Cholesterol synthesis
Malformation syndromes due to inborn errors of cholesterol synthesis
... some cholesterol precursors are biological- ly active, abnormally low or high concentrations of specific sterols may have functional ...for cholesterol, desmosterol likely has inde- pendent ...bioactive ...
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EFFECT OF CHOLESTEROL SYNTHESIS INHIBITION IN NORMOCHOLESTEREMIC YOUNG MEN
... The reduction in fecal sterol output may be interpreted in three ways: 1 It may represent no change in endogenous cholesterol synthesis with an actual retention of cholesterol in the tis[r] ...
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SERUM SQUALENE AND NON-CHOLESTEROL STEROLS RELATED TO CHOLESTEROL SYNTHESIS AND ABSORPTION IN TYPE 2 DIABETES
... Since cholesterol synthesis is markedly high in obese subjects, the study population may be heterogeneous, the lean ones mimicking normal subjects, resulting in variation of squalene and surrogate markers ...
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Plasma mevalonate as a measure of cholesterol synthesis in man
... with cholesterol synthesis rates that were measured by the sterol balance method: plasma MVA concentrations were directly related to the rate of whole body cholesterol synthesis (r = ...of ...
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Cholesterol synthesis is required for cutaneous barrier function in mice
... lipid synthesis which is associated with the rapid restoration of stratum corneum lipids and barrier ...cutaneous cholesterol synthesis in the barrier ...of cholesterol to the stratum corneum ...
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MicroRNA 33a regulates cholesterol synthesis and cholesterol efflux related genes in osteoarthritic chondrocytes
... Furthermore, we have also previously shown that the induction of SREBP-2 by TGF-β1 in human chondro- cytes is mediated through the PI3K/Akt pathway [11]. To show whether the PI3K/Akt pathway is directly or indirectly ...
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The mechanisms of and the interrelationship between bile acid and chylomicron mediated regulation of hepatic cholesterol synthesis in the liver of the rat
... Hepatic cholesterol synthesis is controlled by both the size of the bile acid pool in the enterohepatic circulation and by the amount of cholesterol reaching the liver carried in chylomicron ...
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Patients with Abdominal Aortic Aneurysm Demonstrate Higher Levels of Non-cholesterol Sterol Markers of Endogenous Cholesterol Synthesis
... of cholesterol absorption – campesterol and sitosterol (P = ...hand, cholesterol synthesis markers – lanosterol, desmosterol and lathosterol – were significantly higher in the AAA patient group ...
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The relation between cholesterol absorption and cholesterol synthesis in the baboon
... total cholesterol production rates, cholesterol absorption, and total endogenous cholesterol synthesis have been measured in these animals by a double isotope technique in which the animals ...
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Cholesterol synthesis in the intestine of man: regional differences and control mechanisms
... endogenous synthesis principally in the liver and gastrointestinal ...while cholesterol feeding for 7 days did not alter the rate of cholesterol synthesis (75 ±12 mµmoles/g per 2 ...to ...
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FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS IN MAN
... Some indication of the reproducibility of the method of measurement of cholesterol synthesis in human liver is given by the two studies Patients 1 and 2 in which duplicate samples of liv[r] ...
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CHOLESTEROL SYNTHESIS FROM C14—ACETATE IN MAN
... However, there is no information concerning either the dynamic aspects of this process or the rate of disappearance of labeled cholesterol after its synthesis from acetate in man.3 In or[r] ...
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STUDIES ON THE SITE OF THE FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS
... Each of the reactions prior to the synthesis of mevalonate is involved in the production of other end products as well as of cholesterol Figure 2; in contrast, the conversion of /3-hydro[r] ...
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Metabolism of adrenal cholesterol in man: II In vitro studies including a comparison of adrenal cholesterol synthesis with the synthesis of the glucocorticosteroid hormones
... the synthesis of adrenal cholesterol may normally be small in the zona “fasciculata,” particularly when compared with the synthesis of the glucocorticosteroid hormones, that it is several times ...
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Cholesterol synthesis in the squirrel monkey: relative rates of synthesis in various tissues and mechanisms of control
... of synthesis in 10 other tissues tested were considerably lower than these found in the gastrointestinal ...organ synthesis were calculated, three tissues, ...
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CHOLESTEROL CONCENTRATION AND CHOLESTEROL SYNTHESIS IN AORTAS OF RATS WITH RENAL HYPERTENSION
... The results suggest that the difference between aortic cholesterol concentrations in normotensive and hypertensive rats is dependent on local effects of the high blood pressure on the ao[r] ...
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EFFECT OF ENDOGENOUS AND EXOGENOUS CHOLESTEROL ON THE FEEDBACK CONTROL OF CHOLESTEROL SYNTHESIS
... In contrast to the case of the cholesterol-fed birds, the hepatic cholesterol concentrations in the stilbestrol-treated chickens clearly did not parallel the serum cholesterol levels, an[r] ...
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Cholesterol synthesis by the gastrointestinal tract: localization and mechanisms of control
... In segments proximal to the infusion point the synthesis of digitonin precipitable sterols became elevated to levels characteristic of the synthetic activitv of these segments in animals[r] ...
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Desmosterolosis: an illustration of diagnostic ambiguity of cholesterol synthesis disorders
... Desmosterolosis is an autosomal recessive disorder of cholesterol biosynthesis caused by biallelic mutations of DHCR24 (homozygous or compound heterozygous), which encodes 3- β -hydroxysterol Δ -24-reductase. We ...
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Effects of ezetimibe on cholesterol metabolism in HIV infected patients with protease inhibitor associated dyslipidemia: a single arm intervention trial
... in cholesterol synthesis markers, which were in the range of the changes reported in non-HIV dyslipidemic subjects [15,17,18], sug- gesting that PI-containing ART has no major effect on cholesterol ...
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