Claudin-2
Development of Claudin 2 and Claudin 4 in Embryonic and Hatched Chick Intestine
... Dubnoff metabolic shaking incubator at 37°C at 120 cycles/minute. Duodena from 18 day and 20-day old embryos and from hatched chicks were shaken for 30 minutes to collect the entire villus. The contents of each age group ...
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High expression of Claudin-2 in esophageal carcinoma and precancerous lesions is significantly associated with the bile salt receptors VDR and TGR5
... contrast, Claudin-2 forms gated paracellular channels and allows sodium ions and other small positively charged ions to cross between ad- jacent cells ...[19–22]. Claudin-2 expression may be ...
9
Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis
... Using reporter assays and chromatin immunoprecipitation approaches, it has recently been shown that the EGFR-MEK-ERK1/2 pathway can regulate the transcription of CLDN2 in A549 lung adenocarcinoma cells [28]. In ...
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Original Article Identification of claudin-2, -6, -11 and -14 as prognostic markers in human breast carcinoma
... obstacle that tumor cells must overcome for metastasis [7]. TJs consist of three major types of fundamental membrane proteins: occludin, claudin (CLDN), and junctional adhesion mole- cules (JAM) [8, 9]. Although ...
10
Original Article Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin
... of claudin 1 expression was nuclear immunostaining observed in some ...cases. Claudin 1 nuclear location has previ- ously been reported in melanocytic lesions where its translocation was affected by PKC ...
9
Role of tight junction proteins in gastroesophageal reflux disease
... (e.g. Claudin-2, -3, -4, -7 and −18) in Barrett’s metaplasia and carcinogenesis towards esophageal adenocarcinoma ...other 2 endoscopic entities (ERD, NERD), distinct altera- tions in the expression ...
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RETRACTED ARTICLE: Differences in the expression profiles of claudin proteins in human nasopharyngeal carcinoma compared with non-neoplastic mucosa
... of claudin proteins in various cancer types represents an opportunity to deter- mine the mechanism of different therapeutic responses [25, ...of claudin- 1, − 4 and − 7 in nasopharyngeal carcinoma pa- ...
9
Claudins in lung diseases
... influence claudin synthesis by upregulating tran- scription factors like twist, snail or ZEB1 [38,39] result- ing in downregulation of E-cadherin and ...in claudin expression ...occludin, claudin 1 ...
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Paracellular epithelial sodium transport maximizes energy efficiency in the kidney
... in claudin-2–null mice can be com- pletely compensated under even the most extreme circumstances that could be encountered in vivo (near-zero sodium diet), con- firming that the contribution of paracellular ...
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Original Article The expression patterns of tight junction protein claudin-1, -3, and -4 in human gastric neoplasms and adjacent non-neoplastic tissues
... [20]. Claudin-1 was the first reported claudin protein which described as component of TJs, and so a lot of researches are related to this ...protein. Claudin-1 which is structurally related with ...
7
Regulated expression of claudin 4 decreases paracellular conductance through a selective decrease in sodium permeability
... of claudin-4–overexpressing cell lines, trans- fected MDCK cells were plated in twelve-well dishes on Trans-well ...days; claudin-4 protein levels were always compared with that seen in unin- duced cells of ...
10
Clinicopathologic significance of claudin-6, occludin, and matrix metalloproteinases −2 expression in ovarian carcinoma
... example, claudin-3 and claudin-4 were expressed at high levels in endometrioid adenocarcinoma [19] and prostate cancer [20]; claudin-10 expression was up-regulated in hepatocel- lular carcinoma [21] ...
8
Expression of CLDN1 and CLDN10 in lung adenocarcinoma in situ and invasive lepidic predominant adenocarcinoma
... kinase 2 activations. Claudin-7 was found to be decreased in invasive ductal carcinomas [14], head and neck cancer [15] and metastatic breast cancer ...[16]. Claudin-3 and −4 were frequently elevated ...
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Toll-like receptor 5-mediated IL-17C expression in intestinal epithelial cells enhances epithelial host defense against F4+ ETEC infection
... of claudin-1 and claudin-2 in ETEC infected IPEC-J2 cells were further analyzed by confo- cal ...Both claudin-1 and -2 were increased in ETEC infected IPEC-J2 cells: claudin-1 is ...
14
Effects of a high-sodium diet on renal tubule Ca2+transporter and claudin expression in Wistar-Kyoto rats
... Renal claudin-2 protein decreased, but claudin-7, -8, -16 or -19 mRNA was not altered with chronic salt loading Claudin-2 forms paracellular cation pore in the proximal ...cortical ...
9
The Tight Junction Proteins Claudin-1, -6, and -9 Are Entry Cofactors for Hepatitis C Virus
... against claudin-1 (1:500), 12H12 monoclonal antibody (MAb) against claudin-2 (1:500), and 3E2C1 MAb against claudin-4 (1:500) and Santa Cruz antibodies C20 goat polyclonal antibody against ...
6
Low claudin-6 expression correlates with poor prognosis in patients with non-small cell lung cancer
... staining, 2 points for yellowish brown staining, and 3 points for brown ...as claudin-6 positive; otherwise, the sample was considered negative for claudin-6 ...low claudin-6 expression was ...
7
Original Article Panaxatriol saponins attenuate blood-brain barrier disruption in rats following transient middle cerebral artery occlusion
... of 2 mm thick cor- onal sections. The brain sections were stained with a 2% TTC (Sigma, St Louis, MO, USA) solu- tion at 37°C for 30 min and then fixed in 4% (w/v) paraformaldehyde 24 hours ...
12
Claudin-19 Expression at the Neuromuscular Junction.
... First, claudin-19 expression at neuromuscular junctions was analyzed by observing the overlap expression of AChR and claudin-19 labeling on muscle fiber ...where claudin-19 was expressed at each ...
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Claudin 5: Gatekeeper of neurological function
... of claudin-5 and ZO-1 were observed in the ...of claudin-5 within 12 h of kainic acid injection with increased levels observed after 3 ...days, claudin-5 in the vasculature remained diffuse and ...
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