cleaved caspase-3
Original Article Elevated cleaved caspase-3 is associated with shortened overall survival in several cancer types
... regeneration. Cleaved caspase-3, a key executor in apopto- sis, was involved in the growth stimulation [5-7, ...of caspase-3 either in tumor cells or in tumor stroma resulted in ...
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Original Article Ginsenoside Rg1 suppressed inflammation and neuron apoptosis by activating PPARγ/HO-1 in hippocampus in rat model of cerebral ischemia-reperfusion injury
... bcl-2, cleaved caspase-3, cleaved caspase-9 and RAGE in IR ...bcl-2, cleaved caspase-3 (c-caspase-3), cleaved caspase-9 ...
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Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway
... Bax, cleaved caspase-3, cleaved caspase-9 and the ratio of LC3II/LC3I, markedly increased after RPMI 8226 cells were treated with mTOR/p70s6k signaling pathway–specific inhibitor ...
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Behavioral stress accelerates prostate cancer development in mice
... activated cleaved caspase-3 labeling was used to identify apoptotic ...of cleaved caspase-3–labeled cells in immunostained sections was counted relative to the total number of ...
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ZnO nanoparticle induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
... elicit caspase-3 activation in a dose- and time-dependent ...NP-induced cleaved PARP and cleaved caspase-3 expression, but not ERK inhibitor (U0126) or p38 MAPK inhibitor ...
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Globular adiponectin protects H9c2 cells from palmitate-induced apoptosis via Akt and ERK1/2 signaling pathways
... analyze cleaved caspase-3 and the cleav- age of poly (ADP-ribose) polymerase (PARP), two well- established hallmarks of apoptosis ...of cleaved caspase-3 was detected at 2 h ...
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Apoptosis of the fibrocytes type 1 in the spiral ligament and blood labyrinth barrier disturbance cause hearing impairment in murine cerebral malaria
... The localization in the spiral ligament of the cleaved Caspase 3 positive labelled fibrocytes is identical with the known region of the type 1 fibrocytes in the spiral ligament [21]. This pattern ...
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miR-573 regulates cell proliferation and apoptosis by targeting Bax in nucleus pulposus cells
... membranes. After being blocked with 5% non-fat milk for 2 h at room temperature, these membranes were incubated overnight at 4 °C with primary antibodies. Then the membranes were incubated with the goat anti-rabbit ...
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Reduced beta2-glycoprotein I protects macrophages from ox-LDL-induced foam cell formation and cell apoptosis
... The reaction was terminated by adding 1 mL of cold PBS, which contained 100 μM sodium vanadate. The samples were then placed on ice, washed with ice-cold PBS, and lysed in RIPA lysis buffer for 30 mins. Lysates were ...
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Up-Regulated Lipocalin-2 in Pulmonary Hypertension Involving in Pulmonary Artery SMC Resistance to Apoptosis
... ti-cleaved caspase-3, rabbit anti-SOD1, rabbit an- ti-SOD2, rabbit anti-Bax (from Santa Cruz Biotech- nology, USA), rabbit anti-Bcl-2 (from RayBiotech, GA), mouse anti-GAPDH, goat anti-rabbit IgG, ...
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R-roscovitine Reduces Lung Inflammation Induced by Lipoteichoic Acid and Streptococcus pneumoniae
... of cleaved caspase-3 compared with vehicle after 6 h (Figures 1C, D; P < ...the caspase inhibitor zVAD-fmk reversed the amount of cleaved caspase-3 to near vehicle ...
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YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway
... increased protein levels of cleaved PARP and cleaved caspase-3 (Additional file 1: Fig. S1E, G). Second, YAP knockdown significantly reduced multiple activated pro- teins of mTOR signalling, ...
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Costunolide induces mitochondria mediated apoptosis in human gastric adenocarcinoma BGC 823 cells
... administrated 3 times in ...Bcl-2, cleaved caspase 9, cleaved caspase 3, β-actin is internal reference protein) of gastric tumor was detected by ...
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<p>Knockdown Of CCDC132 Attenuates Gastric Cancer Cells Proliferation And Tumorigenesis By Facilitating DNA Damage Signaling</p>
... of cleaved PARP, cleaved Caspase 3 and l κ B α , while there was no signi fi cant change in p-ERK1/2, p-AKT, p-Smad2, cleaved Caspase-7, p-Chk1, p-l κ B α , p-eIF2 α , p-TAK1, ...
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Exogenous hydrogen sulfide restores cardioprotection of ischemic post-conditioning via inhibition of mPTP opening in the aging cardiomyocytes
... The physiological and pathological roles of hydrogen sulfide (H 2 S) in the regulation of cardiovascular functions have been recognized. H 2 S protects against the hypoxia/reoxygenation (H/R)-induced injury and apoptosis ...
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Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIPs
... MA). Caspase-3 (#9662), caspase-8 (#9746), PARP (#9542), cleaved caspase 3 (#9661S), cleaved cas- pase 8 (#9496), cleaved PARP (#5625), and green fluores- cence ...
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Original Article Silibinin inhibits inflammation and apoptosis in a rat model of temporal lobe epilepsy
... acrylamide gel electrophoresis (SDS-PAGE). The proteins were then transferred to polyvinyli- dene fluoride (PVDF) membranes by electro- phoresis. The membranes were blocked with 5% skim milk at room temperature for 1 ...
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<p>Gross saponin of <em>Tribulus terrestris</em> improves erectile dysfunction in type 2 diabetic rats by repairing the endothelial function of the penile corpus cavernosum</p>
... Methods: The T2DMED model was constructed by high-fat and high-sugar feeding and streptozotocin injection. After 4 weeks of GSTT intervention. Intracavernous pressure (ICP) and mean arterial pressure (MAP) were measured ...
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The potential functions of FAM46C in oral squamous cell carcinoma
... Notes: HSC4 cells transduced with FAM46C shRNAs (siFAM46C) lentivirus or control shRNA (siNC) lentivirus and at same time treated with U0126 or vehicle (DMSO). (A) Cell apoptosis was evaluated by flow cytometry after 48 ...
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Nitric oxide production is associated to increased lipoperoxidation and active caspase 3 in demyelinated brain regions of the taiep rat
... The cleaved caspase-3 immunoreactivity was analyzed by an immunohistochemical ...against cleaved caspasa-3 (1:300 dilution, Cell Signaling Technology, 3 Trask Lane, Danvers, MA ...
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