Chronic GvHD
The Relationship between STR-PCR Chimerism Analysis and Chronic GvHD following Hematopoietic Stem Cell Transplantation
... and chronic GvHD, recurrence and death are shown in Table ...1, chronic GvHD occurred in 40 patients (69%), 25 patients ...limited GvHD and 15 ...
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Therapy with mycophenolate mofetil for refractory acute and chronic GVHD.
... The ability to administer treatment over a prolonged period of time and the availability of an intravenous and oral formulation are advantages for the use of MMF, allowing for multi-agent therapy, particularly for ...
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Biology of chronic graft-versus-host disease: implications for a future therapeutic approach.
... to chronic GVHD are not as well understood as those leading to acute ...acute GVHD has been recognized as a risk factor for chronic GVHD, not all cases of acute GVHD evolve into ...
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Hematopoietic stem cell transplantation
... Major causes of death are late recurrence of original malignant disease, cGvHD, late infections without GvHD, secondary malignancies, pulmonary complications, and cardiac complications. Up to 20% of long-term ...
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PubMedCentral-PMC4715914.pdf
... B cells play a role in the development of chronic GVHD and CD27+ B cells are constitutively activated in patients with this disease (13, 30). For this study a detailed analysis of plasma BAFF levels and ...
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Treatment change as a predictor of outcome among patients with classic chronic graft-versus-host disease
... of chronic GVHD and the use of female donor for male recipients were the only risk factors associated with treatment ...for chronic GVHD 12 , these factors ...
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Prognostic Implications of the NIH Consensus Criteria in Children with Chronic Graft versus Host Disease
... tingto chronic GvHD incidence using a Cox proportional hazards regression model: age of patient and donor, gender, underlying disease, donor type, cell source, donor-recipient sex mismatch, HLA-C mismatch, ...
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Ibrutinib treatment ameliorates murine chronic graft versus host disease
... 4). Chronic GVHD progression in this model is defined as a greater than 2-point increase in cGVHD score from the initiation of therapy (Supplemental Table ...
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Ruxolitinib in steroid refractory graft-vs.-host disease: a case report
... and GvHD severity by histology studies and suppression of the serum inflammatory cytokine ...in GvHD target organs demonstrated the ability of Ruxolitinib to shift T cell ...51 chronic GvHD ...
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Hepatocyte growth factor prevents lupus nephritis in a murine lupus model of chronic graft versus host disease
... HGF gene transfection effectively prevented the proteinuria and histopathological changes associated with glomerulone- phritis, primary biliary cirrhosis and Sjogren's syndrome. HGF gene transfection greatly reduced the ...
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C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans
... human chronic GvHD patients, serum CXCL13 levels are elevated (44) and are associated with low Tfh cell numbers in peripheral blood (44, 53), suggesting that circulating Tfh cells have been recruited into ...
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A fast and fatal course of bronchiectasis: an unusual rare expression of chronic graft versus host disease. A case report
... In summary, bronchiectasis can develop soon after BMT in patients with chronic GVHD and the course of them can be rapid and fatal. This case demon- strates that lung injury and bronchiectasis that occur ...
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Ocular Graft versus Host Disease: A Review of Clinical Manifestations, Diagnostic Approaches and Treatment
... ocular GVHD is contributed mainly by conjunctival and lacrimal gland abnormality but involvement of other ophthalmic structures is also documented especially in chronic ...In chronic ocular surface ...
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Enhanced allostimulatory activity of host antigen presenting cells in old mice intensifies acute graft versus host disease
... acute GVHD by reducing host resistance to donor T cell ...reaction. GVHD itself also damages the thymus, resulting in a loss of negative selection and emergence of host-reactive clones ...for chronic ...
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Value of Interleukin-7 and Interleukin-15 as Predictors of Graft Versus Host Disease in Recipients of Allogeneic Bone Marrow Transplantation
... with GVHD encountered in the study population was ...of chronic GVHD, plasma level of IL-7 at day +14 was negatively correlated to mucus cGVHD with a P-value of ...both GVHD free survival ...
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A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia
... and chronic GVHD (aGVHD and cGVHD), relapse incidence (RI), non- relapse mortality (NRM), and graft-versus-host relapse- free survival (GRFS) ...Acute GVHD was graded according to the modified ...
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Azithromycin for Prevention of Graft-Versus-Host Disease: A Randomized Placebo-Controlled Trial
... In general, the protective effect of azithromycinon on the incidence of GvHD could not be demonstrated based on the results of this trial. The only remarkable finding was a marginally significant lower incidence ...
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Prognostic utility of routine chimerism testing at 2 to 6 months after allogeneic hematopoietic cell transplantation.
... and chronic GVHD was censored at the onset of recurrent malignancy or date of last contact, whichever occurred ...and chronic GVHD for patients with low donor chimerism compared to those ...
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Two dose levels of rabbit antithymocyte globulin as graft-versus-host disease prophylaxis in haploidentical stem cell transplantation: a multicenter randomized study
... Acute GVHD; allo-HSCT: Allogeneic hematopoietic stem cell transplantation; Ara-C: Cytarabine; ATG: Antithymocyte globulin; cGVHD: Chronic GVHD; CMV: Cytomegalovirus; CR: Complete remission; CsA: ...
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IL10 and IL10 receptor gene variation and outcomes after unrelated and related hematopoietic cell transplantation.
... acute GVHD at day 100 after unrelated HCT was 37%, compared to 19% after HCT from HLA-identical siblings (Table ...acute GVHD (data not shown), grades III-IV acute GVHD, extensive chronic ...
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