chondroitin sulfate
Colorimetric estimation of Chondroitin Sulfate in bulk drug and pharmaceutical formulation using cationic dye Methylene Blue
... quantitating chondroitin sulfate needs enzymatic digestion followed by disaccharide analyses, include reverse phase high performance liquid chromatography[9] (HPLC), anion-exchange chromatography[10] and ...
7
Effect of introduction of chondroitin sulfate into polymer peptide conjugate responding to intracellular signals
... of chondroitin sulfate (CS), which induces receptor-medicated endocytosis, into polymers mainly with a high cationic charge density such as polyethylenimine can increase tumor-targeted gene ...
7
Analysis of the disaccharides derived from hyaluronic acid and chondroitin sulfate by capillary electrophoresis with sample stacking
... CE conditions for monitoring the unsaturated disaccharides of hyaluronic acid (di-HA) and chondroitin sulfate (di-CS) using an alkaline tetraborate buffer, electrokinetic sample injection, and UV absorption ...
9
Porcine Circovirus 2 Uses Heparan Sulfate and Chondroitin Sulfate B Glycosaminoglycans as Receptors for Its Attachment to Host Cells
... heparan sulfate (HS), chondroitin sulfate B (CS-B), but not CS-A, and keratan sulfate reduced PCV2 infection when these GAG were incubated with PCV2 prior to and during inoculation of 3D4/31 ...
8
Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis
... Chondroitin sulfate (CS) is an important glycosaminoglycan and is mainly found in the extracellular matrix as CS proteoglycans. In the brain, CS proteoglycans are highly concentrated in perineuronal nets ...
10
CONDITIONS OF FORMATION OF EUGLOBULIN LIKE PRECIPITATES FROM SERUM PROTEINS AND CHONDROITIN SULFATE
... b When chondroitin sulfate is added in increasing amounts to the diluted dialyzed serum in water, the protein precipitated increases to a peak and then diminishes as shown in Figure 2, c[r] ...
6
Utilization of Chondroitin Sulfate as an Anhydrous Proton Conductor
... Chondroitin sulfate C (CSC), one of the natural polysaccharides, is present in the connective tissue, brain, and cartilage. Therefore, the utilization of CSC has been limited to biological materials. In ...
12
Extraction of Glycosaminoglycans Containing Glucosamine and Chondroitin Sulfate from Chicken Claw Cartilage
... between chondroitin sulfate and hyaluronic acid are regarded as polymer of ...joints. Chondroitin sulfate is a component that is composed of N-acetyl-galactosamine sulfate and ...
9
Synthesis, NMR Solution Structure, and Neuritogenic Activity of Chondroitin Sulfate D and E
... Here, we report the synthesis of a CS-D and CS-E tetrasaccharide in a step-efficient manner. By generating a disaccharide precursor from hydrolysis of polysaccharides, we were able to streamline the synthesis and reduce ...
185
The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells
... TM consists of five domains, including an N-terminal lectin-like domain, followed by six epidermal growth fac- tor (EGF)-like repeats, a serine/threonine – rich domain, a transmembrane domain, and a cytoplasmic domain ...
12
Chondroitin sulfate functionalized mesostructured silica nanoparticles as biocompatible carriers for drug delivery
... coat chondroitin sulfate-based macromer onto amined mesoporous silica nanoparticles to generate pH responsive ...that chondroitin sulfate is effectively anchored on the surface of the silica ...
13
FORMULATION OF CHONDROITIN SULFATE NANOPARTICLE WITH CHITOSAN AND KAPPA CARRAGEENAN USING THE IONIC GELATION METHOD
... of chondroitin sulfate nanoparticles The greater the percent transmittance indicated that the size of the particles in the dispersion system is getting ...(K), chondroitin sulfate (Ks), and ...
5
Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin 1beta in human chondrocytes
... either chondroitin sulfate (CS) or dermatan sulfate ...dermatan sulfate epimerase ( DSE ) genes for core protein synthesis and for DS linkage region synthe- sis, ...
11
Nanoscale modification of porous gelatin scaffolds with chondroitin sulfate for corneal stromal tissue engineering
... Abstract: Recent studies reflect the importance of using naturally occurring biopolymers as three-dimensional corneal keratocyte scaffolds and suggest that the porous structure of gelatin materials may play an important ...
14
HPLC and mass spectrometry analysis of the free radical degradation of chondroitin sulfate and its implications in osteoarthritis
... We have proposed a mechanism for the free radical degradation of CS, an important structural component of articular cartilage. The degradation of this molecule has been associated with the development of arthritis. As ...
95
Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate
... heparan sulfate proteoglycans (HSPGs), the importance of chondroitin sulfate proteoglycans (CSPGs) in modulating signaling pathways involving hedgehog proteins, wingless-related proteins and ...
10
Local increase level of chondroitin sulfate induces changes in the rhombencephalic neural crest migration
... Int J De' lIiol ~2 207 216 (1998) 207 Original Arlid" Local increase level of chondroitin sulfate induces changes in the rhombencephalic neural crest migration JOSE A MORO BALBAs', ANGEL GATO, MARiA I[.] ...
10
Glucosamine and chondroitin sulfate supplementation to treat symptomatic disc degeneration: Biochemical rationale and case report
... and chondroitin sulfate preparations are widely used as food supplements against osteoarthritis, but critics are skeptical about their efficacy, because of the lack of convincing clinical trials and a ...
8
Discovery of New Roles for Chondroitin Sulfate in Neurotrophin Signaling and Retinotopic Development
... and chondroitin sulfate, including fibroblast growth factor 2 (FGF-2) and its receptor FGFR1, the malarial protein VAR2CSA, and tumor necrosis factor-α ...
310
Investigation of Receptors for the Modulation of Neuronal Growth by Chondroitin Sulfate
... and chondroitin sulfate, we first tested the binding of the receptor proteins that were available as soluble, Fc hybrid proteins to various CS motifs first via microarray assay to look for evidence of ...
163