Cigarette smoke (CS)
Cigarette smoke–induced neurogenic inflammation is mediated by α,β unsaturated aldehydes and the TRPA1 receptor in rodents
... Inhaled cigarette smoke (CS) causes an early inflammatory response in the airways that is partly neurogenic ...rodents, CS-evoked neurogenic plasma protein leakage (1) is mediated by release ...
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Ursolic acid alleviates airway-vessel remodeling and muscle consumption in cigarette smoke-induced emphysema rats
... Chronic obstructive pulmonary disease (COPD) is a sys- temic disease characterized by persistent respiratory symptoms and airway limitation. It has high prevalence and associated mortality, with a prevalence among people ...
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Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response
... cigarette smoke involvement in DC decreased maturation even in subjects without COPD ...to cigarette smoke, we report a decreased lung DC maturation and a lower production of IL-1β and IL- 23 ...
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Mouse Protocadherin 1 gene expression is regulated by cigarette smoke exposure in vivo
... that CS exposure reproducibly induces loss of Pcdh1 expression in all three short-term exposure models and in the 2 months chronic CS exposure model presented here does indicate that CS exposure is a ...
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Cigarette smoke differentially modulates dendritic cell maturation and function in time
... of cigarette smoke on DCs in mouse models and human ...that cigarette smoke expos- ure impairs dendritic cell maturation and T cell prolif- eration in thoracic lymph nodes of ...that ...
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CD147 increases mucus secretion induced by cigarette smoke in COPD
... Cigarette smoke is a primary cause of mucus secretion, and a variety of signaling molecules participate in the regulation of MUC5AC production induced by CS extract [9, 10, ...with CS extract; ...
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Critical role of aldehydes in cigarette smoke-induced acute airway inflammation
... disease; CS: Cigarette smoke; WF-CS: Water filtered CS; CSE: CS extract; WF-CSE: WF-CS extract; MCP- 1: Monocyte chemotactic protein-1; MIP-1 α : Macrophage inflammatory ...
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Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required?
... mice. Cigarette smoke may activate lung resident cells, including epithelial cells and macrophages, which then release inflammatory media- tors, including cytokines (eg TNF- α and KC (mouse IL-8)) and ...
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Cigarette smoke inhibition of ion transport in canine tracheal epithelium
... to cigarette smoke decreased the short circuit current and transepithelial ...of cigarette smoke was reversible, was not observed upon exposure of the submucosal surface to smoke, and ...
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Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model
... Methods: Thirty normal Sprague Dawley (SD) rats were divided into control (n=10), CSE (n=10), and CSE plus simvastatin (n=10) groups. Animals were whole-body exposed to the cigarette smoke in the box for 1 ...
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Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells
... that bring about these intracellular changes and acute in- flammation in lung epithelial cells are not well understood. Upregulation of cytokine gene expression in epithelial cells has been linked to activation of ...
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CSEO – the Cigarette Smoke Exposure Ontology
... exposure. Most exposure experiments follow a similar routine summarized as follows: the design, factors, and protocols of an experiment must be defined before conducting the experiment. This is often the case for ...
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The Apoe−/− mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction
... following smoking cessation, although the triacylglycerol concentration increased. Hepatic triacylglycerol accumu- lation is indicative of fatty liver disease, but the observed increase did not appear to reflect ...
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<p>Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD</p>
... n=16), cigarette smoke- associated chronic obstructive pulmonary disease (COPD, n=16), α1-anti trypsin deficiency not in therapy (AATD-noT, n=16) and AATD in augmentation therapy (AATD- AT, ...in CS, ...
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Original Article The anti-inflammatory and anti-remodeling effect of tiotropium bromide in the subacute cigarette exposure mouse model
... the CS and tiotropium groups, the mice were exposed to cigarette smoke for 2 h twice daily, 5 days per week for 5 weeks by using whole- body Smoke Exposure ...whole-body Smoke Exposure ...
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<p>Lipid metabolism in chronic obstructive pulmonary disease</p>
... 87,88 Cigarette smoke exposure could increase the level of C16- Cer, and C16-Cer accumulation contributed to mitochon- drial damage and PINK1-mediated ...reduced CS-induced acute and chronic lung in ...
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PINK1-PARK2-mediated mitophagy in COPD and IPF pathogeneses
... of CS exposure with rising incidence worldwide [15, 55]. CS, the major cause of COPD, is rich in toxic components, including ROS, and a variety of biological responses to cigarette smoke ...
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Interaction of the hydrogen sulfide system with the oxytocin system in the injured mouse heart
... in cigarette smoke (CS)-exposed CSE − / − mice compared to wildtype ...(WT). CS increases myometrial OTR expression, but to this point, no data are available on the effects CS exposure ...
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Micronutrients and many important factors that affect the physiological functions of toll-like receptors
... 14; CS: Cigarette smoke; DAMPs: Damage- associated molecular patterns; DCs: Dendritic cells; EMT: Epithelial- mesenchymal transition; GC: Glucocorticoids; HCV: Hepatitis C virus; HFD: High-fat diet; ...
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Effects of Exposure to Total Particulate Matter of Cashew Nuts Shell in the Respiratory System of Mice with Chronic Obstructive Pulmonary Disease
... and CS groups) was performed via intranasal instillation during 20 days after protocol of exposure to cigarette smoke or ambiente air (CTRL ...
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