circumsporozoite protein
A highly infectious Plasmodium yoelii parasite, bearing Plasmodium falciparum circumsporozoite protein
... mosquito salivary glands [2, 3]. Radiation or genetically attenuated whole Spz vaccine candidates target the pre- erythrocytic stages in the life cycle of the parasite [4–6] and are shown to be highly protective, but ...
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Mechanisms of protective immune responses induced by the Plasmodium falciparum circumsporozoite protein based, self assembling protein nanoparticle vaccine
... subunit protein vaccines targeting various parasite proteins of choice, used in combination with immune-boosting adjuvants, have been examined and have yielded promising but limited ...subunit ...
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Chelation of Ca2+ ions by a peptide from the repeat region of the Plasmodium falciparum circumsporozoite protein
... falciparum circumsporozoite protein allowed the proposal of a left-handed helical conformation for this ...this protein, indicated that they bind Ca 2+ ions in helical ...
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Genetic polymorphisms in the circumsporozoite protein of Plasmodium malariae show a geographical bias
... Comparative genomics of Plasmodium spp., includ- ing P. malariae, has been used to elucidate the evolu- tionary history of Plasmodium spp. that infect humans [4,5]. Population genetic studies of P. malariae should be ...
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The effect of immunization schedule with the malaria vaccine candidate RTS,S/AS01E on protective efficacy and anti circumsporozoite protein antibody avidity in African infants
... falciparum circumsporozoite protein (CSP) and the concentration of Immunoglobulin G (IgG) against the repeat region of CSP following vaccination is associated with protection from ...
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T cell epitope polymorphisms of the Plasmodium falciparum circumsporozoite protein among field isolates from Sierra Leone: age dependent haplotype distribution?
... falciparum circumsporozoite protein (Pf-CSP) is the most abundant protein on the sporozoite's surface and has a sequence comprising a central repeat that is flanked by polymorphic N-terminal and ...
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Vaccine induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection
... circumsporozoite protein (CSP) and a moderate CD4 + T cell response. The individual contribution of these adaptive immune responses to protection from infection remains unknown. Here, we found that ...
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Endogenously expressed NH2 terminus of circumsporozoite protein interferes with sporozoite invasion of mosquito salivary glands
... proteins, circumsporozoite binding protein (CSPBP) and saglin, were identified as receptors for sporozoites and these interact with the parasite-expressed circumsporozoite protein (CSP) and ...
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Evaluation of circumsporozoite protein of Plasmodium vivax to estimate its prevalence in the Republic of Korea: an observational study of incidence
... sporogony-stage protein that exists on the surface membrane of all plasmodium ...of circumsporozoite protein and annual parasite incidence in ...
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False positive circumsporozoite protein ELISA: a challenge for the estimation of the entomological inoculation rate of malaria and for vector incrimination
... The entomological inoculation rate (EIR) is an important indicator in estimating malaria transmission and the impact of vector control. It is defined as the number of infective bites per person per unit of time. In ...
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A monoclonal antibody based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum
... Several vaccine candidates, targeting different stages of the parasite life cycle have been developed and shown varying degrees of success upon evaluation [8, 9]. The most advanced malaria vaccine candidate directed ...
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Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites
... Plasmodium sporozoites enter the blood stream through the bite of an infectious mosquito, after which they quickly migrate to the liver and invade hepatocytes. After multiplication within hepatocytes, merozoites are ...
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Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon
... Numerous studies conducted in a variety of epidemio- logical settings have revealed that the levels and sero- prevalence of sporozoite antibodies, especially those against the repetitive epitope of ...
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The Th1 Immune Response to Plasmodium falciparum Circumsporozoite Protein Is Boosted by Adenovirus Vectors 35 and 26 with a Homologous Insert
... The recent association of Th1 cytokine-expressing CD4 ⫹ T cells, induced with the RTS,S vaccine, with protection against malaria infection in the human challenge model has reinforced the view that induction of a broad ...
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Analysis of polymorphisms in the circumsporozoite protein gene of Plasmodium vivax isolates from Henan Province, China
... surface protein 1 (msp-1), merozo- ite surface proteins 3 (msp-3) and mitochondrial DNA ...zoite protein (CSP) found in all malaria parasites is the major cell surface protein of the Plasmodium ...
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Plasmodium berghei circumsporozoite protein encapsulated in oligomannose coated liposomes confers protection against sporozoite infection in mice
... BCA protein assay kit (Thermo Fisher Scientific, ...combinant protein (PbMSP-1 and PbCSP, respectively) were observed with SDS-PAGE (Figure ...recombinant protein entrapment as described previously ...
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Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenic regions.
... In the for- mer species, the repeat sequence is conserved both within and between alleles, whereas in the latter spe- cies there is evidence that positive selection may ha[r] ...
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Serological responses to a soluble recombinant chimeric Plasmodium vivax circumsporozoite protein in VK210 and VK247 population
... Since repeat region was involved B and T cells epi- topes that different number of csp repeat of P. vivax pa- tient serum against the chimeric protein was analysed. Although only limited known number of repeat ...
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Genetic polymorphism of the N terminal region in circumsporozoite surface protein of Plasmodium falciparum field isolates from Sudan
... In Sudan, malaria continues to spread despite the efforts of the National Malaria Control Programme (NMCP). Many studies in Sudan have focused on addressing the situation of malaria treatment efficacy [3– 5], while ...
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Synthesis and immunological evaluation of peptide-based vaccine candidates against malaria
... The circumsporozoite protein (CSP) is a major surface pro- tein of the sporozoite (pre-erythrocytic) stage of malaria para- site and is the antigenic target of numerous vaccines against malaria, including ...
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