Circulating Epithelial Tumor Cells
Characteristics of circulating tumor cells in organ metastases, prognosis, and T lymphocyte mediated immune response
... Abstract: Circulating tumor cells (CTCs) possess profound influence on tumor metastases and disease ...T cells was ...of epithelial– mesenchymal circulating tumor ...
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Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells
... thousands cells) as well as post-enrichment residual blood components, resulting in markedly interfering subsequent CTC identification performed by FISH or ...of epithelial tumor cells to the ...
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EMT and tumor metastasis
... CTC: Circulating tumor cells; FOXC1: Forkhead box C1; HER2: Human epidermal growth factor receptor 2; CSC: Cancer stem cells; EpCAM: Epithelial cellular adhesion molecule; HAT: Histone ...
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Technical challenges in the isolation and analysis of circulating tumor cells
... with epithelial biomarkers, several studies have shown lack of specificity and sensitivity when using EpCAM as a biological marker for CTC ...normal epithelial cells in the circulation, for example ...
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<p>Clinical Significance of Red Cell Distribution Width and Circulating Tumor Cells with an Epithelial–Mesenchymal Transition Phenotype in Lung Adenocarcinoma</p>
... All statistical analysis was performed using SPSS version 19.0 (SPSS Inc., Chicago, Illinois, USA) and the graphs were drawn using GraphPad Prism version 5.0 (GraphPad software, Inc., La Jolla, CA, USA). Time-dependent ...
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Detection of circulating tumor cells by p75NTR expression in patients with esophageal cancer
... Mononuclear cells were enriched from 3 mL of per- ipheral blood using LymphoPrep™ (Nycomed AS, Oslo, ...(human epithelial antigen)-125, dilution 1:100], fluorescein isothiocyanate (FITC)-conjugated ...
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Clinical and Experimental Importance of Circulating Tumor Cells in Prostate Cancer
... EpCAM [epithelial cell adhesion molecule]/CK [cytokeratin] expression as they enter the bloodstream via a process known as epithelial-to-mesenchymal transition [EMT] 72 ). In fact, currently, the only U.S. ...
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Analysis of the hormone receptor status of circulating tumor cell subpopulations based on epithelial-mesenchymal transition: a proof-of-principle study on the heterogeneity of circulating tumor cells
... of circulating tumor cells (CTCs) has been demonstrated to be a prognostic indicator in metastatic breast cancer, the heterogeneous characteristics of CTCs, such as variations in the ...
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Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients
... primary tumor tissues and successfully employed as genetic signature to predict OS in high-grade serous OC ...to tumor biopsy samples, circulating cell-free DNA (cf-DNA) and circulating ...
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Wedge shaped microfluidic chip for circulating tumor cells isolation and its clinical significance in gastric cancer
... on epithelial cell adhesion molecule (EpCAM) marker to enrich and isolate CTCs [18], was the first and only semi- automated CTCs enumeration assay approved by FDA for the diagnosis of metastatic breast, prostate, ...
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EMT, CTCs and CSCs in tumor relapse and drug-resistance
... stem cells (CSCs), which are highly resistant to ...in circulating tumor cells (CTCs) of some cancer patients manifest phenotypes of both CSCs and epithelial-mesenchymal transition ...
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Association of a novel circulating tumor DNA next generating sequencing platform with circulating tumor cells (CTCs) and CTC clusters in metastatic breast cancer
... We observed that higher number of CTCs was associ- ated with genomic alterations in ESR1, GATA3, CDH1, and CCND1, while lower number of CTCs was associ- ated with CDKN2A alterations. In independent valid- ation, these ...
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Clinical relevance and biology of circulating tumor cells
... dual epithelial growth factor receptor (EGFR) and HER-2 inhibitor lapatinib ...primary tumor. Tumor progression was related to recurrence of CTCs that were both HER-2 and EGFR negative, suggesting ...
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Circulating and disseminated tumor cells from breast cancer patient derived xenograft bearing mice as a novel model to study metastasis
... of epithelial markers (that is, epithelial cell adhesion molecule (EpCAM) and/or “epithelial” cyto- keratins 8, 18, 19) ...the epithelial markers ...“human” tumor cells for the ...
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Tumorigenic potential of circulating prostate tumor cells
... prostate epithelial cells grew as renal grafts only when recombined with fetal urogenital mesenchyme ...cancer cells with fetal urogenital ...scattered cells inside the matrigel matrix without ...
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Clinical applications of liquid biopsy as prognostic and predictive biomarkers in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA
... for tumor recurrence in HCC patients after surgery, especially in patient subgroups with AFP levels of ≤400 ...HCC cells express EpCAM, which only identifies low numbers of CTCs in approximately 30–40% of ...
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The viable circulating tumor cells with cancer stem cells feature, where is the way out?
... tached tumor cells in PB, CTCs enumeration was thought to be an important method in the clinic relevance ...different tumor types were quite disparity ...marrow-derived cells or altering the ...
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<p>The Frequency of Circulating Tumour Cells and the Correlation with the Clinical Response to Standard Chemoradiotherapy in Locally Advanced Nasopharyngeal Carcinoma: A Prospective Study</p>
... Circulating tumor cells in the blood of poorly differentiated nasal squamous cell carcinoma patients: correlation with treatment response. Comparison of circulating tumour cells[r] ...
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Emerging concepts in liquid biopsies
... individual cells, each mutation represents a low frequency event and special NGS methods for detection of such rare mutations are ...stem cells [63, ...
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Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids – the state of art
... Circulating tumor cells (CTCs) are present in blood- stream during the formation and growth of tumors, in low concentration and result from metastatic precursor cells of lymphovasculature ...
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