choline acetyltransferase (EC 2.3.1.6.)
Co-expression of GAD67 and choline acetyltransferase in neurons in the mouse spinal cord: a focus on lamina X
... Lamina X of the spinal cord is a functionally diverse area with roles in locomotion, autonomic control and processing of mechano and nociceptive information. It is also a neurochemically diverse region. However, the ...
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A Non-Canonical Role for Choline Acetyltransferase in Chromatin Organization and the Response to Beta-Amyloid
... 82-kDa choline acetyltransferase (82-kDa ChAT) protein and special AT-rich sequence binding protein 1 (SATB1) are associated with scaffolding/matrix attachment regions after neuronal cells were exposed to ...
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embryonic chicken retina neurons (synaptogenesis/neural development/acetylcholine/trophic factors)
... ABSTRACT The effect of insulin on the appearance of the enzyme choline acetyltransferase (ChoAcT; acetyl-CoA:cho- line O-acetyltransferase, EC 2.3.1.6) in embryonic chicken retina neuron[r] ...
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CHOLINE ACETYLTRANSFERASE-DEFICIENT MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS
... It would, therefore, appear that such selection schemes select for a narrow “window” of residual ChAT activity: the enzyme activity must be low enough to give resistan[r] ...
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Concordance between in vivo and postmortem measurements of cholinergic denervation in rats using PET with [18F]FEOBV and choline acetyltransferase immunochemistry
... When using only OD values restricted to the same cortical area as the [ 18 F] FEOBV DVR cluster in the dorsal left frontal cortex (see Figure 5), a significant correlation of 75% ( p = 0[r] ...
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Characterization of Human 82-kDa Choline Acetyltransferase expression in a newly developed Transgenic Mouse Model
... choline and acetyl-CoA to ACh (Blusztajn & Berse 2000). ACh is then packaged into synaptic vesicles by VAChT which is an amine/proton antiporter that is dependent on a proton gradient generated in synaptic ...
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Co-expression of GAD67 and choline acetyltransferase reveals a novel neuronal phenotype in the mouse medulla oblongata
... GABAergic and cholinergic systems play an important part in autonomic pathways. To determine the distribution of the enzymes responsible for the production of GABA and acetylcholine in areas involved in autonomic control ...
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12-11-2013 12:00 AM The role of choline acetyltransferase variants in Alzheimer's disease models
... Figure 3.4 Expression of 82-kDa ChAT and R560H 82-kDa ChAT alter BACE1 and BACE1 trafficking protein levels in APP/PS1 cortical neurons 35 Figure 3.5 The trafficking genes, SORT1 and [r] ...
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Bifurcation Analysis of a Coupled Acetylcholinesterase/Choline Acetyltransferase Enzymes Neurocycle
... A diffusion-reaction, two-compartment model was used to explore the bifurcation and chaotic behavior of acetylcholi- nesterase (AChE) and cholineacetyltransferase (ChAT) coupled enzymes system. The effects of hydrogen ...
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Motor neuron derivation from human embryonic and induced pluripotent stem cells: experimental approaches and clinical perspectives
... ALS: Amyotrophic lateral sclerosis; BDNF: Brain-derived neurotrophic factor; BMP: Bone morphogen protein; ChAT: Choline acetyltransferase; CNS: Central nervous system; EB: Embryoid body;[r] ...
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The absence of retinal input disrupts the development of cholinergic brainstem projections in the mouse dorsal lateral geniculate nucleus
... To address this, we examined another major nonret- inal projection to dLGN, the ascending cholinergic input from the brainstem. Estimates reveal that about 25% of all synapses in dLGN arise from brainstem cholinergic ...
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The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis
... ALS: Amyotrophic lateral sclerosis; BM: Bone marrow; ChAT: Choline acetyltransferase; DMSO: Dimethyl sulfoxide; FBS: Fetal bovine serum; ENS: Enteric nervous system; H&E: haematoxyli[r] ...
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Neurogenic potential of dental pulp stem cells isolated from murine incisors
... Millipore), choline acetyltransferase (ChAT; Biosensis, Thebarton, South Australia, Australia), tyrosine hydroxylase (Chemi- con) and vesicular glutamate transporter 2 (vGlut2; Synaptic Systems, Goettingen, ...
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Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
... ChAT: Choline acetyltransferase; CNS: Central nervous system; dmX: dorsal motor nucleus of the vagus nerve; ENS: Enteric nervous system; HG: Hypoglossal nucleus; LB: Lewy body; NOS1: Nitric oxide synthase ...
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A scalable solution for isolating human multipotent clinical-grade neural stem cells from ES precursors
... CHAT: Choline acetyltransferase; CNS: Central nervous system; CoMo-NSC: hNSCs purified based on colony morphology; Cxcr4: C-X- C chemokine receptor type 4; DAB: Diaminobenzidine; Dach-1: Dachshund family ...
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Pathological changes of distal motor neurons after complete spinal cord injury
... (choline acetyltransferase), VAChT (cho- line vesicle transporter), and other choline-related transport molecules such as KIF3A, KIF3B, and KAP3 were increased in the Tx3m group compared to the Naive ...
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Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders
... AD: Alzheimer ’ s disease; ChAT: Choline-acetyltransferase; DAB: 3 ′ 3- diaminobenzidine; DLB: Dementia with Lewy bodies; FFPE: Formalin-fixed paraffin-embedded; GAL-ir: Galanin immunore[r] ...
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Is aclidinium alone or combined with a LABA a rational choice for symptomatic COPD patients?
... ChAT: Choline acetyltransferase; CI: Confidence interval; COPD: Chronic obstructive pulmonary disease; CRISPLD2: Cysteine-rich secretory protein LCCL domain-containing 2; DALY: Disability adjusted life ...
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Wiring Sympathetic Neuron Subpopulations into Target-Selective Circuits for Homeostasis
... functional signature genes such as tyrosine hydroxylase and choline acetyltransferase it progressed to the characterization of the full transcriptome detected in cell bodies of postga[r] ...
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The cellular diversity of the pedunculopontine nucleus : relevance to behavior in health and aspects of Parkinson's disease
... Abbreviations Acetylcholine, ACh; Ascending reticular activating system, ARAS; Choline acetyltransferase, ChAT; Clozapine-N-oxide, CNO; Deep brain stimulation, DBS; Dementia with Lewy bo[r] ...
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