CK2 activity
Association of Elevated Protein Kinase CK2 Activity with Aggressive Behavior of Squamous Cell Carcinoma of the Head and Neck
... CK2 activity was measured in subcellular fractions of 20 SCCHN tumors (0) and in six specimens of normal upper aerodigestive tract mucosa (O): CK2 activity in SCCHN subcellular fractions[r] ...
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CK2-NCoR signaling cascade promotes prostate tumorigenesis
... a CK2-dependent manner. CK2 is known to participate in diverse cell signaling and aberrant expression of CK2 is believed to cause tumor development ...elevated CK2 activity in ...
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5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury
... of CK2 activity, which obstructs I/R-induced dissociation between CK2α and Rac1, decreases NADPH oxidase activtiy, inhibits ROS production and finally realizes the protective effect of ...
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An Investigation of the CK2-dependent Phosphoproteome using Inhibitor Refractory CK2-alpha
... some CK2 substrates increase in response to CX-4945 ...the CK2 inhibitor Quinalizarin ...by CK2 (95), such that their dephosphorylation results in an apparent increase in the phosphopeptide ...
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Phosphorylation of PRH/HHEX by Protein Kinase CK2 Regulates Cell Proliferation and Cell Migration in Diverse Cell Types
... by CK2-dependent phosphorylation resulting in increased cell proliferation and cell migration, the inhibition of CK2 in these tissues would be expected to restore PRH ...growth. CK2 inhibitors have ...
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Protein kinase CK2 in the ER stress response
... kinase CK2 is a serine/threonine protein kinase composed of two catalytic α- or α’-subunits and two non- catalytic ...that CK2 is implicated in the decision of life and death of a cell ...that CK2 ...
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Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
... of CK2 regulation are poorly under- ...for CK2 during pathogeneses associated with inflammation [26]. CK2 regulates the activity of several key transcription factors implicated in ...
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Antitumoral activity of allosteric inhibitors of protein kinase CK2
... of CK2 activity. Indeed, involvement of CK2 in cell cycle regulation is well ...documented. CK2 is required at multiple transitions in the cell cycle (including G0/G1, G1/S and ...
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Mitotic Regulation of Protein Kinase CK2
... that CK2 could be a vital component of SAC signalling, which acts at the metaphase to anaphase transition to ensure that all chromosomes are properly attached to the mitotic spindle before initiation of sister ...
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Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2
... by CK2, also showed significantly decreased phos- phorylation in A549 cells (Figure ...total CK2, total Akt and β-actin were ...and CK2 activity (Figure ...
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The Rational Design and Evaluation of CK2alpha Mutants Bearing Inhibitor-Refractory Amino Acid Substitutions
... of CK2, indicating the requirement of CK2 activity, and not just the presence of the kinase 46 ...kinase CK2 in maintaining viability demonstrated that down regulation of CK2 using ...
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Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery
... of CK2 β along with CK2 α stimulates CK2 activity, which was a further hint on a possible functional subunit inter- action at the ...false-positive activity data in the whole-cell ...
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CK2 Protein Kinase Is Stimulated and Redistributed by Functional Herpes Simplex Virus ICP27 Protein
... of activity similar those stimulated by infection with the ...activated CK2 (representative mutants are shown in Fig. 2B, lanes 8 and 9). CK2 activation coincides with its redistribution from the ...
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Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor
... of CK2, a pleiotropic kinase that regulates numerous functions, may contribute to apoptosis of CLL ...of CK2 may be a fundamental cause for the addiction to CK2 activity displayed by tumor ...
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CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression
... that CK2 promotes the degradation of p53 by phosphorylating and activating ...since CK2 activity is elevated in breast and cervical cancers [15, 16], and inhibition of CK2 is a promising ...
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Role of protein kinase CK2 in antitumor drug resistance
... The CK2/PTEN axis is also implicated in the response to BRAF ...increased CK2/PTEN binding, with consequent PTEN inhibition ...and CK2 inhibitors [89], but, in this case, PTEN was unchanged in cells ...
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The activities of protein kinase CK2 in oogenesis of `Xenopus laevis'
... Histone deacetylase activity is accumulated in Xenopus oocytes as protein complexes and is transported to the nucleus prior to maturation.. LLINAS*, JAMES RYAN*, DARREN A.[r] ...
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MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer
... the CK2-specific site (S129), while partially inhibiting phosphorylation of the canonical PDK-1 and mTORC phospho-acceptor regulatory sites (S308 and ...gene activity in UM-SCC1 ...Thus, CK2 ...
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Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation
... kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and ...falciparum CK2, ...
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Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α’: implications for pathological roles of CK2 in promoting cancer cell survival.
... of CK2 to investigate the relationship between CK2 and caspase pathways [29], we have observed a striking preference of CK2α′ for the phosphorylation of caspase-3 in ...oncogenic activity of CK2α′ in ...
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