Cisplatin and Apoptosis
Cisplatin fails to induce puma mediated apoptosis in mucosal melanomas
... with cisplatin, only MM cells decreased mRNA and protein expression of CDK1/Cdk1, whereas CM cells tended to stabilize Cdk1 protein and therefore promote the maintenance of cell ...repair, apoptosis and ...
10
The effect of caffeine on cisplatin-induced apoptosis of lung cancer cells
... of cisplatin-induced apoptosis in the lung cancer cells, we determined the phosphoryl- ation levels of CHK1 (Ser 317 /Ser 345 ), ATM (Ser 1981 ), and p53 (Ser 15 ), three proteins involved in the DNA ...
9
The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells
... In recent years, tetrandrine (TET) has garnered increasing attention due to its potential use as a novel anticancer agent either alone or in combination with other chemotherapeutic drugs [10–16]. TET, a bis- ...
10
CXCL12 suppresses cisplatin-induced apoptosis through activation of JAK2/STAT3 signaling in human non-small-cell lung cancer cells
... To our knowledge, there are few reports about the anti- apoptosis effect of CXCL12 on human lung cancer cells. Additionally, it was found that CXCL12 induced the resis- tance of the NSCLC cell to cisplatin ...
10
Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma
... and apoptosis initiated through the TNF receptor ...inhibited cisplatin- induced apoptosis in OTSCC cells and this effect was as- sociated with induction of the anti-apoptotic proteins caspase-9, ...
9
Original Article Compound K, a metabolite of ginseng saponin, enhances the susceptibility of osteosarcoma cells to cisplatin and induces cell apoptosis via mitochondrion-mediated pathways
... with cisplatin on OS cells, in vitro and in vivo, and to investigate CK as a potential novel therapeutic for treatment of ...and cisplatin (a first-line chemotherapeutic agent for the treatment of OS) were ...
10
Sildenafil potentiates the antitumor activity of cisplatin by induction of apoptosis and inhibition of proliferation and angiogenesis
... sildenafil-induced apoptosis of tumor ...and cisplatin induced higher expression of caspase-3 compared with groups treated with cisplatin alone, indicating more apoptosis of the cancer ...with ...
12
Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells
... to enhance the effect of cisplatin. Compared with cispl- atin alone, combined AZD7762 significantly increased caspase-3, -9 activation and PARP shear in both cell lines. We also found that the combination of ...
11
Original Article Effects of okadaic acid combined with cisplatin on the proliferation and apoptosis of human lung adenocarcinoma A549 cells
... with cisplatin (DDP) on the proliferation and apoptosis of human lung cancer A549 cells and to explore the potential ...with cisplatin and OA at different ...
8
Original Article Metformin induces apoptosis of osteosarcoma U2OS and 143B cells through the mitochondria-dependent pathway and potentiates the anti-neoplastic activity of cisplatin in vivo
... cells apoptosis via the mitochondria-depen- dent signal pathway ...metformin-induced apoptosis is medi- ated by the accumulation of reactive oxygen species (ROS) via the mitochondria-mediated signal pathway ...
9
<p>α-Hederin Increases The Apoptosis Of Cisplatin-Resistant Gastric Cancer Cells By Activating Mitochondrial Pathway In Vivo And Vitro</p>
... Cisplatin – resistant gastric cancer cells were subcuta- neously inoculated into the dorsal area of the male BALB/c nude mice (5 – 6 weeks old, Beijing Vital River Laboratory Animal Technology, China) which were ...
14
Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells
... of apoptosis and ...induced apoptosis and necroptosis even more strongly, as evidenced by the increased apoptotic and necrotic numbers, higher expression and activation of Caspase3, Caspase8, RIPK3 and ...
14
Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer
... with cisplatin in ovarian ...and apoptosis with the increased intracellular ROS levels, which were accompanied by obvious alterations of related proteins such as CDKs, Cyclins, Mcl-1, XIAP and ...rescued ...
14
Inhibition of Protein arginine methyltransferase 6 reduces reactive oxygen species production and attenuates aminoglycoside- and cisplatin-induced hair cell death
... or cisplatin damage increased its expression, providing the precondition for the following investigation of PRMT6 roles in ototoxic drugs-induced ...cell apoptosis were assessed in this ...and ...
18
(−)-Epigallocatechin-3-gallate derivatives combined with cisplatin exhibit synergistic inhibitory effects on non-small-cell lung cancer cells
... Lung cancer is the leading cause of cancer-related mor- tality worldwide and several efficient antibodies and drugs have been developed for its treatment [20]. Plati- num-based chemotherapy, such as cDDP, is a conven- ...
16
Essential role for acid sphingomyelinase-inhibited autophagy in melanoma response to cisplatin
... The collected melanoma transplants were fixed in ice cold 4% paraformaldehyde before being rinsed in PBS and cryo-protected overnight in 30% sucrose. Tissues were then embedded in O.C.T. Compound (Sakura, AJAlphen aan ...
15
Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition
... knockdown of UCA1 decreased chemoresistance to cisplatin/ gemcitabine by suppressing cell proliferation and inducing apoptosis, while overexpression of UCA1 increased drug Figure 5 Uc[r] ...
14
Download Download PDF
... of cisplatin both in vivo and in vitro, indicating that the cisplatin induces the activation of the death receptor ...to apoptosis. The role of Fas- and TNFR1-induced apoptosis has also been ...
8
Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway
... Materials and methods: Cells were transfected with nuclear factor erythroid-2-related fac- tor 2 (Nrf2) small interfering RNA and Nrf2 complementary DNA by using Lipofectin 2000. The cytotoxicity of cells was ...
11
Inhibition of PKCδ reduces cisplatin induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer
... on cisplatin-induced apoptosis in ...μM cisplatin for 16 hours in the absence or presence of 10 μ M rottlerin, BisI, or ...during cisplatin treatment by ...of cisplatin-induced ...
15