Chromosomal Instability
HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity
... HIPK2, a cell fate decision kinase inactivated in several human cancers, is thought to exert its oncosuppressing activity through its p53-dependent and -independent apoptotic function. However, a HIPK2 role in cell ...
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Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesis
... embryonic fibroblasts (MEFs) with the kinase dead KE mutant of cyclin D1 led to aneuploidy, abnormalities in mitotic spindle formation, autosome amplification, and chromosomal instability (CIN) by gene ...
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Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cells
... By contrast, the SUM159 cell line, which by aCGH exhib- ited very few copy number changes characterized by two highly focal areas of gene amplification, expressed cyclin E levels similar to the other cell lines in the ...
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Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis
... Telomere shortening limits the proliferative capacity of a cell, but perhaps surprisingly, shortening is also known to be associated with increased rates of tumor initiation. A current hypothesis suggests that telomere ...
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<p>Chromosomal Instability in Farmers Exposed to Pesticides: High Prevalence of Clonal and Non-Clonal Chromosomal Alterations</p>
... concerning chromosomal damage in occupationally exposed people is ...6 Chromosomal alterations (CAs) related to pesticide exposure have been identi fi ed in several popula- tions, and while some signi fi cant ...
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Chromosomal instability and cancer: a complex relationship with therapeutic potential
... Chromosomal instability (CIN) is a hallmark of human neoplasms. Despite its widespread prevalence, knowledge of the mechanisms and contributions of CIN in cancer has been elusive. It is now evident that the ...
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Epanchintsev, Alexey (2008): Analysis of c-MYC-induced chromosomal instability and generation of a conditional microRNA expression system. Dissertation, LMU München: Fakultät für Biologie
... of chromosomal instability and elevated levels of spontaneous tumors in aged animals (Weaver et ...Unexpectedly, chromosomal instability caused by CENP-E reduction was shown to rather inhibit ...
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ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
... Chromosomal instability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression signature; however, the mechanism of CIN is poorly ...governing chromosomal ...
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Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll
... tumours, chromosomal instability (CIN) has been associated with the initiation of tumorigenesis [4], the development of drug resistance, and the poor prognosis of cancer patients after chemotherapy ...
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Mitochondrial ribosomal protein S18-2 evokes chromosomal instability and transforms primary rat skin fibroblasts
... Here we report that, upon overexpression of S18-2 protein, primary rat skin fibroblasts underwent cell transformation. Cells passed more than 300 population doublings, and two out of three tested clones gave rise to ...
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Chromosomal instability and cancer predisposition: insights from studies on the breast cancer susceptibility gene BRCA2
... into chromosomal substrates are inefficiently repaired by homology-directed mechanisms, although repair by nonhomologous end-joining is ...induces chromosomal instability characterized by spontaneous ...
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Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells
... An additional source of intra-tumor heterogeneity is genetic heterogeneity resulting from DNA sequence variation and/or whole chromosome and focal copy number variations (CNVs). Whole chromosome CNVs are generated by ...
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Review Perspective: Potential impact and therapeutic implications of oncogenic PI3K activation on chromosomal instability
... tolerate chromosomal instability, which – even if occurring in a low fraction of the cell population – might help to facilitate and/or drive tumour ...of chromosomal instability could be ...
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Chromosomal instability and copy number alterations in Barrett’s esophagus and esophageal adenocarcinoma
... assess chromosomal instability as a predictor of progression in ...specific chromosomal instability compared to previous platforms that required combined STR analysis of LOH and DNA content by ...
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Vitamin C may exert variable effects on viability and proliferation of HeLa cells exhibiting high and low chromosomal instability
... Background. Chromosomal instability (CIN), defined as abnormality in chromosome structure or number, is the hallmark of malignancies. The role of vitamin C in cancer treatment is controversial and its ...
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Aneuploidy and chromosomal instability in cancer: a jackpot to chaos
... Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of mutations conferring aggressive or drug-resistant phenotypes during cancer ...evolution. Chromosomal ...
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Merotelic attachments and non-homologous end joining are the basis of chromosomal instability
... Although the large majority of solid tumors show a combination of mitotic spindle defects and chromosomal instability, little is known about the mechanisms that govern the initial steps in tumorigenesis. ...
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Autophagy regulates the survival of cells with chromosomal instability
... Chromosomal instability (CIN) refers to genomic instability in which cells have gained or lost chromosomes or chromosomal fragments. A high level of CIN is common in solid tumours and is ...
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High chromosomal instability in workers occupationally exposed to solvents and paint removers
... of Chromosomal alterations was found in the exposed group in comparison with those observed in the unexposed ...by chromosomal breaks (58 %), structural (41.2 %) and numerical chromosomal alterations ...
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Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells
... The proliferation rate of mutant embryonic cells, however, remained constant with continual passaging, despite the fact that aneuploidy and chromosome rearrangements were frequently detected in these NSC cultures, and ...
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