CIA-mice
Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice
... In this study, we use the well-established type II collagen-induced arthritis (CIA) mouse model, which engenders symptoms which mimic human disease to evaluate the putative therapeutic effect of TAK1 inhib- ition ...
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Brazilin isolated from Caesalpinia sappan L inhibits rheumatoid arthritis activity in a type II collagen induced arthritis mouse model
... DBA/1J mice were divided into four groups ( n = 10). Three groups of mice received intradermal injections of inducer bovine type-II collagen (BTIIC; 2 mg/ml in ...of mice. At the 42nd day, ...
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B1a cells play a pathogenic role in the development of autoimmune arthritis
... In this study, we show that peritoneal B1a cells undergo proliferative expansion and migrate to peripheral lymphoid organs and inflamed joint tissue during the development of murine CIA. Moreover, adoptive ...
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Apoptotic cell infusion treats ongoing collagen induced arthritis, even in the presence of methotrexate, and is synergic with anti TNF therapy
... (CIA) mice received or did not receive apoptotic cells, with or without MTX, or MTX alone and were scored daily ...five mice per group from one of two representative experiments; *p < ...vs. ...
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Original Article Individualized moderate aerobic exercise improves physical capacity and prevents weight loss in collagen-induced arthritis
... healthy mice, the chronic effect of treadmill training results in an increased maximal oxygen uptake (VO2max), which allows mice to run at higher speeds ...the CIA-EXE and CIA groups, which ...
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Quantification of bone changes in a collagen-induced arthritis mouse model by reconstructed three dimensional micro-CT
... All mice were imaged prior to the immunization with CII at week 0 and subsequently when mice developed symp- tomatic evidence of polyarthritis at weeks 4, 7, and ...and CIA mice at week 0 are ...
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Supplement of 5 hydroxytryptophan before induction suppresses inflammation and collagen induced arthritis
... from CIA mice at day 36 post-immunization and the concentrations of IL-6, IL-17, TNFα and IFNγ were measured by cytometric bead array kits (BD ...DBA/1 mice were treated with 5-HTP in the presence of ...
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Therapeutic effect of neutralizing endogenous IL 18 activity in the collagen induced model of arthritis
... Several hypotheses can be put forward to explain these results. One possible explanation is the induc- tion of a neutralizing antibody response to the bind- ing protein in the animals receiving the higher con- ...
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Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis
... 3 mice in each) were performed (control: 100.0 ± 17.4%, CIA: ...and CIA mice (left and middle panel, respectively; n = 4 mice in each ...of CIA mice according to the ...
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OX40 signaling is involved in the autoactivation of CD4+CD28− T cells and contributes to the pathogenesis of autoimmune arthritis
... OX40 (CD134) and its ligand OX40L (CD252) are mem- bers of the TNF/TNFR superfamily. OX40 (TNFR super- family member 4, TNFRSF4) is predominantly expressed by activated T cells, whereas the primary source of OX40L (TNF ...
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Monoclonal Anti-HMGB1 (High Mobility Group Box Chromosomal Protein 1) Antibody Protection in Two Experimental Arthritis Models
... in CIA is more acute and dramatic in the joints compared with those of rheumatoid arthritis ...–/– mice is milder than that of CIA and also has many similarities with human rheumatoid arthritis ...
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Treatment with recombinant interferon β reduces inflammation and slows cartilage destruction in the collagen induced arthritis model of rheumatoid arthritis
... in CIA in mice by IFN- β gene therapy ...DBA/1 mice were infected with a retrovirus express- ing murine IFN-β and were injected intraperitoneally into CIA mice before and after the ...
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The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis
... during CIA towards a Naive ...ES-62-treated CIA animals, presenting proportion values as pie charts (a) from a single representative experiment using pooled samples from three mice in each ...
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Therapeutic effect of erythroid differentiation regulator 1 (Erdr1) on collagen-induced arthritis in DBA/1J mouse
... control, CIA mice subsequently treated with PBS showed severely inflamed paws with redness and swelling, whereas CIA mice treated rErdr1 showed significant reduction of paw inflammation ...
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Identification of collagen induced arthritis loci in aged multiparous female mice
... The mice used in the present study, (NFR/N × ...to CIA, in spite of both having the MHC class II A beta genes [15], we wanted to test the susceptibility to inflammatory dis- ease in mice from this ...
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Immunization with T cell receptor V beta chain peptides deletes pathogenic T cells and prevents the induction of collagen induced arthritis in mice
... arthritis-protected mice (Table V) strongly implicate the development of an effective humoral immune re- sponse against the pathogenic T cells in the induction of pro- tective immunity against ...Although ...
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Encyclopedia of Espionage, Intelligence & Security Vol I By Lee Lerner & Brenda Lerner pdf
... the CIA could carry out assassinations of political leaders who were assumed to be a threat to ...the CIA on General Abdul Karim Kassem of Iraq by planting a poi- soned handkerchief in his suit pocket, but ...
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Interleukin 10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen induced arthritis
... cell mice com- pared to WT B cell mice, the number of FoxP3 + Tregs and FoxP3 + expression were similar in both groups dur- ing ...diseases. Mice immunized with collagen in CFA develop disease three- ...
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ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints
... A key question therefore relates to the trigger that switches IL-22 from a pro- to an antiinflammatory cytokine in CIA. Our data suggest that this occurs around the time of onset of joint pathology (days 20–25) as ...
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Phosphatase and tensin homolog (PTEN) in antigen presenting cells controls Th17 mediated autoimmune arthritis
... In CIA, significantly reduced levels of IL-17 were present in the serum and also in draining LNs after in- duction of ...-/- mice, but the quality of the ...-/- mice reflects an inability to mount an ...
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