CK2, protein kinase CK2
Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation
... human protein kinase CK2 in the regulation of cell proliferation and apoptosis, together with the fact that this kinase is up-regulated in cancer, has led to efforts to target protein ...
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Protein kinase CK2 in the ER stress response
... Protein kinase CK2 is a serine/threonine protein kinase composed of two catalytic α- or α’-subunits and two non- catalytic ...that CK2 is implicated in the decision of life and ...
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Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives
... that CK2 is involved in the development of neurodegenerative diseases [12]: Alzheimer’s disease [13], Parkinson’s disease [14, 15], schizophrenia [16], Guam-Parkinson’s de- mentia, progressive supranuclear palsy ...
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The Human Adenovirus Type 5 E1B 55-Kilodalton Protein Is Phosphorylated by Protein Kinase CK2
... a protein kinase CK2 phosphor- ylation consensus sequence, suggesting that this kinase is responsible for E1B-55K phosphorylation ...cellular protein kinase ...confers ...
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The Multiple Personalities of the Regulatory Subunit of Protein Kinase CK2: CK2 Dependent and CK2 Independent Roles Reveal a Secret Identity for CK2β
... t Protein kinase CK2 (formerly casein kinase II), an enzyme that participates in a wide variety of cellular processes, has traditionally been classified as a stable tetrameric complex ...
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Hepatitis C Virus NS2 Protein Is Phosphorylated by the Protein Kinase CK2 and Targeted for Degradation to the Proteasome
... (NS2) protein is a hydrophobic transmembrane protein, described to be involved in different functions, such as apoptosis inhibition and gene transcription ...NS2 protein turnover and found that NS2 ...
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Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway
... Protein kinase CK2 (thereafter called CK2) is a pleiotro- pic serine/threonine PK, with over 300 substrates identi- fied in mammalian cells [10] and documented roles in multiple cellular ...
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Antitumoral activity of allosteric inhibitors of protein kinase CK2
... cells, protein kinase CK2 is a relevant physiopathological target for development of chemical ...specific CK2 inhibitors. First, we demonstrated that CK2 inhibition (IC 50 = ...
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Phosphorylation of PRH/HHEX by Protein Kinase CK2 Regulates Cell Proliferation and Cell Migration in Diverse Cell Types
... odomain protein (PRH)/haematopoietically expressed homeobox protein (HHEX) is a tran- scription factor that controls cell proliferation and cell migration in a variety of tissues in the adult and in the ...
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Quantitative Proteomic Characterization of CX-4945, a Clinical Stage Inhibitor of Protein Kinase CK2
... by protein kinases in eukaryotes. Expectedly, deregulation of kinase activity can contribute to aberrant signaling processes implicating kinases in the progression of diseases such as cancer ...on ...
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Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α’: implications for pathological roles of CK2 in promoting cancer cell survival.
... Protein kinase CK2 has emerged as a promising candidate for the treatment of a number of ...regulatory CK2 subunits are generally expressed at similar levels to form tetrameric complexes, ...
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Mitotic Regulation of Protein Kinase CK2
... by protein kinases is a regulatory mechanism crucial for cell signalling, providing a temporary switch in protein function leading to the proper cellular response to a ...mitosis. Protein kinases ...
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Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
... for protein kinase CK2 in the neuroinflammatory response in ...[88]. Protein kinases can be targeted by relatively small compounds that are able to pass the BBB ...of protein ...
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Functional Analysis of Protein Kinase CK2 of the Human Malaria Parasite Plasmodium falciparum
... Within the alveolates, Plasmodium yoelii yoelii (125 residues) and Plasmodium vivax (157 residues) also have long extensions, but the extension of P. falciparum is the longest known. Homo- repeat-containing proteins make ...
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Protein Kinase CK2 Holoenzyme Promotes Start-Specific Transcription in Saccharomyces cerevisiae
... the CK2  subunit is known to be important for stabilizing the catalytic subunits and modulating CK2 specificity toward its sub- strates ...of CK2 in the regulation of cell cycle progression in ...
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Cyclic nucleotide phosphodiesterase 3B is connected to osteopontin and protein kinase CK2 in pancreatic β cells
... taining 300 mg/l L-glutamine and supplemented with 100 units/ml penicillin and 100 µg/ml streptomycin were used for treatment of INS-1 (832/13) cells. Cells were pre-incubated in RPMI 1640 supplemented with 1 mM glucose ...
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Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery
... of CK2 β along with CK2 α stimulates CK2 activity, which was a further hint on a possible functional subunit inter- action at the ...selective CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole ...
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The activities of protein kinase CK2 in oogenesis of `Xenopus laevis'
... Histone deacetylase activity is accumulated in Xenopus oocytes as protein complexes and is transported to the nucleus prior to maturation.. LLINAS*, JAMES RYAN*, DARREN A.[r] ...
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Role of protein kinase CK2 in antitumor drug resistance
... exploit CK2 inhibitors against drug ...of CK2 was demonstrated to overcome the resistance to pacli- taxel in gastric cancer [18]: CX-4945 exhibited synergistic effect, in combination with paclitaxel, in ...
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Coumestrol from the national cancer Institute’s natural product library is a novel inhibitor of protein kinase CK2
... that CK2 overexpression is associated with multiple human cancers and may therefore be a promis- ing target for cancer therapy, we decided to screen the natural product library obtained from the NCI to iden- tify ...
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