Citrullinated proteins
Investigating citrullinated proteins in tumour cell lines
... gland epithelial cells and MCF-7 breast cancer cells [13]. Therefore, the identification of citrullination substrates is helpful for understanding the pathogenic mechanisms of PADs during tumorigenesis. Thus far, ...
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Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis
... to citrullinated proteins (e.g. anti-CCP [cyclic citrullinated peptide] antibodies) are highly specific for rheumatoid arthritis ...therefore citrullinated antigens are also expected to be ...
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Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis
... citrullinated proteins are no longer detectable by ...with citrullinated MBP, is more susceptible to demyelination due to the decreased compaction of the lipid bilayers and increased exposure of ...
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Rheumatoid factor, not antibodies against citrullinated proteins, is associated with baseline disease activity in rheumatoid arthritis clinical trials
... against citrullinated proteins (ACPAs) in patients with rheumatoid arthritis (RA) is well established, their association with RA disease activity remains ...
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Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity
... citrulline-containing proteins have an impressive specificity of nearly 100% in patients with rheumatoid arthritis and have been suggested to be involved in the disease ...to citrullinated rat serum albumin ...
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Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis
... against citrullinated proteins are specific and predictive markers for rheumatoid arthritis although the pathologic relevance of these antibodies remains ...cyclic citrullinated peptide, one such ...
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Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins
... on citrullinated proteins either in serum, SF or synovial tissue of RA ...between citrullinated proteins in serum and SF was already reported by Takizawa et ...also citrullinated ...
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Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis
... to citrullinated proteins (anti-cyclic-citrullinated peptide [anti-CCP] antibodies) are highly specific for rheumatoid arthritis (RA) and precede the onset of disease symptoms, indicating a ...
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Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor
... Figure 2 Box plots of anti-citrullinated protein antibody (ACPA) levels (a) and rheumatoid factor (b) in rheumatoid arthritis pa- tients depending on the presence of one shared epitope allele (SE) combined with an ...
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How citrullination invaded rheumatoid arthritis research
... of proteins in the synovium may lead to changes in important physio- logical ...processes. Citrullinated fibrinogen and citrullinated collagen type II are more immunogenic and arthritogenic in mouse ...
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Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen
... numerous citrullinated proteins have been described in synovial fluid of RA patients [16], it has not, to our knowledge, been shown that the conditions ne- cessary for PADs to be active, including an ...
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Mapping of citrullinated fibrinogen B cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance
... of citrullinated proteins and ACPA in the pathophysiology of RA is not fully understood, but it has been shown that citrullinated fibrinogen can induce arthritis in genetically susceptible (DR4-IE ...
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Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease
... The proteins citrullinated were cytokeratins of type II (1, 2, 5, 6A, 6B and 77) and type I (9, ...of citrullinated proteins both in the cytoplasm and cell ...
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Different properties of ACPA and IgM RF derived from a large dataset: further evidence of two distinct autoantibody systems
... to citrullinated proteins/peptides (ACPAs) and/or IgM rheumatoid factor (IgM-RF) ...cyclic citrullinated peptide (CCP) [4]. ACPAs target citrullinated proteins and are observed in ...
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Effectiveness of a telemonitoring intensive strategy in early rheumatoid arthritis: comparison with the conventional management approach
... Anti-citrullinated proteins antibodies; ACR: American college of rheumatology; ADA: adalimumab; AUC: area under the curve; CDAI: clinical disease activity index; CDC: comprehensive disease control; CI: ...
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The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis
... erent citrullinated proteins, such as fi brino gen, histones or ...these citrullinated proteins, indicating broad cross-reactivity between anti-CCP and these various antigens (R Toes, personal ...
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Patient’s perspective of sustained remission in rheumatoid arthritis
... In February 2004, an ongoing cohort of patients with recent-onset RA (within 12 months of symptoms onset) was initiated. At inclusion, the complete medical history and sociodemographic data were recorded in addition to ...
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Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis
... against citrullinated proteins/peptides; anti-CCP: anti-cyclic citrullinated peptide; ELISA: enzyme linked immunosorbent assay; basic-FG: fibroblast growth factor; CI: confidence interval; G-CSF: ...
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Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach
... to citrullinated proteins are expected to be produced in the synovial compartment [13] given that the anti-CCP antibodies constituted a higher pro- portion of immunoglobulin (Ig) G) in synovial fluid (SF) ...
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Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis
... the citrullinated tissue proteins to allow their recognition by an antibody raised against similarly modified citrullinated proteins ...of citrullinated molecules independent of the ...
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