circulating vaccine-derived poliovirus
Managing the risk of circulating vaccine derived poliovirus during the endgame: oral poliovirus vaccine needs
... stockpile vaccine needs in the event of cVDPV outbreaks of serotypes 1 or 3 after OPV13 cessation, more bOPV use than strictly needed be- fore OPV13 cessation appears a necessary and prudent ...
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The global switch from trivalent oral polio vaccine (tOPV) to bivalent oral polio vaccine (bOPV): facts, experiences and lessons learned from the south south zone; Nigeria, April 2016
... polio vaccine; cVDPV: Circulating vaccine derived polio virus; cVDPV2: Circulating vaccine-derived poliovirus type 2; DRC: Democratic republic of Congo; EOC: ...
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Emergence and Localized Circulation of a Vaccine Derived Poliovirus in an Isolated Mountain Community in Guangxi, China
... 1 circulating vaccine-derived poliovirus (cVDPV) was isolated from one case patient with acute flaccid paralysis (AFP) and six unimmunized healthy contacts in isolated mountain villages in ...
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Limited and Localized Outbreak of Newly Emergent Type 2 Vaccine-Derived Poliovirus in Sichuan, China
... From August 2011 to February 2012, an outbreak caused by type 2 circulating vaccine-derived poliovirus (cVDPV) occurred in Aba County, Sichuan, China. During the outbreak, four type 2 VDPVs ...
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Development of Thermostable Lyophilized Sabin Inactivated Poliovirus Vaccine
... PV vaccine [IPV]) given by injection that was developed by Jonas Salk in 1955 and a live attenuated PV (oral PV vaccine [OPV]) given by mouth that was developed by Albert Sabin in 1961 (6, ...the ...
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Excretion of Wild-Type and Vaccine-Derived Poliovirus in the Feces of Poliovirus Receptor-Transgenic Mice
... of vaccine-derived poliovirus strains, quasispecies will arise with an increased transmissibility and ...as circulating vaccine-derived poliovirus (cVDPV) ...
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Health and economic consequences of different options for timing the coordinated global cessation of the three oral poliovirus vaccine serotypes
... wild poliovirus (WPV) serotypes ...oral poliovirus vaccine (OPV) in both routine immunization (RI) and supplemental immunization activities (SIAs), which provides humoral and intestinal im- munity to ...
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Impact of Exogenous Sequences on the Characteristics of an Epidemic Type 2 Recombinant Vaccine-Derived Poliovirus
... to circulating VDPVs (cVDPVs) have brought to the forefront the depth of entero- virus evolution and the influence it may have on the eradica- tion program ...low vaccine coverage in nine different ...
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Modeling the prevalence of immunodeficiency associated long term vaccine derived poliovirus excretors and the potential benefits of antiviral drugs
... oral poliovirus vaccine (OPV) after assurance of global interruption of wild poliovirus (WPV) transmission to eliminate the risks of poliomyel- itis disease associated with continued OPV use [1, ...
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Spread of Vaccine-Derived Poliovirus from a Paralytic Case in an Immunodeficient Child: an Insight into the Natural Evolution of Oral Polio Vaccine
... and circulating or cVDPVs, causing polio out- breaks during extensive circulation in populations with poor vaccine coverage and hygiene, crowding, ...of vaccine poliovirus. Therefore, dividing ...
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Circulation of Type 1 Vaccine-Derived Poliovirus in the Philippines in 2001
... to poliovirus, especially where wild poliovirus circulation has ceased, viruses derived from OPV may circulate within a population, cause cases of paralytic poliomyelitis, and accumulate further ...
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Analysis of vaccination campaign effectiveness and population immunity to support and sustain polio elimination in Nigeria
... wild poliovirus (WPV) and circulating vaccine-derived polio- virus (cVDPV) cases, and by comparing campaign effect- iveness estimates to LQAS ...
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Long-Term Excretion of Vaccine-Derived Poliovirus by a Healthy Child
... 2-derived poliovirus for an estimated 20 years and is still ex- creting at present ...excreting poliovirus. Derivatives of the Sabin live attenuated vaccine strains present in OPV have been ...
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Long-Term Circulation of Vaccine-Derived Poliovirus That Causes Paralytic Disease
... efficacious poliovirus vaccines, the oral live vaccine made from the Sabin strains (oral poliovirus vaccine [OPV]) and the inactivated Salk vaccine, has resulted in a dramatic worldwide ...
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Evolution of Circulating Wild Poliovirus and of Vaccine-Derived Poliovirus in an Immunodeficient Patient: a Unifying Model
... Statistical analysis of rare-codon conservation. A codon was defined as rare if its abundance was no more than 30% of that of its most abundant synonym in the poliovirus codon usage table. Five families of codons ...
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Characterization of outbreak response strategies and potential vaccine stockpile needs for the polio endgame
... of circulating vaccine-derived polioviruses (cVDPVs) ...inactivated poliovirus vaccine (IPV) for outbreak re- ...immunodeficiency-associated vaccine-derived po- lioviruses ...
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Genomic Analysis of Vaccine Derived Poliovirus Strains in Stool Specimens by Combination of Full Length PCR and Oligonucleotide Microarray Hybridization
... In this communication we describe a rapid method for am- plification of complete copies of poliovirus cDNA directly from stool samples. The FL-PCR amplification method was origi- nally proposed in our laboratory ...
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Poliovirus-specific immunoglobulin A in persons vaccinated with inactivated poliovirus vaccine in The Netherlands.
... to poliovirus at a concentra- tion of ...for poliovirus type 1, 1-10C9E6 for type 2, and 2-13D9 for type 3 ...formaldehyde-inactivated poliovirus was added to each ...the vaccine production ...
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Intratypic Recombination among Lineages of Type 1 Vaccine-Derived Poliovirus Emerging during Chronic Infection of an Immunodeficient Patient
... partial (1916-nucleotide) P1/capsid interval compared. The in- ternal nodes on the phylogenetic tree (Fig. 5) represent point estimates of the times of divergence of lineages A to E during the chronic infection. The ...
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RESPONSE OF INFANTS TO TRIVALENT POLIOVIRUS VACCINE (SABIN STRAINS)
... RESPONSE OF INFANTS TO TRIVALENT POLIOVIRUS VACCINE (SABIN. http://pediatrics.aappublications.org/content/40/6/980[r] ...
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