Cholesterol efflux capacity
High-density lipoprotein cholesterol efflux capacity is inversely associated with cardiovascular risk: a systematic review and meta-analysis
... reverse cholesterol transport (RCT) as well as anti-inflammatory, endothelial and vascular functions ...accept cholesterol derived from artery-wall macrophages and mediate delivery to the liver for ...
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Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9
... affects cholesterol ef- flux capacity of serum, macrophage foam cell formation was induced and cells were treated with mouse serum as previously described ...fluorescent cholesterol mimic present in ...
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Increased maternal and fetal cholesterol efflux capacity and placental cyp27a1 expression in pre eclampsia
... increased cholesterol efflux capacity only in late-onset ...the capacity to protect against lipid peroxidation or have not been exposed to metabolic challenge as those with late-onset ...
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Effects of the SGLT2 inhibitor dapagliflozin on HDL cholesterol, particle size, and cholesterol efflux capacity in patients with type 2 diabetes: a randomized placebo-controlled trial
... CEC: cholesterol efflux capacity; CerVD: cerebrovascular disease; CETP: cholesteryl ester transfer protein; CKD: chronic kidney disease; DEXA: dual-energy X-ray analysis; DPP-4i: dipeptydil peptidase ...
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The negative effect of ANGPTL8 on HDL-mediated cholesterol efflux capacity
... in fat and liver (RIFL) and hepatocellular carcinoma- associated protein (TD26), was found to be a novel player in lipid metabolism [12]. ANGPTL8, together with ANGPTL3 and ANGPTL4, could regulate triglyc- eride ...
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Low cholesterol efflux capacity and abnormal lipoprotein particles in youth with type 1 diabetes: a case control study
... LDL cholesterol and low HDL ...HDL cholesterol, measured with traditional assays, com- pared to healthy subjects, which seems to suggest that HDL cholesterol, which is typically protective against ...
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HDL cholesterol efflux capacity in rheumatoid arthritis patients: contributing factors and relationship with subclinical atherosclerosis
... assessing cholesterol efflux in vitro, most research done in population-based cohorts has been carried out using the same assay as the one described in our ...mediate cholesterol efflux from ...
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Proteomic alterations of HDL in youth with type 1 diabetes and their associations with glycemic control: a case–control study
... In summary, we found altered protein composition of HDL in youth with T1DM compared to HC by combin- ing size-exclusion chromatography-based HDL puri- fication and SWATH-MS-based label-free proteomic quantitation. The ...
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USF1 deficiency alleviates inflammation, enhances cholesterol efflux and prevents cholesterol accumulation in macrophages
... enhances cholesterol efflux, lowers macrophage inflammatory sta- tus, and reduces cholesterol accumulation, supports and expands our previous findings, in which we showed that Usf1 deficiency results ...
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Plasminogen promotes cholesterol efflux by the ABCA1 pathway
... Cholesterol efflux capacity (CEC) — the ability of human serum depleted of lipoproteins containing apolipoprotein B (APOB) to promote cholesterol efflux from macrophages — can vary ...
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Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein
... excess cholesterol from macrophages, TICE may play no role in the pathogenesis of ...with cholesterol-loaded macrophages, the radiolabled cholesterol appeared undeterred in the intestinal lumen ...
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Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages
... to efflux cholesterol to apoA-I; resveratrol was included as a putative positive control in these experiments, as this molecule is known to exert hormetic and cell-specific effects ...
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Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
... to cholesterol traversing the lymph ...high cholesterol may promote cholesterol accumulation in the artery wall, as well as in tissues like skin that are affected in ...when cholesterol ...
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Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes
... We have also shown that the pheno- type in ABCA1 heterozygotes is age modulated. Beginning at 20 years of age, there is a small but definite increase in HDL-C with advancing age that is obviously absent in the ...
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Caveolin 1 reduces HIV 1 infectivity by restoration of HIV Nef mediated impairment of cholesterol efflux by apoA I
... and cholesterol subsequently counters Nef induced impair- ment of cholesterol efflux by ...for cholesterol efflux [4] over-expression of Cav-1 may induce the forma- tion of more ...
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Original Article Adiponectin upregulates ABCA1 expression through liver X receptor alpha signaling pathway in RAW 264.7 macrophages
... HPLC analysis was conducted as previously described [13]. After washed with PBS for three times, cells were removed by scraping with a rubber and sonicated using an ultrasonic pro- cessor for 10 min. A 0.1 ml aliquot ...
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The role of cholesterol efflux in regulating the fertilization potential of mammalian spermatozoa
... for cholesterol removal from the sperm plasma membrane (10, ...membrane cholesterol/phospho- lipid ratios ...other cholesterol acceptors like HDL and β -cyclodextrins effectively support capacitation ...
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Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
... transporter/cholesterol efflux regulatory protein (CERP); ACAT : Acyl-CoA cholesterol acyltransferase; ACC1: acetyl-CoA carboxylase; ASBT: apical sodium-dependent bile acid transporter; BA: bile ...
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Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux
... lipid efflux have been stud- ied extensively in ...and cholesterol efflux in macrophages ...and cholesterol efflux in T cells by ...free cholesterol efflux, which contrib- ...
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Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature
... The striking age-dependence of disease is not under- stood. For many pathogens, infections are acquired in early childhood and remain stable, but for others there is a clear age-related increase in seropositivity rates ...
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