Cisplatin treatment
Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells
... need. Cisplatin has demonstrated its promising potential for the treatment of TNBC in clinical trials; however, cisplatin treatment is associated with hypoxia that in turn promotes cancer stem ...
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Original Article Silencing long non-coding RNA NEAT1 enhances the suppression of cell growth, invasion, and apoptosis of bladder cancer cells under cisplatin chemotherapy
... RNA libraries preparation without poly-A selec- tion (Table 2). StringTie was used to quantify the gene expression with FPKM distribution (Figure 2A), and presented the differentially expressed genes among the three ...
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Inhibition of PKCδ reduces cisplatin induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer
... of cisplatin-induced nephrotoxicity remains unclear, and renoprotective approaches during cisplatin-based chemotherapy are ...of cisplatin nephrotoxicity, which can be effectively targeted for ...
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Ribonucleotide reductase inhibition restores platinum sensitivity in platinum resistant ovarian cancer: a Gynecologic Oncology Group Study
... to cisplatin better restored platinum-sensitivity in platinum-resistant ovarian ...after cisplatin treatment, not only increases cisplatin-mediated DNA damage in “ platinum- resistant” ovarian ...
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The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2
... in cisplatin- treated HNSCC ...chemotherapeutic treatment since La is not only overexpressed in HNSCC [3], but also in various other types of cancer like chronic myeloid leukemia [1], cervical cancer [2], ...
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Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc
... to cisplatin treatment, the effect on gene expression by cisplatin and/or kaempferol was further evaluated by analyzing mRNA levels of ABCC1, ABCC5, ABCC6, NFκB1, cMyc and CDKN1A ...2, ...
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Peripheral neurotoxic effects of cisplatin on rats and treatment with rutin
... functions. Cisplatin leads to an increased level of reactive oxygen species (ROS), which, in turn, causes an increase in lipid peroxidation and a decrease in catalase and gluta- thione peroxidase activity, ...
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Analysis of the chemotherapeutic effects of a propadiene compound on malignant ovarian cancer cells
... than cisplatin and paclitaxel, while combination treatment of cells with PHPO + cisplatin induced more apoptosis than with PHPO + paclitaxel or with cisplatin + paclitaxel (p < ...+ ...
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Structural damage of chicken red blood cells exposed to platinum nanoparticles and cisplatin
... that cisplatin treatment led to formation of keratocytes, indicating that cisplatin was haemolytic, which may be due to mechanical fragility or oxidant injury to RBC ...NP-Pt treatment caused ...
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Inositol triphosphate 3 kinase B confers cisplatin resistance by regulating NOX4 dependent redox balance
... in cisplatin-resistant cancer cells (Figure 5, A and ...promotes cisplatin-resistant cell survival and tumor growth through redox regulation using antioxidant N-acetylcys- teine ...Indeed, treatment ...
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Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma
... 6A). Cisplatin treatment also increased the expression of EGF, EGFR and SOS1 and activated the HRAS/PI3K/AKT pathway at 48 hours, while knockdown of HRAS, PI3K or AKT enhanced cisplatin-induced ...
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Oxaliplatin induces drug resistance more rapidly than cisplatin in H69 small cell lung cancer cells
... of cisplatin-resistant SCLC sublines that have been established with various cisplatin treatment regimens and eleven examples are presented in Table ...continuous cisplatin treatment ...
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Esomeprazole and pantoprazole enhance the antiproliferative effects of cisplatin on the human neuroblastoma SH-SY5Y cell line
... with cisplatin on the human neuroblastoma SH-SY5Y cell ...+ cisplatin combinations, an important loss of viability was observed in both ...with cisplatin treatment alone, esomeprazole and ...
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Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis
... and/or cisplatin treatment for 3 ...bevacizumab, cisplatin and bevacizumab + cisplatin ...and/or cisplatin treatments, with- out extrapulmonary ...bevacizumab treatment resulted ...
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COMPARATIVE STUDY OF THE TOXICITY PROFILE IN PATIENTS RECEIVING CISPLATIN PACLITAXEL VS CARBOPLATINPACLITAXEL IN OVARIAN CANCER
... the treatment of solid tumors, including ovary, head, neck, lung, and ...While cisplatin induces various toxicities including myelosuppression, ototoxicity and nephrotoxicity the major dose-limiting side ...
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Topotecan in the treatment of relapsed small cell lung cancer
... Abstract: Small cell lung cancer (SCLC) represents about 15% to 20% of all lung cancers. Chemotherapy is the cornerstone of the treatment, cisplatin–etoposide combination being the most used combination as ...
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Effects of neo adjuvant chemotherapy for oesophago gastric cancer on neuro muscular gastric function
... Histological paraffin embedded tissue blocks showing normal tissue adjacent and distant from the tumour site were selected. 5μm thick sections were baked onto 3- aminopropyltriethoxy-silane coated slides. Specific ...
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The Prevalence of the Potential Drug-Drug Interactions Involving Anticancer Drugs in China: A Retrospective Study
... standard treatment such as concurrent use of cisplatin and paclitaxel despite enhancement of drug toxicity for DDIs, the main purpose of this study was to survey the prevalence of potential DDIs between ...
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Oxaliplatin for the treatment of cisplatin resistant cancer: A systematic review
... of cisplatin were first observed in the ...received cisplatin in April 1971. Cisplatin quickly progressed through clinical trials becoming the first platinum compound approved for cancer therapy and ...
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Activation of store – operated Ca(2+) entry in cisplatin resistant leukemic cells after treatment with photoexcited fullerene C(60) and cisplatin
... Two murine leukemic cell lines – wild type, sensitive (L1210) and resistant (L1210R) to cisplatin were obtained from the Bank of Cell Lines from Hu- man and Animal Tissues of R. E. Kavetsky Institute of ...
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