chromosome loss
Following the Fate of Bacterial Cells Experiencing Sudden Chromosome Loss
... Macromolecules are preserved and remain functional in DLCs. A living cell exhibits dynamic coordination between the key cellular processes of replication, transcription, and transla- tion. DLCs afford tracking of RNA and ...
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Estimating Tempo and Mode of Y Chromosome Turnover: Explaining Y Chromosome Loss With the Fragile Y Hypothesis
... What then can explain the relative stability of Y chromo- somes in Polyphaga? We propose the fragile Y hypothesis: when proper segregation of the sex chromosomes depends on chiasmata, recurring selection to reduce ...
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Sex chromosome loss and the pseudoautosomal region genes in hematological malignancies
... although loss of a sex chromosome is observed in a broad range of hematological malignancies, how it cooperates in disease development is less ...sex chromosome genes, driven by sex chromosome ...
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ASSOCIATION OF DISOMIC CHROMOSOME LOSS WITH EMS-INDUCED CONVERSION IN YEAST
... I show here that: (1) the strength of the association between ethyl methanesulfonate (EMS) -induced centromere- adjacent conversion and disomic chromosome loss remains constant, i[r] ...
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Effect of the Major Repeat Sequence on Chromosome Loss in Candida albicans
... There are several possible explanations for the association of MRS size with chromosome loss. The MRS could be a pre- ferred site for cohesin binding, making sister chromatids with larger sequences late in ...
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Hyperactivation of the Silencing Proteins, Sir2p and Sir3p, Causes Chromosome Loss
... Overexpression of SIR2 or SZR.3 is toxic: Deletion of SIR2, SIR.3, or SIR4 leads to an identical phenotype in which the silent mating type loci are fully derepressed, [r] ...
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GENIC CONTROL OF CHROMOSOME LOSS AND NONDISJUNCTION IN DROSOPHILA MELANOGASTER
... Frequencies of nullo-X and diplo-X eggs are increased to about 2 percent and 1 percent, respectively, as if the occurrence of true nondisjunction at about 1 percent had been supe[r] ...
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CHROMOSOME LOSS CAUSED BY ULTRAVIOLET TREATMENT OF DROSOPHILA SPERMATOZOA
... (4) a process upon which ultraviolet irradiation could have no effect. However, such males caused by aberrant meiotic or pre-meiotic divisions should occur as frequen[r] ...
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Investigation of chromosome Y loss in men with schizophrenia
... on chromosome 1 (176-bp fragment) and MYPT2 on chromo- some Y (two copies of 181-bp ...on chromosome 3 (140-bp fragment) and the X chromosome (144-bp fragment), we verified that there were no false ...
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A FACS-Optimized Screen Identifies Regulators of Genome Stability in Candida albicans
... or chromosome truncation versus chromosome loss in the Bfp ⫺ Gfp ⫹ ...156. Chromosome loss events correspond to isolates in which both SNPs 95 and 156 became ...by chromosome ...
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Senescence Mutants of Saccharomyces cerevisiae With a Defect in Telomere Replication Identify Three Additional EST Genes
... quency of chromosome loss (data not shown); the ap- pearance of this increased chromosome instability was delayed, similar to the delay previously exhibited by estl-A [r] ...
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Spo12 is a limiting factor that interacts with the cell cycle protein kinases Dbf2 and Dbf20, which are involved in mitotic chromatid disjunction.
... T o find out whether loss of function by itself caused chromosome loss, it was necessary to measure chro- mosome loss when the DBF2 gene was absent, but under condit[r] ...
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Identification and cloning of the CHL4 gene controlling chromosome segregation in yeast.
... A visual chromosome fragment stability assay (a half- sector method): The sector assay allows a direct determi- nation of the rates of chromosome loss (1 :O segregation)[r] ...
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CHL12, a gene essential for the fidelity of chromosome transmission in the yeast Saccharomyces cerevisiae.
... Previously we described the isolation of yeast chl (for chromosome loss) mutants using novel methods of se- lection (KOUPRINA et al. In the mutants, chromosome ZZZ is [r] ...
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Sex chromosome to autosome transposition events counter Y chromosome gene loss in mammals
... Y chromosome has lost nearly all of the approximately 640 genes it once shared with the X chromosome ...Y chromosome across eight mammals (human, chimpanzee, rhesus macaque, mar- moset, mouse, rat, ...
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Nondisjunctional Segregations in Drosophila Female Meiosis I Are Preceded by Homolog Malorientation at Metaphase Arrest
... significant loss is consistent with the observation that all metaphase- arrested chromosomes are found in a single mass at wild- type rates in ald females (the exceptions being oocytes still in prometaphase, as ...
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Susceptibility to Medium-Chain Fatty Acids Is Associated with Trisomy of Chromosome 7 in Candida albicans
... of chromosome 5 (i5L) confers resistance to fluconazole ...addition, chromosome 5L (chr5L) contains some genes encoding predicted efflux pumps, such as ...of chromosome 5 also results in elevated ...
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Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations
... of chromosome 11 allele loss occurring in non-MEN1 somatotrophinomas, indicate that a recessive oncogene on 11q13 is specifically involved in the monoclonal development of ...allele loss of ...
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Selective Loss of Sperm Bearing a Compound Chromosome in the Drosophila Female
... The storage organs of female flies contain the same ratio of C(2)EN and nullo-2 sperm as that recovered in adult progeny: Following mating, female Drosophila store a fra[r] ...
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Aneuploidy as a mechanism for stress induced liver adaptation
... numerical chromosome abnormalities, rendering them differentially resistant to ...on chromosome 16. Loss of the remaining Hgd allele protects from fumarylacetoacetate hydrolase (Fah) deficiency, a ...
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