Cisplatin sensitivity
Similar cisplatin sensitivity of HPV-positive and -negative HNSCC cell lines
... after cisplatin administration where marked differences in the cellular cisplatin responses were evident between cell lines of different cisplatin ...of cisplatin for each cell line we ...
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Investigation of the molecular basis of cisplatin sensitivity in testicular germ cell tumours
... increased sensitivity to cisplatin compared to the cells transfected with the vector alone, but transfection with the wild-type H-ras had no effect on cisplatin sensitivity (Gao et al, 1991; ...
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NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells
... induced cisplatin transporter CTR1 (copper transporter 1) and enhanced cisplatin sensitivity in ovarian ...model. Cisplatin-induced inhibition of cell growth was enhanced by EGCG treatment in ...
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Enhancement of cisplatin sensitivity in lewis lung carcinoma by liposome-mediated delivery of a survivin mutant
... The survivin mutant had originally gained attention because it widely and specifically promoted apoptosis and enhanced chemotherapy, and its function and mech- anism have been studied in various tumor types [9,11,12,29]. ...
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SOX17 increases the cisplatin sensitivity of an endometrial cancer cell line
... Cisplatin is the first-line chemotherapy drug, of which the most prominent mode of anticancer action involves the generation of DNA lesions followed by the activa- tion of the DNA damage response and the induction ...
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eIF3a improve cisplatin sensitivity in ovarian cancer by regulating XPC and p27 Kip1 translation
... Tissue sections (4 μm thick) were prepared from paraffin embedded blocks. After antigen retrieval treatment in 10 mM citrate buffer (pH 6.0) at 95°C for 10 min, immunostaining was performed using the Envision System ...
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Overexpression of CCDC69 activates p14ARF/MDM2/p53 pathway and confers cisplatin sensitivity
... Numerous studies have demonstrated that the tumor sup- pressor protein p14 ARF can stabilize and activate p53 by inhi- biting the E3 ligase activity and nuclear export of MDM2, which is followed by formation of the ...
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FOLR1 increases sensitivity to cisplatin treatment in ovarian cancer cells
... in cisplatin-resistant tumors [6],but whether there is a mechanistic link between FOLR1 and response to cisplatin has not been extensively ...for cisplatin sensitivity in ovarian ...
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miRNA-193a-5p repression of p73 controls Cisplatin chemoresistance in primary bone tumors
... the Cisplatin- induced apoptosis of Bone Sarcomas and that the miRNA-193a-5p, through its TAp73β’s targeting ability, consequently modulates the Cisplatin-sensitivity of these ...
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Sphingosine Kinase Regulates the Sensitivity of Dictyostelium discoideum Cells to the Anticancer Drug Cisplatin
... drug cisplatin is widely used to treat a number of tumor ...to cisplatin, whereas mutants overexpressing the enzyme were more sensitive to the ...to cisplatin. The null mutants showed increased ...
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RESISTANCE AND SENSITIVITY; COMPETITIVE MECHANISMS OF CISPLATIN
... In addition to JNK in p53 dependent apoptosis, it also induces p53 independent cell death by activating p73. JNK forms a complex with p73; any mutation in the binding site reduces the cisplatin sensitivity. ...
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Original Article PUMA enhances sensitivity of anaplastic thyroid carcinoma cells to cisplatin
... to Cisplatin in ...(c) cisplatin (d) ad-PUMA and cisplat- ...of cisplatin showed slowed SW1736 tumor growth rates, but only 10% smaller than those of the untreated SW1736 tumor (P > ...
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Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer
... to cisplatin (IC50) in an independent gastric cancer cell line panel and with survival of patients treated with chemotherapy prior to surgery but not in patients treated with surgery ...with cisplatin in ...
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Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma
... inhibited cisplatin- induced apoptosis in OTSCC cells and this effect was as- sociated with induction of the anti-apoptotic proteins caspase-9, caspase-3, and ...the sensitivity of OTSCC cells to apoptosis ...
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Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis
... Furthermore, autophagy inhibition in osteosarcoma cancer stem cells decreased cancer cell surface markers and enhanced sensitivity to hypoxic conditions and exposure to cisplatin, result[r] ...
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Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)
... Cisplatin predominantly forms intrastrand DNA cross- links that are repaired by the nucleotide excision repair (NER) system. There are two subpathways of NER; tran- scription coupled repair (TCR) which removes ...
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Transmembrane-4 L-six family member-1 (TM4SF1) promotes non-small cell lung cancer proliferation, invasion and chemo-resistance through regulating the DDR1/Akt/ERK-mTOR axis
... and cisplatin are the most commonly used chemo-therapy reagents for ...while cisplatin is known as a cell cycle-phase-nonspecific chemo-reagent ...the sensitivity of A549 and H1299 cells to ...
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MiR 338 3p Enhances Ovarian Cancer Cell Sensitivity to Cisplatin by Downregulating WNT2B
... ulates metabolism in ovarian cancer cell by inhibiting pyru- vate kinase M2 expression. In the present study, bioinformat- ics analysis and dual-luciferase reporter assay were conducted and confirmed that miR-338-3p had ...
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Epidermal growth factor regulates the in vitro sensitivity of human ovarian carcinoma cells to cisplatin
... enhance sensitivity to DDP or alter morphology in DDP-resistant human ovarian carcinoma cells despite the presence of functional EGF receptors on these ...cellular sensitivity to DDP, and that a ...
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Collateral Sensitivity to Cisplatin in KB 8 5 11 Drug resistant Cancer Cells
... 4 and allowed to attach overnight. Wells were treated in triplicate with serial dilutions of drug in a final volume of 200 µl and incubated for a further five days. Cell viability was then determined using an ...
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