) P. falciparum strains are sum- marized in Table 2. Of 10 extracts tested, three showed significant anti-plasmodial activity at ...
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Synthesis of 1-Aryloxy-2-hydroxy-3-substituted Aminocyclohexane and its Analogues for Possible Antimalarial Activity
... of Chloroquine-resistant strains of Plasmodium falciparum has dramatically reduced the Chemotherapeutic ...against Chloroquine-sensitive strain of Plasmodium falciparum invitro and ...
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IN VIVO ANTIMALARIAL ACTICITY OF METHANOLIC EXTRACT OF YOUNG FRONDS OF PTERIDIUM AQUILINUM L. KUHN IN MICE INFECTED WITH PLASMODIUM BERGHEI
... using chloroquine sensitive plasmodium berghei infection in mice, with a view to finding scientific evidence for the use of this plant as traditional remedy for malaria ...
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Lack of significant recovery of chloroquine sensitivity in Plasmodium falciparum parasites following discontinuance of chloroquine use in Papua New Guinea
... of chloroquine-selecting pressure poten- tially interferes the recovery of chloroquine-sensitive ...where chloroquine was still widely used even after the introduction of ACT, ...vivax. ...
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In vivo study of Plasmodium falciparum chloroquine susceptibility in three departments of Haiti
... therapy. As chloroquine is inexpensive and commonly used in Haiti this study has important implications. As stated by the World Health Organization [10], high para- sitaemia is a risk factor for death from ...
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... to chloroquine in ...drug, chloroquine appears to lose its importance in most parts of the world, this inexpensive, rapid acting, well tolerated antimalarial may be still used with the same efficacy by ...
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En route to the ‘elimination’ of genotypic chloroquine resistance in Western and Southern Zambia, 14 years after chloroquine withdrawal
... These results mirror those observed in Northern Zam- bia, Malawi and Kenya [21, 34–36]. In Zambia, while not linear, there has been a general reduction in the preva- lence of the chloroquine resistance genotypes ...
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Molecular surveillance of Plasmodium falciparum drug resistance in the Republic of Congo: four and nine years after the introduction of artemisinin based combination therapy
... of chloroquine‑resistant haplotype (CVIET) from 100% in 2005, 1 year before the introduction and implementation of ACT in 2006, to 98% in 2010 to 71% in 2015 was ...
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Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology
... As mentioned, until recently the CQR vs CQS status of parasite isolates has often been assigned based on the presence of the key PfCRT K76T mutation alone [4]. In many cases however, these assignments are made ...
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