Cholesterol biosynthesis
Cholesterol biosynthesis pathway as a novel mechanism of resistance to estrogen deprivation in estrogen receptor positive breast cancer
... the cholesterol biosynthesis pathway (Additional file 2: Figure S1) [37–40] was upregulated ex- clusively in all LTED derivatives that retained expression of ER both in 2D and 3D culture (Table ...the ...
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Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes
... adipocyte cholesterol content and fat cell size and triglyceride content and bigger the fat cell, the more cholesterol it has been shown to contain ...novo cholesterol synthesis in adi- pose tissue ...
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Impaired Cholesterol Biosynthesis in a Neuronal Cell Line Persistently Infected with Measles Virus
... involved cholesterol biosynthesis, we chose to focus on the cholesterol biosynthesis pathway in ...for cholesterol biosynthesis in the regulation of MV infection ...
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Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells
... The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as ...
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Intracellular cholesterol biosynthesis in enchondroma and chondrosarcoma
... Intracellular cholesterol biosynthesis plays a crucial role in chondrocyte ...intracellular cholesterol level is low, SCAP cleaves and activates the transcription factors known as SREBPs ...for ...
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A molecular defect in hepatic cholesterol biosynthesis in sitosterolemia with xanthomatosis
... transplantation was identified. Accelerated atherosclerosis, unrestricted intestinal sterol absorption, increased plasma and tissue plant sterol concentrations, and low cholesterol synthesis characterize this ...
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Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes
... largest cholesterol pool. In AT, nearly all cholesterol (>95%) exists as free, non- esterified form and resides in the plasma membrane or at the cytosolic interface of lipid droplets ...esterified ...
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EFFECTS OF TRIPARANOL (MER 29) ON CHOLESTEROL BIOSYNTHESIS AND ON BLOOD STEROL LEVELS IN MAN
... Comparison of specific radioactivities of serumfree desmosterol and serum free cholesterol 4 hours after intravenous injection of 2-C'4-mevalonic acid in patients under treatment with ME[r] ...
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Investigation of the molecular mechanisms of the inhibition of hepatic fatty acid and cholesterol biosynthesis by hypolipidaemic agents
... lipid biosynthesis, especially fatty acid synthesis in liver (Adams et d , ...hepatic cholesterol synthesis accompanied by 50% and 90% inhibition o f HMG-CoA reductase, ...
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Effects of Early Cholesterol Intake on Cholesterol Biosynthesis and Plasma Lipids Among Infants Until 18 Months of Age
... the cholesterol supplementation brought the FSR of the MCF-fed infants closer to the physiologic range seen among breastfed ...excess cholesterol accumulation during high cholesterol intakes or, ...
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Cholesterol biosynthesis inhibitor RO 48-8071 reduces progesterone receptor expression and inhibits progestin-dependent stem cell-like cell growth in hormone-dependent human breast cancer cells
... Abstract: Clinical trials and studies have shown that postmenopausal women undergoing com- bination hormone replacement therapy containing estrogen and progestin have an increased risk of breast cancer compared with ...
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Reproducing abnormal cholesterol biosynthesis as seen in the Smith Lemli Opitz syndrome by inhibiting the conversion of 7 dehydrocholesterol to cholesterol in rats
... After 2 wk of BM 15.766 treatment, HMG-CoA reductase activities and steady state mRNA levels were increased indicating up-regulation of early steps of the cholesterol biosynthetic pathwa[r] ...
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CHOLESTEROL BIOSYNTHESIS STUDIES RELATED TO THE METABOLIC ROLE OF SQUALENE
... Oral administration of hydrocarbon fraction containing squalene-T in the human The specific activity of plasma-free cholesterol following oral administration of the hydrocarbon fraction [r] ...
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Role of Low Density Lipoprotein Receptor as a Potential Suppressor of Growth and Survival of Colorectal Cancer Cells
... of cholesterol for membrane biogenesis and assembly of lipid rafts for facilitating cellular growth ...and cholesterol pathway by SREBPs is critical for growth and survival of cancer ...and ...
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Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing
... and cholesterol biosynthesis that (a) associates with the rate of wound healing and (b) is under strong genetic control in trans by the transcription factor Runx2 located on mouse chromosome ...in ...
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Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho GDI signalling and mitochondrial metabolism
... Figure S2: Correlations of proteomics data sets in MCF7 and T47D A-B Twenty-five proteins involved in the mevalonate pathway and cholesterol biosynthesis, were found to be up-regulated f[r] ...
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PPARγ regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1
... novo cholesterol biosynthesis (13) and obtain a majority of their sterols from lipoproteins in the circulation ...of cholesterol, scavenger receptors could be essential for adipocyte uptake of the ...
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Chemical Synthesis of Ring C oxygenated Derivatives of Cholesterol and their Inhibition of Sterol Biosynthesis
... of cholesterol and sterol intermediates in cholesterol biosynthesis have been found to be potent inhibitors of sterol biosynthesis in animal cell ...of cholesterol biosynthesis ...
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Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo.
... inhibits cholesterol synthesis, the proteomic analysis suggested that cholesterol biosynthesis was upregulated (Figure 6B and quantification in Figure S1G), with most of the enzymes driving ...
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Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells
... in cholesterol biosynthetic pathway (Figure ...of cholesterol biosynthesis and other cholesterol- associated pathways could positively regulate CD-20 expression and its antibody-mediated ...
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