cisplatin resistance
A HIF independent, CD133 mediated mechanism of cisplatin resistance in glioblastoma cells
... Although HIF-1α and HIF-2α were found to be involved in the regulation of CD133 expression under hypoxia, we noted that their knockdown did not completely ablate CD133 ex- pression, suggesting that its encoding gene may ...
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PKM2 Inhibitor Shikonin Overcomes the Cisplatin Resistance in Bladder Cancer by Inducing Necroptosis
... drug resistance was usually relevant to dysregulation Bcl-2 family ...the cisplatin resistant in BC ...the cisplatin resistance in BC cells, and kill BC cells by ...in cisplatin ...
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PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells
... of cisplatin treatment with or without LB100 (Figure ...in cisplatin sensitivity by PP2A inhibition was in part due to direct increase in cisplatin ...uptake. Cisplatin uptake increased by 57% ...
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Ubiquitin ligase CHAF1B induces cisplatin resistance in lung adenocarcinoma by promoting NCOR2 degradation
... Nuclear receptor corepressor 2 (NCOR2) is a mem- ber of the family of co-inhibitors associated with thy- roid hormones and retinoic acid receptors. This protein acts as part of a multi-subunit complex of histone dea- ...
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Cisplatin resistance in non-small cell lung cancer cells is associated with an abrogation of cisplatin-induced G2/M cell cycle arrest
... to cisplatin resistance of A549 r CDDP 2000 cells. Cisplatin treatment significantly increased mRNA level of XPC, a protein downstream of p53 and crucial for DNA damage recognition, in sensitive ...
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Ku80 is highly expressed in lung adenocarcinoma and promotes cisplatin resistance
... in cisplatin resistance, we examined the effects of Ku80-siRNA on cleaved caspase-3 and cleaved ...with cisplatin treatment, might promote apoptosis by trig- gering caspases cascades in apoptotic ...
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Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer
... in cisplatin resistance caused by OGT knockdown, we inhibited autophagy using 3-methyladenine (3-MA) and bafilomycin A1 (Baf), which prevent the formation and fusion of autophagosomes, respectively (Figure ...
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Emerging role of long non-coding RNAs in cisplatin resistance
... Cisplatin resistance, either intrinsic or acquired, is a signifi- cant burden for successful cancer ...in cisplatin chemoresistance (Table 1) through mechanisms such as alterations in cellular uptake ...
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Cytoplasmic p21 expression levels determine cisplatin resistance in human testicular cancer
... as cisplatin are used as first-line treatment for many ...of cisplatin-sensitive solid tumors, but the mechanisms of chemoresistance remain ...of cisplatin-resistance in testicular embryonal ...
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<p>Exosomal Transfer Of Cisplatin-Induced miR-425-3p Confers Cisplatin Resistance In NSCLC Through Activating Autophagy</p>
... that cisplatin promoted exosome release from NSCLC cells in a concentration- dependent manner (Figure ...in cisplatin-resistant A549/DDP cells than in cisplatin-sensitive A549 cells (data not ...of ...
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ST6Gal-I sialyltransferase confers cisplatin resistance in ovarian tumor cells
... ST6Gal-I-mediated cisplatin-resistance may involve the differential sialylation of one or more drug ...Many cisplatin-resistant cell lines show reduced accumulation of cisplatin [47], pointing ...
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Targeting aldehyde dehygrogenase 1 (ALDH1) to circumvent cisplatin resistance in NSCLC
... acquired cisplatin resistance and out-survive ALDH-ve cells during cisplatin therapy, but are also enriched for the CSCs responsible for driving cisplatin-resistance in ...ALDH+ve ...
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Hypoxia-elevated circELP3 contributes to bladder cancer progression and cisplatin resistance
... Cisplatin resistance is no more than a platitude in cancer ...cancer, cisplatin-based chemotherapy is the only clinical treatment if patients have progressed to advanced stage ...that ...
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Hsp90B enhances MAST1 mediated cisplatin resistance by protecting MAST1 from proteosomal degradation
... confers cisplatin resistance to cancer cells mainly through MAST1 ...driving cisplatin resistance in human cancers ...overcoming cisplatin resistance, but their mechanism of ...
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MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1
... decreased cisplatin-induced ovarian cancer cell death ...in cisplatin- sensitive cell lines (A2780) and cisplatin-resistant cell lines ...both cisplatin-resistant cell lines (A2780/CP and ...
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Molecular mechanisms of cisplatin resistance in cervical cancer
... underlying cisplatin resistance in cervical cancer are complex and associated with the following features: 1) reduction in the intracellular accumulation of the platinum compounds (decrease in uptake, ...
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Cell fate determination in cisplatin resistance and chemosensitization
... the cisplatin treatment is largely conferred through ATR ...the cisplatin response, and that pharmacological inhibition of both has been implicated in anti-cancer treatment [5, ...
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Understanding cisplatin resistance using cellular models
... in cisplatin resistant ...other cisplatin resistant cells, although cross-resistant to many drugs, were not resistant to ...these cisplatin resistant cells, but not the H69 cells, with non-cytotoxic ...
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Identifying intracellular cisplatin interaction partners and assessing their contribution to cisplatin resistance
... intracellular cisplatin-interaction ...of cisplatin with antioxidant protein 1 (Atox1) was ...that cisplatin forms an adduct with Atox1, and that the overexpression of Atox1 reduced DNA platination ...
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Original Article MCT1 promotes the cisplatin-resistance by antagonizing Fas in epithelial ovarian cancer
... of cisplatin-resistant ovarian cancer and its possible relationship with ...in cisplatin-resistant ovarian cancer tissue and A2780/CP cells compared with sensitive ovarian cancer tissue and cell lines ...
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