Chondrocyte apoptosis
Nitric oxide-associated chondrocyte apoptosis in trauma patients after high-energy lower extremity intra-articular fractures
... the chondrocyte and to finding alterations in chondrocyte viability in human and animal cartilage after blunt trauma ...by apoptosis (programed cell death). Apoptosis was first identified in ...
7
Original Article Does dynamic immobilization reduce chondrocyte apoptosis and disturbance to the femoral head perfusion?
... that apoptosis of chon- drocytes is the early findings in the experimen- tal models of ischemic cartilaginous epiphysis of femoral head [14, ...of chondrocyte apoptosis and apoptosis-relat- ed ...
12
Time dependence of changes of two cartilage layers in anterior cruciate ligament insertion after resection on chondrocyte apoptosis and decrease in glycosaminoglycan
... cyte apoptosis can cause imbalances in the levels of matrix metalloproteinases and their inhibitor derived from affected synovial membranes [8-10], and in proinflamma- tory responses ...affect chondrocyte ...
6
Original Article Overexpression of microRNA-149 inhibits chondrocyte apoptosis by regulating expression of Bcl-2, Bax, and p53
... that chondrocyte apoptosis is one of the major factors involving in the pathogenesis of OA ...integrity. Apoptosis and loss of chondrocyte survival would result in the failure of the articular ...
7
Quantification of Chondrocyte Apoptosis in Mechanically Impacted Articular Cartilage
... investigate chondrocyte apoptosis caused by impactions of different force levels at various culture times after the ...the chondrocyte numbers in articular cartilage is reported in studies looking at ...
111
LncRNA MCM3AP AS1 regulates miR 142 3p/HMGB1 to promote LPS induced chondrocyte apoptosis
... The Fourth Affiliated Hospital of China Medical Univer- sity Ethics Committee approved this study (No. FAHCMU20160245298, the investigation of lncRNA MCM3AP-AS1 in LPS-induced chondrocyte apoptosis). ...
7
CD95 induced osteoarthritic chondrocyte apoptosis and necrosis: dependency on p38 mitogen activated protein kinase
... of apoptosis and necrosis. (a) Morpho- logic analysis of chondrocyte apoptosis and ...cell apoptosis and necrosis quantified by flow cytome- ...distinguishes apoptosis from ...
10
miR 146a, an IL 1β responsive miRNA, induces vascular endothelial growth factor and chondrocyte apoptosis by targeting Smad4
... regulating chondrocyte differentiation by inhibiting hypertrophy and cell ...mice, chondrocyte prolif- eration is reduced, hypertrophic differentiation is accelerated, and apoptosis is increased ...
13
<p>Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model</p>
... chondrocyte apoptosis in vivo and in vitro settings, 21,22 resulted in cartilage matrix degradation and joint in fl amma- tion, thereby contributing to OA ...decreased chondrocyte viability, which was ...
10
Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis
... vitro apoptosis of chondro- cytes, as evaluated by enhanced mRNA expression of p53, increased BAX/BCL-2 ratio, activated caspase-3, and increased DNA ...Cyt-induced chondrocyte apoptosis ...the ...
13
Original Article Shikonin protects chondrocytes from interleukin-1beta-induced apoptosis by regulating PI3K/Akt signaling pathway
... Increased chondrocyte apoptosis is considered an important pathological feature of OA ...in chondrocyte apoptosis in ...subsequent apoptosis inhibition ...reduced chondrocyte ...
11
Detecting cathepsin activity in human osteoarthritis via activity based probes
... of chondrocyte apoptosis and gene regulation related to OA pathology via regula- tion of SIRT1 activity ...various chondrocyte cultures were stimulated with pro-inflammatory cytokines TNFα and IL-1β ...
14
New developments in osteoarthritis: Posttraumatic osteoarthritis: pathogenesis and pharmacological treatment options
... Chemical caspase inhibitors are available that are specifi c for individual caspases or neutralize the activity of all caspases. Such pan-caspase inhibitors would be ideally suited to be eff ective as interventions for the ...
9
Original Article Effect of quercetin on interleukin-1β-induced apoptosis of chondrocyte
... the apoptosis that inducted by IL-1β and the poten- tial mechanism may be affected by influence the expression of Bcl-2/Bax and Caspase ...The chondrocyte apoptosis model that uses 50 μg/mL IL-1β ...
7
Original Article Mefloquine inhibits chondrocytic proliferation by arresting cell cycle in G2/M phase
... induces chondrocyte apoptosis through mito- chondrial pathway [7, ...of chondrocyte proliferation inhibit formation of cartilage and reduce the strength of ...
6
Impact of storage conditions on electromechanical, histological and histochemical properties of osteochondral allografts
... on chondrocyte viability during allograft ...decrease chondrocyte apoptosis induced by traumatic compression or collagenases treat- ment [59, ...on chondrocyte viability, apoptosis and ...
12
LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
... with chondrocyte death [15, 16]. Chondrocyte apoptosis inhibition is a potential approach for the treatment of osteoarthritis ...the apoptosis of ...
5
Wnt/β catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
... uncoupled chondrocyte hypertrophy and osteoblast ...In chondrocyte survival, Wnt/  -catenin is upstream of Ihh signaling when inhibiting chondrocyte ...during chondrocyte hypertrophy and ...
13
GIT1 gene deletion delays chondrocyte differentiation and healing of tibial plateau fracture through suppressing proliferation and apoptosis of chondrocyte
... Methods: The study used 72 C57/BL6 mice. A tibial plateau fracture model was established by using mice with the same number of GIT1 gene deletions (the experimental group) and their wild-type littermates (the control ...
7
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy
... both chondrocyte hypertrophy and bone formation in the developing skeletal ...inhibit chondrocyte hypertrophy and to suppress further Ihh expression by keeping chondrocytes in a proliferating state (Lanske ...
10