CLA-1/SR-BI
Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems
... (7). SR-BI is a 509-amino-acid-long member of the CD36 superfamily of ...The SR-BI identified in rodents is an ortholog of (essentially identical to) human CLA-1 (now also called ...
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Scavenger Receptor Class B Is Required for Hepatitis C Virus Uptake and Cross-Presentation by Human Dendritic Cells
... of SR-BI were raised by genetic immunization of BALB/c mice or Wistar rats with a plasmid expressing the full-length human SR-BI ...The SR-BI plasmid (pcDNA CLA-1) ...
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Targeting a host cell entry factor barricades antiviral resistant HCV variants from on therapy breakthrough in human liver mice
... entry[7]. SR-BI targeting monoclonal antibodies (mAbs) have been shown to possess cross- genotypic anti-HCV activity in human-liver mice[8 9] and to inhibit cell-to-cell transmission in vitro and ...
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Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development
... All mice were housed and maintained in a barrier facility at the Kimmel Cancer Center at Thomas Jefferson University. Mice used in this study were athymic nude mice obtained from Taconic (Hudson, NY, USA). Animal ...
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Expression of the Scavenger Receptor Class B type I (SR BI) family in Drosophila melanogaster
... Fig. 5. Temporal regulation of the SR-BIs in non este- roidogenic tissues. Non-homogeneous expression of crq (A-C) in gastric caeca (GC), arroheads indicate cells whit a higher level of expression, (Pv: ...
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An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI
... with SR-BI is not affected substantially by the dele- tion of the first helix (1-59 amino acid) or of the heli- ces 8-10 (185-243 amino acid) of apoA-I, however the double mutations of apoA-I at ...
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Original Article Relationship between SR-BI genetic polymorphism and coronary heart disease and blood lipid level
... exon 1 and intron 5 on blood lipid level and susceptibility to coronary heart disease (CHD) of Chinese Han popula- tion in ...of SR-BI exon 1 and ApaI digestion genotype of SR-BI ...
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Cholesterol binding, efflux, and a PDZ interacting domain of scavenger receptor–BI mediate HDL initiated signaling
... the SR-BI C-terminus and play a role in SR-BI cell surface expression in hepatocytes and in SR-BI–medi- ated selective lipid uptake (24, 37, ...the SR-BI ...
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Scavenger Receptor Class B Type I and Hepatitis C Virus Infection of Primary Tupaia Hepatocytes
... anti-human SR-BI antibodies clearly demonstrates that SR-BI can mediate binding of the viral envelope to ...that SR-BI is not suf- ficient to mediate the HCV infection of primary ...
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Probucol alleviates atherosclerosis and improves high density lipoprotein function
... and SR-BI can reflect the atheroprotective function of HDL ...and SR-BI in peritoneal macrophages and hepatocytes. Paraoxonase 1 (PON1) and Myeloperoxidase (MPO) are enzymes closely ...
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Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies
... receptor BI (SR-BI), and ...and SR-BI or CD81 coreceptor dependence. JFH-1 G451R is highly sensitive to neutralization by gp-specific antibodies, suggesting increased epitope ...
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Regulations of the key mediators in inflammation and atherosclerosis by Aspirin in human macrophages
... class BI (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) to promote cholesterol efflux in the foam cells at the plaques, and the role of NF- B in the overall inflammation related to the ...
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SR BI protects against endotoxemia in mice through its roles in glucocorticoid production and hepatic clearance
... of SR-BI against atherosclerosis may be related to its antiinflam- matory ...function. SR-BI–null mice and combined SR-BI/LDLR double-knockout mice on high-fat diets show ...
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HDL associated estradiol stimulates endothelial NO synthase and vasodilation in an SR BI–dependent manner
... that SR-BI was also expressed in endothelial cells and localized to plasma membrane caveolae (5, ...and SR-BI also may affect the vascular system independently of their role in decreasing ...
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Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection
... -tupaia SR-BI serum blocked HCVpp infection of PTHs, just like the sera acted on the infectivity of HCVpp in ...and SR-BI on the cell ...
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Hepatoma Cell Density Promotes Claudin-1 and Scavenger Receptor BI Expression and Hepatitis C Virus Internalization
... and SR-BI approximately 17 to 20 min after entry initiation, consistent with the internal- ization rates reported in this study (3, 12, ...and SR-BI overexpression in ...
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Regulation of scavenger receptor, class B, type I, a high density lipoprotein receptor, in liver and steroidogenic tissues of the rat
... of SR-BI protein in the adrenal gland and ovary were accompanied by comparable levels of the corresponding mRNA in these tissues Figure ...rat SR-BI ...rat SR-BI ...a 1% ...
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Hepatic expression of scavenger receptor class B type I (SR BI) is a positive regulator of macrophage reverse cholesterol transport in vivo
... of SR-BI in the liver, while reducing levels of HDL-C in plasma, is known to reduce atherosclerosis in mice ...hepatic SR-BI overexpression may pro- mote RCT, but this concept had never been ...
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A TRAIL-Delivered Lipoprotein-Bioinspired Nanovector Engineering Stem Cell-Based Platform for Inhibition of Lung Metastasis of Melanoma
... a SR-BI-based hydrophobic channel on cell membrane when HDL binds to SR-BI, which promotes the efflux and diffusion of lipid contents from HDL into cytoplasm through concentration gradient ...
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A comparative study of enhancements of critical temperature in Bi-Pb-Sr-Ca-Cu-O superconductors
... state reaction technique at elevated sintering temperatures of 840 and 850 o C. To examine the improvements of structural and superconducting properties of the BPSCCO samples, the X-ray diffraction (XRD), scanning ...
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