Chronic Chagas disease
Serological Diagnosis of Chronic Chagas Disease: Is It Time for a Change?
... Architect Chagas or other similar new-generation tests, as a single technique for the diagnosis of chronic Chagas disease in blood banks and clinical laboratories in both areas that are ...
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ELISA versus PCR for diagnosis of chronic Chagas disease: systematic review and meta analysis
... about chronic Chagas disease diagnosis since 1980, however little knowledge reached clinical practice with current recommended standards up to ...of disease or not; clear description of ...
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Characterization of an Immunodominant Antigenic Epitope from Trypanosoma cruzi as a Biomarker of Chronic Chagas' Disease Pathology
... for chronic Chagas’ disease diagnosis are very sensitive; however, they do not allow discrimi- nation of the patient’s clinical stages of the ...from chronic Chagas’ disease ...
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A retrospective study on the influence of siblings’ relatedness in Bolivian patients with chronic Chagas disease
... It must be noted that the results of the aforementioned studies about the genetic determinants of end-organ damage in chronic Chagas disease have highly heteroge- neous results, even between cohorts ...
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Detection and characterization of antigens in urine of patients with acute, congenital, and chronic Chagas' disease
... In a recent investigation, Umezawa et al. (25) used a mono- specific polyclonal antiserum raised against T. cruzi recombi- nant antigen that recognized a parasite protein eliminated in the urine of 60% of patients with ...
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Trypanosoma cruzi strain TcI is associated with chronic Chagas disease in the Brazilian Amazon
... and chronic cases that indicate a new epidemiological profile of the ...of disease control measures, complementary PCR as a tool for DTU classifi- cation should also be highlighted, due to limited data on ...
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Serological Evaluation of Specific-Antibody Levels in Patients Treated for Chronic Chagas' Disease
... the chronic phase, and antibodies become the hallmark of this phase because they are often present at high ...the chronic phase, the para- sites disappear, as do those antibodies that were formerly ...the ...
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Effect of mild aerobic training on the myocardium of mice with chronic Chagas disease
... in Chagas heart disease, without ventricular dysfunction, by cardiac magnetic resonance and found that the presence of myocardial fibrosis is closely related to ...
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Differential expression of proteins in genetically distinct Trypanosoma cruzi samples (TcI and TcII DTUs) isolated from chronic Chagas disease cardiac patients
... As for heat-shock proteins, Urményi et al. [21] reviewed their relevance in the context of T. cruzi biology. It is known that this protozoan parasite has a complex life-cycle involving invertebrate and vertebrate hosts ...
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Inhibition of ER Stress by 2-Aminopurine Treatment Modulates Cardiomyopathy in a Murine Chronic Chagas Disease Model
... demonstrated a significant increase in the cardiac mRNA levels of collagen I and III in the infected mice 145... 7 compared to uninfected mice.[r] ...
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Intramyocardial transplantation of cardiac mesenchymal stem cells reduces myocarditis in a model of chronic Chagas disease cardiomyopathy
... Different cell types, such as bone marrow cells, mesen- chymal stem cells (MSCs) from adipose tissue, and skeletal myoblasts, have been tested in basic and applied clinical studies [1-4]. Bone marrow cells have ...
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The history of Chagas disease
... afterwards Chagas also discovered that the parasite was infective to several other laboratory animals ...[44]. Chagas was sure that he had found a patho- genic organism of a human infectious disease ...
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Trypanosoma cruzi Recombinant Complement Regulatory Protein: a Novel Antigen for Use in an Enzyme Linked Immunosorbent Assay for Diagnosis of Chagas' Disease
... diagnosing chronic Chagas’ disease, there is also a lack of reliable or applicable means to verify cure of patients after drug treatment, particularly in the chronic phase of the ...the ...
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Current and developing therapeutic agents in the treatment of Chagas disease
... with chronic Chagas disease who acquire AIDS or in whom immunosuppressor therapy is administered must receive treatment at the same dose as the group men- tioned above for 5 or more ...for ...
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In vitro responses to Leishmania antigens by lymphocytes from patients with leishmaniasis or Chagas' disease
... Antigens of Leishmania chagasi were evaluated by determining their ability to elicit in vitro proliferation and cytokine production in peripheral blood lymphocytes and in T cell lines and clones from patients with ...
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Evaluation of Adult Chronic Chagas' Heart Disease Diagnosis by Molecular and Serological Methods
... with chronic Chagas’ disease have been ...the chronic phase, which is evidenced by an absence of tissue failure; therefore, their probability of detecting parasites was much higher ...from ...
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Antibodies to an Epitope from the Cha Human Autoantigen Are Markers of Chagas' Disease
... with chronic Chagas’ disease from Venezuela and Argentina were ...including chronic patients treated with antiparasite drugs (Radanil or ...de Chagas Argentina, and sera from Venezuela ...
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Purification and characterization of an 80 kilodalton Trypanosoma cruzi urinary antigen
... cruzi IgG antibodies present in rabbit hyperimmune serum and in sera from human patients with acute, congenital, or chronic Chagas' disease, from chronically infected mice with or withou[r] ...
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Autoimmunity in Chagas' disease Identification of cardiac myosin B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient
... icry between cardiac myosin and B13 in CCC pathogenesis. In this paper, we obtained heart-infiltrating T cell clones from CCC patients to assess whether molecular mimicry be- tween cardiac myosin and B13 is directly ...
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Highly Effective Serodiagnosis for Chagas' Disease
... Many proteins of Trypanosoma cruzi, the causative agent of Chagas’ disease, contain characteristic arrays of highly repetitive immunogenic amino acid motifs. Diagnostic tests using these motifs in monomeric ...
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