chronic lymphocytic leukemia cells
Cytotoxic Activity of Valproic Acid on Primary Chronic Lymphocytic Leukemia Cells
... leukemic cells after VPA treatment showed significant downregula- tion of BCL2, BCL-XL, XIAP, AVEN cIAP, AKT and ATM, whereas BCLA1, APAF1 and TP53 as well as genes encoding caspases 8, 2, 3, 6, 9 and 10 were ...
8
Cytochalasin B is a potent mitogen for chronic lymphocytic leukemia cells in vitro
... It is widely accepted that the neoplastic B cells from patients with chronic lymphocytic leukemia (CLL) respond poorly to common mitogens. The fungal metabolite cytochalasin B (0.5 ...
10
Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5
... Human T cell antigens defined by monoclonal antibodies: the 65,000 dalton antigen of T cells T65 is also found on the chronic lymphocytic leukemia cells bearing surface immunoglobulin.. [r] ...
9
Pyridine nucleotide transhydrogenase in normal human and leukemic leukocytes
... The enzyme activity in the sediment of cells from patients with chronic lymphocytic, acute myeloid, and acute lymphocytic leukemia was significantly higher than that in cells from normal[r] ...
6
Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells
... that chronic lymphocytic leukemia (CLL) B-cells display a strong tendency to differentiate into antibody-secreting cells (ASCs) and thus may be amenable to differentiation ...
20
Histiocytic sarcoma combined with acute monocytic leukemia: a case report
... blastic leukemia [8, 9, 11], and chronic lymphocytic leukemia [12], in which the HS was shown to share mo- lecular or cytogenetic features with associated ...germ cells, which has been ...
6
Case Report Chronic myelogenous leukemia following small lymphocytic lymphoma: a case report and review of literature
... Both SLL and CML are relatively common hematologic malignancies, but CML following SLL in one patient has not been reported yet. It is hard to discriminate our patient with CML is therapy-related or not. Maybe the ...
6
Temporal Dynamics of Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors: Longitudinal Immunogenetic Evidence
... Examination of the IG sequences of CLL subset 4 antibodies highlighted their resemblance to pathogenic anti-DNA an- tibodies, since both carry IgG-switched BcRs with long positively charged VH CDR3s enriched with ...
7
The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia
... populations, cells were simultaneously labeled with anti-CD3-FITC, anti-CD19-Phycoerythrin (PE; Becton Dickinson) and annexin V-Pacific Blue (PB; Life ...tumor cells except for MM, where tumor cells ...
16
<p>CD5-negative chronic lymphocytic leukemia/small lymphocytic lymphoma in a patient with gastrointestinal mantle cell lymphoma: an unusual case report</p>
... antiviral treatment can lead to a complete remission of hepatitis C virus (HCV)-associated low-grade NHL, sug- gesting a causative role of HCV in these tumors. 12 Meta- analyses further show HBV-infected patients have ...
5
<p>Pathophysiologic Mechanisms And Management Of Large Granular Lymphocytic Leukemia Associated Pure Red Cell Aplasia</p>
... granular lymphocytic leukemia (LGLL) is a chronic clonal lymphoproli- ferative disease of mature T or NK cells, and produces a variety of hematological abnorm- ...
12
Molecular pathogenesis of chronic lymphocytic leukemia
... Chronic lymphocytic leukemia (CLL) is the most common leukemia in ...B cells, a model sup- ported by frequent B cell receptor repertoire skewing and ...
8
Apoptosis inducers in chronic lymphocytic leukemia
... Flavopiridol is a semisynthetic flavone derived from rohitukine (an alkaloid isolated from Indian plants). Its chemical structure is shown in Figure 2. To the best of our knowledge, this flavonoid was the first apoptosis ...
17
www.ijcep.com /IJCEP1002005 Case Report An uncommon case of de novo CD10 CD5 mantle cell lymphoma mimics follicle center B cell lymphoma
... neoplastic cells may be confused with diffuse large cell lymphoma or other blastic hematolymphoid ...phoma cells in these cases have relatively more abundant cytoplasm compared to the classical form, ...
7
A rare association of chronic lymphocytic leukemia with c ANCA positive Wegener’s granulomatosis: a case report
... , erythrocyte sedimentation rate 61 mm/h, fibrinogen level 517.6 mg/dl, fibrin monomer- s—absent, and C-reactive protein 7.73–192 mg/l. The bacteriological exam of the conjunctiva secretions re- vealed the following: the ...
5
Role of microRNA in chronic lymphocytic leukemia onset and progression
... prognosis, progression, and drug resistance [7]. A signa- ture profile describing 13 microRNAs able to differenti- ate aggressive and indolent CLL was reported [8]. Patients with high miR-21 and miR-155 had a higher risk ...
6
Profile of venetoclax and its potential in the context of treatment of relapsed or refractory chronic lymphocytic leukemia
... CLL cells from peripheral blood by, for example, a CD20 antibody, while a redistribution of these cells from the lymphoid tissue to this compartment is triggered by the BTK ...
12
Targeted treatment for chronic lymphocytic leukemia: clinical potential of obinutuzumab
... stronger ADCC and direct cell death induction as well as weaker CDC were repeatedly demonstrated in comparison to known type I antibodies rituximab and ofatumumab. Enhanced ADCC was achieved by modifying the Fc frag- ...
7
Case Report A case study of t(14;22)(q32;q11) involving immunoglobulin heavy and light chain in follicular lymphoma
... lymphoid cells were positive for CD45, CD10, CD79a, CD20, BCL2, BCL6, and MUM1, but negative for CD3, CD5, cyclin D1, and c-myc (Figure 1C, 1D, 1G, ...dendritic cells positive for CD21 was also detected ...
7
Radiation-induced myeloid leukemia in murine models
... myeloid leukemia in ...increased leukemia in- duction frequency until a critical dose of around 3 Gy, after which point the incidence rapidly drops off ...of leukemia is less than 1% [35]; however, ...
10