CK2 inhibitor
MEK Inhibitor PD-0325901 Overcomes Resistance to CK2 Inhibitor CX-4945 and Exhibits Anti-Tumor Activity in Head and Neck Cancer
... the CK2-specific site (S129), while partially inhibiting phosphorylation of the canonical PDK-1 and mTORC phospho-acceptor regulatory sites (S308 and ...cycle inhibitor p21 with different time course in ...
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Original Article CK2 inhibitor CX4945 enhances the radiation sensitivity of human gastric cancer cells
... Abstract: Chemotherapy and radiotherapy are often combined for treatment of cancers include gastric cancer. However, cancer cells are commonly developed cross-resistance to chemotherapy and radiotherapy and lead to the ...
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Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation
... kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and ...falciparum CK2, ...
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Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2
... that CK2 overexpression is associated with multiple human cancers and may therefore be a promis- ing target for cancer therapy, we decided to screen the natural product library obtained from the NCI to iden- tify ...
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Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery
... of CK2 β along with CK2 α stimulates CK2 activity, which was a further hint on a possible functional subunit inter- action at the ...selective CK2 inhibitor ...
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Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth
... kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell ...regulatory CK2 subunits by immunohistochemistry in 57 ...
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Cutaneous Human Papillomavirus Type 38 E7 Regulates Actin Cytoskeleton Structure for Increasing Cell Proliferation through CK2 and the Eukaryotic Elongation Factor 1A
... the CK2 kinase, which is involved in several cellular functions ...target CK2 to induce the disruption of the actin cytoskel- eton through the MEK-ERK ...of CK2 is significantly increased in cells ...
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CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression
... that CK2 promotes the degradation of p53 by phosphorylating and activating ...since CK2 activity is elevated in breast and cervical cancers [15, 16], and inhibition of CK2 is a promising treatment ...
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Targeting chronic lymphocytic leukemia using CIGB-300, a clinical-stage CK2-specific cell-permeable peptide inhibitor
... kinase CK2 for their viability in ...selective CK2 inhibitor peptide undergoing clinical trials for several ...of CK2 inhibitors in the clinical arsenal against ...
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Role of protein kinase CK2 in antitumor drug resistance
... ent CK2 inhibitor, Quinalizarin, was exploited to reduce viability, proliferation and migration of lung adenocarcin- oma cells with different EGFR genotypes ...other CK2 inhibi- tors were tested; ...
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Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis
... of CK2, were observed to translocate into nuclear in cancer cells with the treatment of ...and CK2 inhibitor was confirmed in tumor xenograft ...that CK2-mediated phosphorylation of ARC ...
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Characterization of the catalytic CK2 subunits with substitutions at residues involved in inhibitor binding
... exhibiting CK2 inhibitor-dependent decreases in phosphorylation [87, ...mutant CK2 kinases with both CX-4945 and inhibitor ...and inhibitor VIII, pIF2β antibody showed a significant ...
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CK2-NCoR signaling cascade promotes prostate tumorigenesis
... Both human PC-3 and LNCaP were from the American type culture collection (ATCC) (Rockville, Maryland, USA) and cultured in RPMI 1640 media (Invitrogen, Carlsbad, CA, USA) supplemented with 10% FBS. The CK2 ...
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Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells
... whether CK2 was involved in the release process, the specific CK2 inhibitor was ...by CK2 inhibition, indicating a possible role of CK2 in cytokine production after IR ...
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CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin
... the CK2 enzyme can be therapeutically exploited in MPNSTs, given CK2’s role in mainta ining oncogenic phenotypes including stabilization of ...the CK2 inhibitor, CX-4945 (Silmitasertib), and ...
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Functional Analysis of Protein Kinase CK2 of the Human Malaria Parasite Plasmodium falciparum
... Within the alveolates, Plasmodium yoelii yoelii (125 residues) and Plasmodium vivax (157 residues) also have long extensions, but the extension of P. falciparum is the longest known. Homo- repeat-containing proteins make ...
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Protein kinase CK2 in the ER stress response
... about CK2 targeting ATF6, neither to the ER nor to the Golgi ...with CK2 whereas the expression of downstream targets of ATF6 is regulated by ...the CK2 inhibitor TBB. The same effect was ...
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An Investigation of the CK2-dependent Phosphoproteome using Inhibitor Refractory CK2-alpha
... some CK2 substrates increase in response to CX-4945 ...the CK2 inhibitor Quinalizarin ...by CK2 (95), such that their dephosphorylation results in an apparent increase in the phosphopeptide ...
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Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
... of CK2 in AD pathology, we compared symptomatic, late-stage AD cases (Braak V + VI) with non-demented and pre-clinical AD cases (Braak 0–II), including cases of ...PART. CK2 levels showed a prominent ...
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The activities of protein kinase CK2 in oogenesis of `Xenopus laevis'
... Histone deacetylase activity is accumulated in Xenopus oocytes as protein complexes and is transported to the nucleus prior to maturation.. LLINAS*, JAMES RYAN*, DARREN A.[r] ...
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