Chondrocyte differentiation
GIT1 gene deletion delays chondrocyte differentiation and healing of tibial plateau fracture through suppressing proliferation and apoptosis of chondrocyte
... regulate chondrocyte pro- liferation through the activation of GIT1, which proves that GIT1 gene deletion could delay the healing process [24, ...osteoclasts differentiation, which could prove our results ...
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Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP
... Hedgehog overactivation in the context of PTHrP overexpression stimulated expression of BapX1, used as a marker for columnar chondrocytes, in vivo and in vitro. Since tibiae of PTHrP-Tg mice at the ages used in the ...
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Dlx5 regulates chondrocyte differentiation at multiple stages
... vertebrates. Chondrocyte differentiation within the cartilaginous core of these skeletal elements is tightly regulated, both spatially and ...cyte differentiation and inhibits proliferation in ...
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Lasp1 misexpression influences chondrocyte differentiation in the vertebral column
... ABSTRACT The mouse mutant wavy tail Tg(Col1a1-lacZ)304ng was created through transgene insertion and exhibits defects of the vertebral column. Homozygous mutant animals have compressed tail vertebrae and wedge-shaped ...
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Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation
... Ihh is one of the main regulators of endochondral ossification, acting on different target tissues. To understand how these tissues interpret the Ihh signal it is important to investigate the downstream transcription ...
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Uhrf1 is indispensable for normal limb growth by regulating chondrocyte differentiation through specific gene expression
... during chondrocyte differentiation in Uhrf1 ΔLimb/ΔLimb ...regulate chondrocyte differentiation by coordinating the transcriptome at the level of DNA ...
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Coordination of chondrocyte differentiation and joint formation byα 5β1 integrin in the developing appendicular skeleton
... The important structural function of the extracellular matrix (ECM) in the mature cartilage suggests that the components of the ECM and integrins (receptors for ECM proteins) (Bokel and Brown, 2002; Hynes, 2002) exert a ...
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Loss of Sox9 function results in defective chondrocyte differentiation of mouse embryonic stem cells in vitro
... analyzed differentiation of Sox9-/- embryonic stem (ES) cells in vitro to elucidate which steps of chondrocyte differentiation are affected by loss of Sox9 ...cell differentiation via embryoid ...
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Precocious chondrocyte differentiation disrupts skeletal growth in Kabuki syndrome mice
... precocious chondrocyte differentiation to proceed ...KS1 chondrocyte gene expression profile through modulation of a single disrupted target gene, Shox2, fits with our model that KMT2D acts on ...
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A role for age related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis
... enhanced chondrocyte hypertrophy indicated by increased expression of type X ...repressing chondrocyte terminal diff ...altered chondrocyte diff erentiation and early OA development ...in ...
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EFTUD2 gene deficiency disrupts osteoblast maturation and inhibits chondrocyte differentiation via activation of the p53 signaling pathway
... and differentiation period (P < ...early differentiation and maturation of the extracellular matrix, showed no change before cell confluence and was decreased by 90% when entering the ...
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Regulation of chondrogenesis and chondrocyte differentiation by stress
... Chondrogenesis and endochondral ossification are the cartilage differentiation processes that lead to skeletal formation and growth in the developing vertebrate as well as skeletal repair in the adult. The ...
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Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix associated autologous chondrocyte transplantation
... for chondrocyte-based cartilage repair procedures, especially in the discussion whether chondrocyte differentiation potential is independent of OA etiology or ...
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Capability of Cartilage Extract to In Vitro Differentiation of Rat Mesenchymal Stem Cells (MSCs) to Chondrocyte Lineage
... induce differentiation of rat derived omentum tissue MSCs (rOT-MSCs) into chondrocyte cells (CCs) was ...and chondrocyte differentiation was ...induce differentiation of MSCs into ...
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Wnt/β catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation
... bone. Chondrocyte hypertrophy is required for ossification because hypertrophic chondrocytes secrete factors such as Indian hedgehog (Ihh) and vascular endothelial growth factors (Vegfs), which are required for ...
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In vitro functional characterization of prostaglandin-endoperoxide synthase 2 during chondrocyte hypertrophic differentiation
... To investigate whether Cox-2 affects relevant marker gene expression, we have performed expression analysis of the Cox-2 expressing stable line and compared with controls. As illustrated in Figure 5, we detected ...
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Rationale and pre-clinical evidences for the use of autologous cartilage micrografts in cartilage repair
... articular chondrocyte transplantation, the use of Rigenera® pro- cedure would improve the feasibility of biological treat- ments in the ...affect chondrocyte viability and influence chondrocyte ...
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HIF1α regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis
... To study the possibility that prechondrogenic cells in the Prx1- Hif1 ␣ forming digits cease to differentiate, we examined the expression of Sox9 in E11.5-E13.5 Prx1-Hif1 ␣ autopods by section in situ hybridization. To ...
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1. Study of chondrogenesis in murine mesenchymal stem cells as a cell therapy in cartilage repair by in silico approach
... for chondrocyte differentiation through literature search from Springer, PubMed, American Journal of biochemical engineering, Medica Odontologica ...cell differentiation to ...
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p16INK4a and its regulator miR 24 link senescence and chondrocyte terminal differentiation associated matrix remodeling in osteoarthritis
... chondrogenic differentiation to re- capitulate in vitro all stages of ...a chondrocyte differentiation marker such as collagen IIB at days 7 to 14 and in a concomitant man- ner with MMP13, a ...
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