cholesterol acyltransferase
Two different allelic mutations in the lecithin cholesterol acyltransferase gene associated with the fish eye syndrome Lecithin cholesterol acyltransferase (Thr123 Ile) and lecithin cholesterol acyltransferase (Thr347 Met)
... (HDL) cholesterol was reduced at ...plasma cholesterol esterification rate was slightly reduced at 51 nmol/ml per h (control subjects: 61-106 nmol/ml per h), whereas lecithin-cholesterol ...
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Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: structure of low and high density lipoproteins as revealed by electron microscopy
... The low density lipoproteins (LDL) of d 1.019-1.063 g/ml of patients with familial lecithin: cholesterol acyltransferase (LCAT) deficiency show marked heterogeneity when viewed with the electron microscope. ...
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Pre-Clinical Development Of Aav Mediated Gene Therapy For Familial Lecithin Cholesterol Acyltransferase Deficiency
... lecithin cholesterol acyltransferase (LCAT) deficiency (FLD), is a rare monogenic disease, characterized by abnormal lipid profile, corneal opacities, anemia and renal disease which progresses to renal ...% ...
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Radioimmunoassay of human plasma lecithin cholesterol acyltransferase
... A sensitive and precise competitive-displacement double-antibody radioimmunoassay was developed for the human plasma enzyme lecithin-cholesterol acyltransferase (LCAT; Ec 2.3 1.43). The ability of plasma ...
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Expression of human lecithin cholesterol acyltransferase in transgenic mice Effect of human apolipoprotein AI and human apolipoprotein all on plasma lipoprotein cholesterol metabolism
... Human (Hu) lecithin-cholesterol acyltransferase (LCAT) is a key enzyme in the plasma metabolism of cholesterol. To assess the effects of increased plasma levels of LCAT, four lines of transgenic mice ...
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Original Article Advanced membranous nephropathy-like lesion in a Chinese patient with familial lecithin-cholesterol acyltransferase deficiency
... Lecithin-cholesterol acyltransferase (LCAT) is a key enzyme for the esterification of cholesterol in circulating plasma lipoproteins that pro- motes the maturation of discoidal pre-high- density ...
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Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: physical and chemical studies of low and high density lipoproteins
... lecithin: cholesterol acyltransferase (LCAT) deficiency have been characterized by gel filtration, analytical ultracentrifugation, and gel electrophoresis, and their relative content of lipid and protein ...
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Regulation of acylcoenzyme A Cholesterol acyltransferase and 3 hydroxy 3 methylglutaryl coenzyme A reductase activity by lipoproteins in the intestine of parabiont rats
... intestinal cholesterol synthesis (3- hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase activity) and esterification (acylcoenzyme A/cholesterol acyltransferase [ACAT] activity) by lipoproteins ...
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A frameshift mutation in the human apolipoprotein A I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol acyltransferase deficiency, and corneal opacities
... HDL cholesterol but not of coronary artery disease, thus clinically resembling fish eye ...lecithin: cholesterol acyltransferase (LCAT) activity in plasma led to sequence analysis of the genes for ...
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Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits In vivo apolipoprotein A I catabolism is delayed in a gene dose dependent manner
... Lecithin cholesterol acyltransferase (LCAT) is an enzyme involved in the intravascular metabolism of high density lipoproteins ...HDL cholesterol concentrations (mg/dl), respectively, were 162+/-18 ...
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Genetic and phenotypic heterogeneity in familial lecithin: cholesterol acyltransferase (LCAT) deficiency Six newly identified defective alleles further contribute to the structural heterogeneity in this disease
... lecithin:cholesterol acyltransferase (LCAT) deficiency in six probands from five families originating from four different countries was confirmed by the absence or near absence of LCAT ...unesterified ...
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Association of Lecithin Cholesterol Acyltransferase rs5923 Polymorphism in Iranian Individuals with Extremely Low High-Density Lipoprotein Cholesterol: Tehran Lipid and Glucose Study
... lipoprotein cholesterol (HDL-C) is one of the important heritable risk factors for cardiovascular disease and is a target for therapeutic ...lecithin cholesterol acyltransferase (LCAT) gene ...
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Markedly accelerated catabolism of apolipoprotein A II (ApoA II) and high density lipoproteins containing ApoA II in classic lecithin: cholesterol acyltransferase deficiency and fish eye disease
... Classic complete lecithin:cholesterol acyltransferase LCAT deficiency and Fish-eye disease partial LCAT deficiency are genetic syndromes associated with markedly decreased plasma levels [r] ...
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Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia
... To explore the structural and dynamic properties of WT and LCAT mutations, we carried out molecular in-silico dynamic simulations for LCAT protein in water. The p.M404 V mutation is located adjacent to the ...
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Fish eye syndrome: a molecular defect in the lecithin cholesterol acyltransferase (LCAT) gene associated with normal alpha LCAT specific activity Implications for classification and prognosis
... specific activities assayed using an HDL-like proteoliposome substrate were 12.7-25.7 nmol/micrograms (19.5 +/- 1.8 in controls). In addition, significant residual cholesterol esterification was present in ...
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The role of lecithin: cholesterol acyltransferase for lipoprotein (a) assembly Structural integrity of low density lipoproteins is a prerequisite for Lp(a) formation in human plasma
... Normal LDL, LDL from a nomolipemic donor, in the absence or the presence of detergent Tween20 or NaCl; GS/LDL density particles, LDL floating particles from the homozygous LCAT-D individ[r] ...
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Pioglitazone prevents cholesterol gallstone formation through the regulation of cholesterol homeostasis in guinea pigs with a lithogenic diet
... A cholesterol acyltransferase 2 (ACAT2), and subsequently transported in the chylomi- crons circulating then reaches the liver for biliary secretion [9, ...hepatic cholesterol biosynthesis while ...
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Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
... Acyl-CoA cholesterol acyltransferase; ACC1: acetyl-CoA carboxylase; ASBT: apical sodium-dependent bile acid transporter; BA: bile acids; BMI: body mass index; CAMK2: calcium–calmodulin dependent kinase 2; ...
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Original Article Effects of leptin on acyl-CoA: cholesterol O-acyltransferase-1 expression and activity during foam cell differentiation in human mononuclear THP-1 cells
... Abstract: The mechanism of atherosclerosis is not yet entirely clear. The transformation of mononuclear cells into macrophages has been shown to be one of early events leading to atherosclerosis. This study was to detect ...
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Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature
... Acyl-CoA cholesterol acyltransferase (ACAT) inhibitors ACAT (also known as SOAT, see footnote on nomencla- ture in Table 1) is a key enzyme catalyzing the esterifica- tion of ...
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