CHOLESTEROL ESTER TRANSFER PROTEIN (CETP)
The levels of plasma low density lipoprotein are independent of cholesterol ester transfer protein in fish-oil fed F1B hamsters
... * Corresponding author Abstract Background: Cholesterol ester transfer protein (CETP) plays a major role in regulating the levels of LDL- and HDL-cholesterol. We previously observed a ...
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Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease
... Cholesteryl ester; CETP: Cholesterol ester transfer protein; CI: Confidence interval; CK-MB: Creatine kinase-MB; cTnI: Cardiac troponin I; CVD: Cerebral vascular disease; ELISA: ...
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Ciprofibrate increases cholesteryl ester transfer protein gene expression and the indirect reverse cholesterol transport to the liver
... Cholesteryl ester transfer protein (CETP) promotes the transfer of cholesteryl esters (CE) from high density lipo- protein (HDL) to the apoB-containing lipoprotein parti- cles, which ...
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Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI
... cholesteryl ester transfer protein (CETP) on cell cholesterol efflux, when these proteins are expressed in transgenic ...for cholesterol released in 4 h from Fu5AH donor cells to 5% ...
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Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women
... cholesteryl ester transfer protein, and high-density lipoprotein cholesterol The association between alcohol intake and higher HDL-C levels is well ...key protein in HDL-C ...lecithin ...
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An interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A I genes in transgenic mice results in a profound CETP mediated depression of high density lipoprotein cholesterol levels
... cholesteryl ester transfer protein (CETP) minigene driven by the mouse metallothionein-I gene ...HDL cholesterol levels, particle size distribution, and metabolism in animals with mouse and ...
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Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial
... The ILLUMINATE study 3 was the fi rst clinical trial to address the eff ect of lowering CETP on cardiovascular disease outcome. In this study, torcetrapib, a CETP inhibitor that reduced LDL cholesterol levels by ...
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Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice Dependence on natural flanking sequences
... restricted. There was a marked (4-10-fold) induction of liver CETP mRNA in response to a high fat, high cholesterol diet. The increase in hepatic CETP mRNA was accompanied by a fivefold increase in transcription ...
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Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure
... lower CETP concentration. The involvement of CETP in atherosclerosis, whether this protein is beneficial or pro-atherogenic, is largely controversial. CETP inhibi- tors, that pronouncedly increase anti-atherogenic ...
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Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol
... CETP deficiency, reflecting two prevalent mutations (D442G and Intl4 A), is the first example of a genetic deficiency state which is sufficiently common to explain a significant fraction[r] ...
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Forhidrol, a bioactive fraction of Phaleria macrocarpa (Scheff.) Boerl., increases reverse cholesterol transport pathway by down-regulation of cholesteryl ester transfer protein activity
... PPARs are transcription factors that play crucial roles in lipid and lipoprotein metabolism, which consists of three proteins including alpha, beta/delta and gamma. 54 Considerable evidences indicated that stimulation of ...
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Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib
... LDL cholesterol, in contrast to the LDL lowering of up to 40% seen with the other ...CETP’s transfer function seen with the other agents, dalcetrapib is a weaker ...the transfer of CE from HDL 3 to ...
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Inhibition of cholesteryl ester transfer protein activity by monoclonal antibody Effects on cholesteryl ester formation and neutral lipid mass transfer in human plasma
... CE transfer, HDL and LDL exhibited cholesterol esterification activity, whereas VLDL did ...mass transfer in incubated human plasma, (b) the rate of CE formation in plasma is not regulated by CE ...
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The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice
... free cholesterol accumulation in the is- lets; 3) reduce the expression of the genes which participate in beta cell proliferation and differentiation, resulting in fewer and smaller islet number and size; 4) ...
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Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition
... of cholesterol in all HDL subclasses, the triglycer- ide composition, ...circulating cholesterol and ...LDL cholesterol and apolipoprotein B ...
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Cholesteryl ester transfer-protein modulator and inhibitors and their potential for the treatment of cardiovascular diseases
... major transfer functions of plasma CETP by inducing a nonpro- ductive complex between the transfer protein and ...H-labeled cholesterol- containing autogous macrophages, despite increasing ...
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Cholesteryl ester transfer protein: A potential target for the treatment of coronary artery disease
... this protein. At present, the fibrates are used to increase HDL cholesterol levels and their beneÞ ts have been demonstrated in a large clinical ...HDL cholesterol have been reported with the CETP ...
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PHARMACOGENOMIC STUDIES OF CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) GENOTYPES IN SUSPECTED CAD PATIENTS
... Cholesteryl ester transfer protein (CETP) gene polymorphism rs708272 (Taq1B) with cardiovascular diseases, since variations in the CETP gene alters the HDL-C ...other cholesterol lowering ...
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I405V and -629C/A Polymorphisms of the Cholesteryl Ester Transfer Protein Gene in Patients with Coronary Artery Disease
... cellular cholesterol removal could be involved in the apparent cardio protective role of CETP gene variation that relates to higher expression of this lipid transfer protein ...lipid transfer ...
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Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene
... cholesteryl ester transfer protein (CETP) facilitates the transfer of cholesteryl ester from HDL to triglyceride-rich ...HDL cholesterol levels, but CETP may also promote reverse ...
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