chromatin remodeler
Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle
... The influenza virus paradox. Viruses do not possess the full equipment needed to express their genomes; they must thus use host cell factors and compete for and manipulate the host cell to their own benefit. Influenza ...
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Singh, Hari Raj (2018): Allosteric activation mechanism of a human oncogenic chromatin remodeler ALC1. Dissertation, LMU München: Medizinische Fakultät
... In my dissertation I have demonstrated for the first time that the ATPase domain and the macrodomain of ALC1 physically interact and that this interaction ends upon PARylation both in vivo and in vitro. ALC1 is kept ...
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The Chromatin Remodeler Isw1 Prevents CAG Repeat Expansions During Transcription in Saccharomyces cerevisiae
... the chromatin remodeling needed to prevent repeat ...the chromatin remodeler Isw1 is required to prevent CAG repeat expansions during ...the chromatin structure at the CAG repeat, thereby ...
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Schwarz, Marianne Ursula (2018): Investigation of nucleosome remodeling by the chromatin remodeler INO80 with a combination of biochemical and single-molecule approaches. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... from chromatin (Lafon et ...known chromatin remodeler that, as such, is sufficient to actively organize gene promoter regions in vitro (section ...
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miR-151-5p, targeting chromatin remodeler SMARCA5, as a marker for the BRCAness phenotype
... In recent years, the assessment of biomarkers useful for “precision medicine” has been a hot topic in research. The involvement of microRNAs in the pathogenesis of breast cancer has been highly investigated with the aim ...
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Maintenance of Heterochromatin Boundary and Nucleosome Composition at Promoters by the Asf1 Histone Chaperone and SWR1-C Chromatin Remodeler in Saccharomyces cerevisiae
... ABSTRACT Chromatin remodeling complexes cooperate to regulate gene promoters and to define chromatin ...silencing-related chromatin factors in the maintenance of native heterochromatic structures and ...
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Gerhold, Christian-Benedikt (2012): Structural biochemistry of actin-related protein 8 within its INO80 chromatin remodeler environment. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... DNA methylation primarily takes place at position 5 of cytosine within CpG dimers that are prevalently organized in so called CpG island which are located in regions of large repetitive DNA sequences or gene promotor ...
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ATM and p400 : characterisation of a novel interaction between a DNA repair enzyme and a chromatin remodeler : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry
... Negative Ampere Adaptor 2 Ampicillin Ammonium persulphate Apurnic or Apyrimidic Ataxia Telangiectasia Ataxia Telangiectasia Mutated Adenosine triphosphate ATM and Rad3-related BRG1-assoc[r] ...
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Tosi, Alessandro (2013): Dissection of the topology, structure and function of the INO80 chromatin remodeler. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... unambiguously clarify, if H2A.Z promotes destabilization or stabilization of chromatin (Abbott et al., 2001; Fan et al., 2002; Placek et al., 2005; Thambirajah et al., 2006; Zhang et al., 2005). The interaction ...
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ATM and p400 : characterisation of a novel interaction between a DNA repair enzyme and a chromatin remodeler : a thesis presented to Massey University in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Biochemistry
... Acetylation of ATM by TIP60 is required for ATM activation in the presence of DNA damage and the SANT domain of p400 has been previously shown to inhibit the histone acetyl transferase a[r] ...
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Fenn, Sebastian (2011): Structural biochemistry of the INO80 chromatin remodeler reveals an unexpected function of its two subunits Arp4 and Arp8. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... within chromatin remodelers (Galarneau et al, 2000), such functions do not readily explain why Arp4 coexists with actin in all complexes it is found (Dion et al, ...modify chromatin, but not in other DNA ...
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Arabidopsis Chromatin Remodeler Brahma: Its Functional Interplay with Polycomb Proteins and The REF6 Histone Demethylase
... marked chromatin, PRC1 catalyzes monoubiquitination at lysine 119 on histone H2A (H2AK119ub1) and results in the compaction of chromatin and gene silencing (Shao et ...target chromatin by lysine 4- ...
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GATA3 dependent cellular reprogramming requires activation domain dependent recruitment of a chromatin remodeler
... inaccessible chromatin and fails to remodel local architecture to a transposition-permissible state – were fundamentally different than the other two major ...alter chromatin and transcrip- tional status at ...
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Immunohistochemical analysis of chromatin remodeler DAXX in high grade urothelial carcinoma
... Histones are subject to a variety of post-translational modifications, including acetylation of lysines. Such modifications play fundamental roles in gene regulation and other chromatin-based processes. ...
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Chromatin remodeler HELLS maintains glioma stem cells through E2F3 and MYC
... Other chromatin remodelers were reported to play roles in DNA damage repair (27); however, our findings, together with the results of Unoki and coworkers suggest that HELLS may also serve functions in DNA damage ...
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The chromatin remodeler Mi 2β is required for establishment of the basal epidermis and normal differentiation of its progeny
... a chromatin environment permissive for the gene expression changes required in the specified path of ...mediate chromatin remodeling during early differentiation of the integument is distinct from the ...
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Epigenetic Repression of Herpes Simplex Virus Infection by the Nucleosome Remodeler CHD3
... the chromatin remodeler chromodomain helicase DNA binding (CHD3) protein is identified as an important component of the initial repression of the herpesvirus ge- ...the chromatin associated with the ...
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IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas
... In addition to these covalent histone modifications, ATP-dependent chromatin remodeling complexes facili- tate access of nucleosomal DNA. ATRX is an example of such a chromatin remodeler. We ...
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Histone variants in pluripotency and disease
... the chromatin remodeler Chd1 (Gaspar-Maia et ...open chromatin, despite the lack of significant changes in gene expression, with an increase in the heterochromatin mark ...maintain chromatin ...
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NET23/STING promotes chromatin compaction from the nuclear envelope
... The goal of a cell in response to pathogen infection is to prevent the propagation of the pathogen within the host organism. A core mechanism to do this is to induce apoptosis; however, many pathogens have mechanisms for ...
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